Intervening CCL8-CCR8 Signaling Reduces Cutaneous Inflammation and Itch in Mice

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Transcriptomic profiling of dorsal root ganglia in atopic and healthy dogs: A comparative RNA sequencing study with implications in cutaneous itch research

Veterinary Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Abstract Background Itch is a common clinical sign in skin disorders. While the neural pathways of itch transmission from to brain are well understood rodents, same dogs remain unclear. The knowledge gap hinders development effective treatments for canine itch‐related Hypothesis/Objectives This study aimed investigate differential gene expression dorsal root ganglia (DRGs) between healthy and atopic identify specific molecules potentially involved signalling neuroinflammation dermatitis (cAD). Animals Two four dogs. Materials Methods DRGs were collected compare their transcriptional profiles using RNA sequencing. Results Principal component heatmap analyses revealed two distinct clusters separating Consistent with this observation, we identified 627 (543 upregulated 84 downregulated) differentially expressed genes (DEGs) compared We further narrowed down our interest DEGs each dog, which 159 (132 27 DEGs. Among these genes, when focused on signalling–associated molecules, P2RY12 , IL‐2RG TLR1 POSTN significantly upregulated, while MRGPRD LPAR3 both downregulated those Pathway analysis showed significant upregulation CREB neurons, myelination Conclusions Clinical Relevance Our suggested that dysregulation neuroinflammatory might play role pathomechanism cAD as humans.

Language: Английский

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Evaluation of oclacitinib maleate and prednisolone combined therapy for the control of atopic dermatitis in dogs: A controlled clinical trial

Veterinary Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Background Canine atopic dermatitis (cAD) is a chronic inflammatory and pruritic dermatopathy requiring multimodal therapeutic approach. Objective To assess the effectiveness, safety cost of oclacitinib prednisolone treatment in dogs with AD. Animals Twenty‐three client‐owned cAD. Materials Methods Dogs were randomly assigned to one two groups: Group 1 received (0.5 mg/kg every 24 h) for 7 days, then mg/kg) mg/kg), administered alternately day pause between each drug, additional weeks. 2 12 h 14 8 Assessments included Atopic Dermatitis Extent Severity Index, 4th iteration (CADESI‐04) pruritus Visual Analog Scale (PVAS) on Day (D)0, D7, D14, D30, D45 D60. Results Both groups showed significant CADESI PVAS reductions D7 ( p < 0.001). From D14 D60, mean scores remained stable compared no differences groups. Adverse events polyuria polydipsia, three polyphagia 1, all which resolved by D14. In 2, dog experienced polyphagia, had self‐limiting vomiting. Three mild increases liver enzyme concentrations. Conclusions Clinical Relevance The combined protocol was effective safe managing itch inflammation over 60 period. It 73.3% lower alone.

Language: Английский

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Filaggrinopathies—FLG/FLG2: Diagnostic Complexities and Immunotherapy

Journal of Investigative Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A topical Chinese herbal inhibits pruritus and skin inflammation via neural TRPM8 in atopic dermatitis

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156524 - 156524

Published: Feb. 16, 2025

Language: Английский

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