Unique effect of aspirin on local 15‐oxo‐eicosatetraenoic acid synthesis in asthma patients with aspirin hypersensitivity DOI Creative Commons
Piotr Szatkowski, Anna Gielicz,

Adam Stępień

et al.

Clinical and Translational Allergy, Journal Year: 2024, Volume and Issue: 14(12)

Published: Dec. 1, 2024

Language: Английский

Techniques and analytic workflow for spatial transcriptomics and its application to allergy and inflammation DOI
Haihan Zhang, Matthew T. Patrick, Jingyu Zhao

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2025, Volume and Issue: 155(3), P. 678 - 687

Published: Jan. 19, 2025

Language: Английский

Citations

0
The role of yes‐associated protein in nasal inflammatory diseases DOI Creative Commons
Bing Zhong, Yu Zhao

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Abstract Yes‐associated protein (YAP), a pivotal of the Hippo signaling pathway, plays crucial role in regulating cell proliferation and differentiation. Emerging evidence highlights its significance respiratory inflammatory disorders, including chronic rhinosinusitis, allergic rhinitis. This review delves into impact YAP on individuals affected by these ailments, with specific focus it nasal mucosal epithelial cells. We further explore interplay between mediators, outlining pathological mechanisms through which contributes to tissue restructuring contexts. Despite advancements, gaps persist understanding YAP's broader clinical applications. Future research directions are proposed this article bridge knowledge gaps.

Language: Английский

Citations

0
Multi-omics integration and machine learning identify and validate neutrophil extracellular trap-associated gene signatures in chronic rhinosinusitis with nasal polyps DOI
Fu Shu, Yaping Wang, Linglong Li

et al.

Clinical Immunology, Journal Year: 2025, Volume and Issue: 275, P. 110473 - 110473

Published: March 13, 2025

Language: Английский

Citations

0
Role of ZEB1 in immune response, inflammation and membrane remodeling during neoplasia DOI Creative Commons
Alicia Maria Reveles-Espinoza, Richard Roque, Alba Adriana Vallejo‐Cardona

et al.

Exploration of Immunology, Journal Year: 2025, Volume and Issue: 5

Published: March 20, 2025

Immune response, inflammation, and lipid metabolism have important effects on cancer development progression. Several proteins in tumoral cells and/or tumor microenvironment are involved any of these processes, whereas some them participate all three, such as the zinc finger E-box-binding homeobox 1 (ZEB1) protein. This protein has been proposed to an role invasion metastasis cells, well be malignant transformation resistance treatments. So, this study, we present participation ZEB1 immune, inflammatory, membrane remodeling (lipid metabolism) its interaction with that them. Due importance progression, it may a potential biomarker prognosis target for new therapies.

Language: Английский

Citations

0
Stromal Fibrin Shapes Immune Infiltration Landscape of Pancreatic Ductal Adenocarcinoma DOI
Mazharul Karim, Md. Mahedi Hasan, Seung Hyun Kim

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123280 - 123280

Published: March 1, 2025

Language: Английский

Citations

0
The role of macrophages in chronic rhinosinusitis with nasal polyps DOI Creative Commons
Yuling Zhang, Xinyi Li, Yan Li

et al.

Eye & ENT Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by dysbiosis of microbiota and dysregulation the immune system. Macrophages are essential for protecting against infections, but their roles mechanisms in CRSwNP not fully understood. To date, we gradually recognize heterogeneity macrophages, new subsets macrophages have been identified at transcriptional level due to development single cell RNA‐sequencing. In this review, summarize generation, polarization, phenotype identification, function CRSwNP, providing a comprehensive understanding CRSwNP. Additionally, also explore how interact other cells, including epithelial neurons, which can worsen inflammation. A better role could improve ability clear bacteria reduce chronic inflammation might be clinically beneficial patients.

Language: Английский

Citations

0
The characterization and validation of regulated cell death-related genes in chronic rhinosinusitis with nasal polyps DOI
Hongxia Li, Fei Jing, Wei Xu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 154, P. 114509 - 114509

Published: March 31, 2025

Language: Английский

Citations

0
Exploring the comorbidity association and biological mechanisms of chronic rhinosinusitis and chronic obstructive pulmonary disease DOI Creative Commons
Shihan Liu, Jin Yang,

Yiyi Lin

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Language: Английский

Citations

0
Identification of circulating metabolites associated with chronic rhinosinusitis using Mendelian randomization analysis DOI

Fan Jiang,

Junhao Tu, Wenqi Luo

et al.

Brazilian Journal of Otorhinolaryngology, Journal Year: 2025, Volume and Issue: 91(4), P. 101626 - 101626

Published: April 25, 2025

Language: Английский

Citations

0
The IL‐4–IL‐4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell DOI Creative Commons
Yannis Hara, Mithilesh Kumar Jha, Jeremy Huang

et al.

Allergy, Journal Year: 2024, Volume and Issue: 80(2), P. 440 - 461

Published: Oct. 17, 2024

IL-4 and IL-13 have non-redundant effects in olfaction, with loss of smell mice evoked only by intranasal administration IL-4, but not IL-13. IL-4-evoked pathophysiological on olfaction is independent compromised structural integrity the olfactory neuroepithelium. IL-4-IL-4Rα signaling modulates neuronal crosstalk immune cells, suggesting a functional link between impairment neuroinflammation. Abbreviations: IL, interleukin; KO, knock-out; wk, week; WT, wild-type.

Language: Английский

Citations

3