Inborn errors of immunity present with neuropsychiatric symptoms overlapping with autistic behavioral symptoms DOI Open Access

Harumi Jyonouchi

Journal of Translational Genetics and Genomics, Journal Year: 2023, Volume and Issue: 7(4), P. 274 - 90

Published: Dec. 22, 2023

Autism spectrum disorder (ASD) is a behaviorally defined syndrome affected by multiple genetic and environmental factors. A wide variety of risk factors for ASD have been identified many these affect immune functions. This may not be surprising, since the system nervous share common signaling mechanisms each other as part neuroimmune network. The ever-expanding scope inborn errors immunity (IEIs) has revealed pathogenic gene variants that manifest overlapping clinical features neuropsychiatric diseases, including ASD. These IEIs often cause dysregulated activation resultant chronic inflammation affecting organs. Some also changes in morphogenesis plasticity central system. Such patients present with puzzling array some them diagnosed or conditions. progress our understanding disease at molecular levels led to gene-specific treatment measures diseases. In addition, are found laboratory findings neuroinflammation resemble those seen IEI patients. pave way applying specific used such review focuses on describing Emphasis can treated targeting mechanisms. information helpful clinicians who considering genetic/metabolic workup

Language: Английский

Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages DOI Creative Commons
Juan Felipe Valdés‐López, Lady Johana Hernández-Sarmiento, Y. S. Tamayo-Molina

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: April 24, 2024

Interferons (IFNs) are a family of cytokines that activate the JAK-STAT signaling pathway to induce an antiviral state in cells. Interleukin 27 (IL-27) is member IL-6 and/or IL-12 elicits both pro- and anti-inflammatory responses. Recent studies have reported IL-27 also induces robust response against diverse viruses,

Language: Английский

Citations

7
Exploring Advances in Natural Plant Molecules for Allergic Rhinitis Immunomodulation in Vivo and in Vitro DOI Creative Commons

Bingquan Li,

Boyang Dong,

Liangzhen Xie

et al.

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 529 - 565

Published: Feb. 1, 2025

Abstract: Allergic rhinitis (AR) is a prevalent allergic disease that imposes significant economic burdens and life pressures on individuals, families, society, particularly in the context of accelerating globalization increasing pathogenic factors. Current clinical therapies for AR include antihistamines, glucocorticoids administered via various routes, leukotriene receptor antagonists, immunotherapy, several decongestants. These treatments have demonstrated efficacy alleviating symptoms pathological states. However, with growing awareness rising expectations improvements quality life, these become associated higher incidence side effects an elevated risk drug resistance. Furthermore, development intricately dysregulation immune system, yet underlying pathogenetic mechanisms remain incompletely understood. In contrast, widely available natural plant molecules offer multiple targeting pathways uniquely modify typical pathophysiology through immunomodulatory processes. This review presents comprehensive analysis both vivo vitro studies modulate immunity treating AR. Additionally, we examine their specific action animal models to provide new insights developing safe effective targeted while guiding experimental applications against Keywords: molecules, rhinitis, immunomodulation, therapeutic mechanism, research progress

Language: Английский

Citations

0
The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination DOI Creative Commons
Henrike Maatz, Eric L. Lindberg, Eleonora Adami

et al.

Nature Cardiovascular Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Myocarditis, characterized by inflammatory cell infiltration, can have multiple etiologies, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or, rarely, mRNA-based disease 2019 (COVID-19) vaccination. The underlying cellular and molecular mechanisms remain poorly understood. In this study, we performed single-nucleus RNA sequencing on left ventricular endomyocardial biopsies from patients with myocarditis unrelated to COVID-19 (Non-COVID-19), after SARS-CoV-2 (Post-COVID-19) vaccination (Post-Vaccination). We identified distinct cytokine expression patterns, interferon-γ playing a key role in Post-COVID-19, upregulated IL16 IL18 serving as hallmark of Post-Vaccination myocarditis. Although myeloid responses were similar across all groups, the group showed higher proportion CD4 + T cells, Post-COVID-19 exhibited an expansion cytotoxic CD8 natural killer cells. Endothelial cells gene changes indicative vascular barrier dysfunction ongoing angiogenesis groups. These findings highlight shared driving without history or

Language: Английский

Citations

0
The role of type I interferon signaling in myeloid anti-tumor immunity DOI Creative Commons

Sofie Patrizia Meyer,

Rebekka Bauer, Bernhard Brüne

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Tumors often arise in chronically inflamed, and thus immunologically highly active niches. While immune cells are able to recognize remove transformed cells, tumors eventually escape the control of system by shaping their immediate microenvironment. In this context, macrophages major importance, as they initially exert anti-tumor functions before adopt a tumor-associated phenotype that instead inhibits responses even allows for sustaining smoldering inflammatory, growth promoting tumor microenvironment (TME). Type I interferons (IFNs) well established modulators inflammatory reactions. have been shown directly inhibit growth, there is accumulating evidence also play an important role altering cell within TME. present review, we focus on impact type IFNs responses, driven monocytes macrophages. Specifically, will provide overview tumor-intrinsic factors, which impinge IFN-stimulated gene (ISG) expression, like presence nucleic acids, metabolites, or hypoxia. We further summarize current understanding consequences altered IFN macrophage phenotypes, i.e., differentiation, polarization, functions. For latter, macrophage-mediated killing phagocytosis, how affect environment secreting cytokines interacting with cells. Finally, discuss might should be considered future therapies.

