American Journal of Clinical Dermatology,
Journal Year:
2022,
Volume and Issue:
24(1), P. 135 - 141
Published: Oct. 30, 2022
Problems
in
the
definition
and
classification
of
angioedema,
leading
to
difficulties
its
diagnosis
treatment,
have
been
identified;
therefore,
an
improvement
current
angioedema
is
required.The
aim
this
study
was
propose
a
practical
without
wheals
that
helps
establish
differential
take
appropriate
therapeutic
decisions.An
initial
proposal
agreed
by
scientific
committee
experts
subsequently
validated
panel
means
consensus
based
on
Delphi
methodology.
Forty-five
items
classification,
diagnosis,
treatment
were
proposed
for
survey.Most
(93.8%)
after
two
rounds.
All
panelists
with
as
well
most
clinical
characteristics.
The
established
three
groups:
histamine-mediated,
bradykinin-mediated,
unknown
mechanism
angioedema.
characteristics
types
also
agreed,
except
allergic
histamine-mediated
which
generated
debate.
Regarding
treatments,
although
there
broad
agreement
items,
lack
knowledge
about
some
treatments
pathology
observed.The
accepted
high
degree
agreement;
however,
available
needs
be
increased
improved.
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 11, 2025
Leukocytoclastic
vasculitis
(LCV)
is
an
immune-mediated
small-vessel
with
various
underlying
causes.
We
present
a
unique
case
of
LCV
in
elderly
man
Fitzpatrick
phototype
V
skin
to
highlight
multi-organ
signs
associated
this
rare
pathology.
Our
patient
presented
evolving,
diffusely
spread
rash
following
respiratory
symptoms
accompanied
by
muscle
weakness,
scant
hemoptysis,
and
decreased
visual
acuity.
A
comprehensive
diagnostic
approach,
including
biopsy,
revealed
eosinophilia.
Treatment
through
multidisciplinary
approach
included
systemic
steroids,
topical
ointments,
empiric
antibiotics.
The
showed
gradual
improvement
was
discharged
after
nine
days
hospitalization.
Differential
diagnoses
for
the
infections,
inflammatory
processes,
autoimmune
vasculitides
such
as
immunoglobulin
(IgA)
vasculitis,
urticarial
cryoglobulinemic
anti-neutrophil
cytoplasmic
antibody
(ANCA)-associated
vasculitides.
While
most
instances
are
typically
skin-limited
self-resolving,
highlights
diffuse
involvement
requiring
broad
perspective.
Paciente
femenina
de
43
años,
sin
antecedentes
alergias
conocidas,
consulta
a
medicina
general
por
presentar
habones
acompañados
prurito
intenso
más
6
semanas
evolución.
Journal of Translational Autoimmunity,
Journal Year:
2024,
Volume and Issue:
9, P. 100244 - 100244
Published: June 20, 2024
Lupus
nephritis
(LN)
diagnosis
and
follow-up
requires
noninvasive
biomarkers.
Therefore,
the
added
value
of
coupling
urinary
soluble
(s)CD163/creatinuria
ratio
with
serological
markers
was
evaluated
in
a
real-world
clinical
practice.
To
this
end,
monocentric
retrospective
study
conducted
139
SLE
patients
biopsy-proven
having
an
active
LN
(LN-A,
n
=
63
positive
SLEDAI-renal
score)
or
inactive
(n
76),
as
well
98
non-renal
patients.
The
sCD163/creatinuria
outperformed
for
predicting
LN-A
(AUC>0.972;
p
<
10−4
100
%
specificity
threshold
fixed
at
320
ng/mmol),
monitoring
renal
activity
allowing
prediction
impending
flares
remissions
(AUC
0.789,
10−4).
elevated
spot
proteinuria/creatinuria
(p
8
×
10−6)
10−3)
were
risk
developing
end-stage
kidney
disease
but
cannot
substitute
biopsy
to
discriminate
from
other
glomerulonephritis.
