Signaling pathways and targeted therapies for psoriasis

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 27, 2023

Abstract Psoriasis is a common, chronic, and inflammatory skin disease with high burden on individuals, health systems, society worldwide. With the immunological pathologies pathogenesis of psoriasis becoming gradually revealed, therapeutic approaches for this have gained revolutionary progress. Nevertheless, mechanisms less common forms remain elusive. Furthermore, severe adverse effects recurrence upon treatment cessation should be noted addressed during treatment, which, however, has been rarely explored integration preliminary findings. Therefore, it crucial to comprehensive understanding behind pathogenesis, which might offer new insights research lead more substantive progress in expand clinical options treatment. In review, we looked briefly introduce epidemiology, subtypes, pathophysiology, comorbidities systematically discuss signaling pathways involving extracellular cytokines intracellular transmission, as well cross-talk between them. discussion, also paid attention potential metabolic epigenetic molecular mechanistic cascades related its comorbidities. This review outlined current psoriasis, especially targeted therapies novel strategies, mechanism recurrence.

Language: Английский

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Novel insights into atopic dermatitis

Journal of Allergy and Clinical Immunology, Journal Year: 2022, Volume and Issue: 151(5), P. 1145 - 1154

Published: Nov. 22, 2022

Language: Английский

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Dendritic Cells and Macrophages in the Pathogenesis of Psoriasis

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 28, 2022

Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema. This impairs patients’ quality of life enormously. Pathological findings demonstrate proliferation and abnormal differentiation keratinocytes massive infiltration immune cells. The pathogenesis psoriasis complicated. Among cells, dendritic cells play pivotal role in the development both initiation maintenance phases. In addition, it has been indicated that macrophages contribute to especially phase, although studies on are limited. this article, we review roles psoriasis.

Language: Английский

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Macrophage polarization: an important role in inflammatory diseases

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 10, 2024

Macrophages are crucial cells in the human body's innate immunity and engaged a variety of non-inflammatory reactions. can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages anti-inflammatory M2-type macrophages. During inflammation, activated alternatively, maintaining reasonably steady ratio is critical for homeostasis

Language: Английский

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Advances in the study of macrophage polarization in inflammatory immune skin diseases

Journal of Inflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Oct. 12, 2023

Abstract When exposed to various microenvironmental stimuli, macrophages are highly plastic and primarily polarized into the pro-inflammatory M1-type anti-inflammatory M2-type, both of which perform almost entirely opposing functions. Due this characteristic, different functions at stages immunity inflammation. Inflammatory immune skin diseases usually show an imbalance in M1/M2 macrophage ratio, altering polarization phenotype can either make symptoms worse or better. Therefore, review presents mechanisms polarization, inflammation-related signaling pathways (JAK/STAT, NF-κB, PI3K/Akt), role inflammatory (psoriasis, AD, SLE, BD, etc.) provide new directions for basic clinical research related diseases.

Language: Английский

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Pathogenesis, multi-omics research, and clinical treatment of psoriasis

Journal of Autoimmunity, Journal Year: 2022, Volume and Issue: 133, P. 102916 - 102916

Published: Oct. 6, 2022

Language: Английский

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Unwinding circular RNA’s role in inflammatory pulmonary diseases

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2023, Volume and Issue: 397(5), P. 2567 - 2588

Published: Nov. 2, 2023

Language: Английский

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The macrophage polarization in inflammatory dermatosis and its potential drug candidates

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114469 - 114469

Published: March 2, 2023

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard repair of diseased skin. As a member the human innate immune cells, macrophages usually show different phenotypes in diseases. The macrophage phenotype (M1/M2) imbalance caused increase M1 or decrease M2 common dermatosis. In recent years, with deepening research on skin diseases, more natural medicines/traditional Chinese medicines (TCMs), represented Shikonin Angelica Dahurica, have shown their therapeutic effects affecting polarization macrophages. This review introduced dermatosis, such as psoriasis. Then summarized medicines/TCMs that potential so far mechanisms action proteins/signal pathways involved. We found TCMs listed this are closely related to theory five flavors four properties medicinal, most them bitter, acrid sweet. Bitter antipyretic, anti-inflammatory antibacterial effects, which may improve inflammation infiltration. Acrid effect promoting blood circulation, while sweet nourishing. These 2 accelerate lesions conclusion, we hope provide sufficient knowledge for medicine development imbalance.

Language: Английский

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RNA modification in cardiovascular disease: implications for therapeutic interventions

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Oct. 27, 2023

Abstract Cardiovascular disease (CVD) is the leading cause of death in world, with a high incidence and youth-oriented tendency. RNA modification ubiquitous indispensable cell, maintaining cell homeostasis function by dynamically regulating gene expression. Accumulating evidence has revealed role aberrant expression CVD caused dysregulated modification. In this review, we focus on nine common modifications: N 6 -methyladenosine (m A), 1 5-methylcytosine 5 C), 7 -methylguanosine G), 4 -acetylcytosine (ac pseudouridine (Ψ), uridylation, adenosine-to-inosine (A-to-I) editing, modifications U34 tRNA wobble. We summarize key regulators their effects expression, such as splicing, maturation, transport, stability, translation. Then, based classification CVD, mechanisms which occurs progresses through are discussed. Potential therapeutic strategies, therapy, reviewed these mechanisms. Herein, some (such stroke peripheral vascular disease) not included due to limited availability literature. Finally, prospective applications challenges discussed for purpose facilitating clinical Moreover, look forward more studies exploring roles future, there substantial uncultivated areas be explored.

Language: Английский

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Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles

Theranostics, Journal Year: 2024, Volume and Issue: 14(3), P. 1049 - 1064

Published: Jan. 1, 2024

Macrophage-associated inflammation and keratinocytes excessive proliferation inflammatory cytokines secretion induced by stimulation play an important role in the progression of psoriasiform dermatitis. However, how these two types cells communicate remains obscure.

Language: Английский

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