The roles of bitter and sweet taste receptors in food allergy: Where are we now? DOI Creative Commons
Mo Xian, Anish Maskey,

Daniel Kopulos

et al.

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Food allergy (FA) is a growing global concern, which contributes significantly to anaphylaxis and severe allergic reactions. Despite advancements in treatments like allergen immunotherapy biologics, current approaches have notable limitations there pressing need for new therapeutic strategies. Recent research into taste receptors has unveiled their potential role FA, offering fresh perspectives understanding managing this condition. Taste receptors, particularly type 1 (TAS1Rs/T1Rs, sweet receptors) 2 (TAS2Rs/T2Rs, bitter receptors), are distributed not only the oral cavity but also various extra-oral tissues, interactions with immune responses increasingly recognized. This review highlights connections between exploring how receptor mechanisms might contribute FA pathogenesis treatment. especially TAS2Rs, include multiple subtypes varying ligand specificities, been implicated modulating could serve as targets novel therapies. Additionally, compounds such agents sweeteners that interact show promise influencing outcomes. emphasizes further of involvement suggests targeting these provide avenues intervention future.

Language: Английский

The roles of bitter and sweet taste receptors in food allergy: Where are we now? DOI Creative Commons
Mo Xian, Anish Maskey,

Daniel Kopulos

et al.

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Food allergy (FA) is a growing global concern, which contributes significantly to anaphylaxis and severe allergic reactions. Despite advancements in treatments like allergen immunotherapy biologics, current approaches have notable limitations there pressing need for new therapeutic strategies. Recent research into taste receptors has unveiled their potential role FA, offering fresh perspectives understanding managing this condition. Taste receptors, particularly type 1 (TAS1Rs/T1Rs, sweet receptors) 2 (TAS2Rs/T2Rs, bitter receptors), are distributed not only the oral cavity but also various extra-oral tissues, interactions with immune responses increasingly recognized. This review highlights connections between exploring how receptor mechanisms might contribute FA pathogenesis treatment. especially TAS2Rs, include multiple subtypes varying ligand specificities, been implicated modulating could serve as targets novel therapies. Additionally, compounds such agents sweeteners that interact show promise influencing outcomes. emphasizes further of involvement suggests targeting these provide avenues intervention future.

Language: Английский

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