Language: Английский

Citations

0
Artemether Ameliorates Dss-Induced Ulcerative Colitis by Modulating Macrophage Polarization DOI
Xinxin Ren, Yi Li, Jia Xu

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus DOI Creative Commons
Shunfen Zhang, Ruqing Zhong,

Miao Zhou

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Baicalin has been widely used for its anti‐inflammatory pharmacological properties, yet effects on bacterial intestinal inflammation and the mechanisms remain unclear. This study revealed that baicalin alleviates through regulating macrophage polarization increasing Lactobacillus amylovorus abundance in colon. Specifically, transcriptomic analysis showed restored Escherichia coli ‐induced genes expression changes including T helper cell 17 differentiation‐related genes, related TLR/IRF/STAT signaling pathway. Subsequent microbial non‐targeted metabolomic these may be to enhancement of upregulation metabolites chrysin, lactic acid, indoles. Furthermore, whole‐genome sequencing provided insights into functional potential metabolic annotations. supplementation mice similarly inhibited M1 TLR4/IRF/STAT Additionally, baicalin, , or chrysin alone could regulate polarization, highlighting their independent potential. Notably, this pathway synthesis chrysin. These findings provide new therapeutic preventing treating inflammation, offering key targets future interventions.

Language: Английский

Citations

0
Macrophage polarization regulates the pathogenesis and progression of autoimmune diseases DOI
Siwen Wu, Songyan Zhao,

Lei Hai

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: 24(7), P. 103820 - 103820

Published: April 21, 2025

Language: Английский

Citations

0
Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling DOI
Stephen T. Yeung, Payal Damani‐Yokota, Sara A. Thannickal

et al.

Immunity, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
ICI-induced cardiovascular toxicity: mechanisms and immune reprogramming therapeutic strategies DOI Creative Commons

Jixuan Zheng,

Yongxiang Yi,

Tengzhen Tian

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

The advent of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, offering life-saving benefits to tumor patients. However, the utilize ICI agents is often accompanied by immune-related adverse events (irAEs), among which cardiovascular toxicities have attracted more and attention. induced predominantly present as acute myocarditis chronic atherosclerosis, both are driven excessive activation. Reprogramming T cells macrophages been demonstrated a pivotal factor in pathogenesis these complications. Therapeutic strategies targeting glycolysis, fatty acid oxidation, reactive oxygen species (ROS) production some other key signaling shown promise mitigating hyperactivation inflammation. In this review, we explored intricate mechanisms underlying ICI-induced highlighted protective potential reprogramming. We emphasize roles cell macrophage reprogramming heart vasculature, showcasing their contributions short-term long-term regulation health. Ultimately, deeper understanding processes will not only enhance safety ICIs but also pave way for innovative manage cancers therapy.

Language: Английский

Citations

0
IRF7 Exacerbates Candida albicans Infection by Compromising CD209-Mediated Phagocytosis and Autophagy-Mediated Killing in Macrophages DOI

Furong Qing,

Lina Sui,

Wenji He

et al.

The Journal of Immunology, Journal Year: 2024, Volume and Issue: 212(12), P. 1932 - 1944

Published: May 6, 2024

Abstract IFN regulatory factor 7 (IRF7) exerts anti-infective effects by promoting the production of IFNs in various bacterial and viral infections, but its role highly morbid fatal Candida albicans infections is unknown. We unexpectedly found that Irf7 gene expression levels were significantly upregulated tissues or cells after C. infection humans mice IRF7 actually exacerbates independent classical function inducing production. Compared to controls, Irf7−/− showed stronger phagocytosis fungus, upregulation C-type lectin receptor CD209 expression, enhanced P53–AMPK–mTOR–mediated autophagic signaling macrophages infection. The administration CD209-neutralizing Ab hindered mouse macrophages, whereas inhibition p53 autophagy impaired killing these macrophages. Thus, compromising capacity via regulating p53–AMPK–mTOR–mediated autophagy, respectively. This finding reveals a novel canonical unexpected enhancing fungal thus providing more specific effective targets for antifungal therapy.

Language: Английский

Citations

3