Among
14),
anti-dsDNA
anti-C1q
antibodies
(Abs)
(AUC>0.750
versus
non-LN
patients,
AUC>0.640
LN-IR
patients)
best
predicted
LN-A,
higher
levels
retrieved
class
III/IV
proliferative
LN-A.
In
multivariate
logistic
regression
analysis,
remained
only
statistically
significant
biomarker
predict
0.001).
conclusion,
compared
classical
markers,
provides
additional
parameter
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 3323 - 3331
Published: Nov. 1, 2023
Abstract:
COVID-19
was
a
worldwide
emergency,
leading
to
global
health
crisis,
which
completely
revolutionized
every
aspect
of
human
life.
Several
strategies
were
adopted
limit
the
spreading
infection
such
as
testing
and
contact
tracing,
quarantine
isolation,
use
face
mask,
social
distancing,
lockdowns,
travel
restrictions,
etc.
Of
these,
vaccines
most
important
measures
reduce
transmission
virus
severity
infection,
in
order
overcome
pandemic.
Fortunately,
vaccination
campaign
success,
showing
be
efficient
controlling
preventing
COVID-19,
reducing
risk
disease
progression,
hospitalization,
mortality.
Monitoring
addressing
vaccine-related
adverse
events
have
been
essential
for
maintaining
public
confidence.
Indeed,
with
increasing
number
administered,
various
cutaneous
reactions
reported,
making
dermatologists
key
players
their
recognition
treatment.
Particularly,
several
diseases
findings
reported.
note,
also
viral
reactivations
described
following
vaccination.
Among
varicella
zoster
(VZV)
reactivation
has
collected.
Globally,
an
early
diagnosis
accurate
treatment
herpes
(HZ)
is
mandatory
possible
complications.
In
this
context,
we
conducted
review
current
literature
investigating
cases
HZ
aim
understanding
causal
correlation
underlying
pathogenetic
mechanisms
offer
clinicians
wide
perspective
on
VZV
vaccines.
Keywords:
vaccination,
zoster,
safety
Clinical Case Reports,
Journal Year:
2022,
Volume and Issue:
10(6)
Published: June 1, 2022
Abstract
The
role
of
IL‐5
in
chronic
spontaneous
urticarial
(CSU)
is
unclear.
It
may
be
that
benralizumab
an
important
bidirectional
modifier
CSU;
is,
blocking
improve
CSU
some
patients,
but
it
possible
worsen
others.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 14, 2023
Introduction
Chronic
spontaneous
urticaria
(CSU)
is
mainly
manifested
as
wheals
and
erythema
on
the
skin
accompanied
by
itching,
which
will
cause
emotional
anxiety
seriously
affect
quality
of
life
in
patients.
Palmatine
(PAL)
a
main
chemical
component
Yajieshaba,
has
been
found
to
effectively
alleviate
symptoms
food
allergy.
However,
its
role
mechanism
CSU
remain
unclear.
The
present
study
aimed
investigate
protective
effect
PAL
rats.
Methods
We
replicated
rat
model
intraperitoneal
injection
ovalbumin
(OVA)
rats
days
0,
2,
4,
14,
with
double
dose
given
last
challenge.
PAL,
loratadine
saline
were
gavage
from
day
5
14.
observed
pathologic
changes,
mast
cell
degranulation,
immune
factor
levels,
inflammatory
response
autophagy-related
protein
expression
Results
treatment
be
effective
alleviating
CSU-like
lesions
reducing
itching
degranulation
Compared
OVA
group,
levels
factors
significantly
reduced,
neutrophil
recruitment
was
alleviated,
suggesting
reduced
response.
autophagy
results
showed
that
further
increased
LC3,
Beclin-1
p-LKB1,
p-AMPK,
Atg5,
Atg12
Atg5-Atg12,
while
P62
p-p70S6K1
decreased.
They
collectively
suggested
autophagic
flux
activated
after
treatment.
there
an
increase
LC3I,
probably
due
fact
induced
accumulation
order
provide
substrate
for
generation
more
LC3II.
Discussion
Overall,
had
normal
rats,
improved
