Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: unknown
Published: Dec. 8, 2023
Language: Английский
Journal of Child Psychology and Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: March 23, 2025
Background Exposure to psychosocial stress is one of the strongest risk factors for major depressive disorder (MDD) in youth, but underlying neurobiological mechanisms are poorly understood. Previous studies on neuroendocrine response youth with MDD scarce, limited cortisol, and rarely considered sex differences. Due puberty‐associated transitions increasing onset adolescence, this study aimed investigate sex‐specific responses hormones as well neuropeptides. Methods In 103 pubertal youths 72 healthy controls (HCs; 62% females, 12–18 years), psychological salivary testosterone, oxytocin reactivity a standardized test (Trier Social Stress Test, TSST) were assessed. Effects group sex, their interactions analyzed using hierarchical linear models, while controlling potentially confounding (such age status). Results Females males showed stronger than HCs. contrast, both female male blunted compared addition, baseline testosterone was elevated Conclusions indicate discrepant MDD, increased psychological, decreased stress. Blunted found across different systems females MDD. These novel findings point fundamentally changed irrespective which may influence successful regulation affected adolescents.
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: March 28, 2025
This study aimed to investigate the association between depressive symptoms and incidence of thyroid nodules (TNs) in Chinese adults, explore whether development, persistence, or recovery from influences risk developing TNs. A total 1,537 adults who underwent medical check-ups, including blood tests, Zung Self-Rating Depression Scales (SDS), ultrasound examinations, were included. The TN prevalence was evaluated, 818 participants free TNs at baseline followed over time. rates analyzed across different mental health statuses: depression-free, depression-developed, depression-recovered, depression-persistent. 31.95%, significantly higher women than men (42.60% vs. 25.82%). also (38.68% 21.52%). Among women, with had shorter height, levels fasting plasma glucose (FPG), triglycerides (TG), glutamyl transpeptidase (GGT), lower high-density lipoprotein cholesterol (HDL-C), a (46.44% 32.92%, p < 0.01) compared those without symptoms. Although FPG non-depressive both groups remained within clinically normal range. These differences not observed men. Over mean follow-up 2.75 years depression-persistent group (16.48/100 person-years) depression-free (6.43/100 person-years; age-adjusted HR: 2.679, 95% CI: 1.513–4.742, = 0.001). Women persistent TNs, suggesting that status may influence development women.
Language: Английский
Citations
0
Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(11)
Published: July 24, 2024
Abstract Mood variability, the day‐to‐day fluctuation in mood, differs between individuals and develops during adolescence. Because adolescents show higher mood variability average than children adults, puberty might be a potential biological mechanism underlying this increase. The goal of preregistered developmental study was to examine neural hormonal underpinnings adolescent‐specific within‐person changes with specific focus on testosterone, cortisol, pubertal status, resting‐state functional brain connectivity. Data from two longitudinal cohorts were used: L‐CID twin (aged 7–13, N at first timepoint = 258) accelerated Leiden Self‐Concept (SC; aged 11–21, 138). In both studies magnetic resonance imaging (rs‐fMRI) data collected, as well daily mood. Additionally, SC self‐reported testosterone cortisol collected. Random intercept cross‐lagged panel models (RI‐CLPM) used relations these measures peaked adolescence levels also showed an Connectivity prefrontal cortex (dlPFC vmPFC) subcortical regions (caudate, amygdala) decreased across development. Moreover, predicted negative next time point, but not vice versa. Further, stronger vmPFC–amygdala connectivity decreases variability. Here, we that development is important adolescents. Practitioner Points peaks Within‐person predict
Language: Английский
Citations
3
International Journal of Hygiene and Environmental Health, Journal Year: 2024, Volume and Issue: 259, P. 114386 - 114386
Published: May 3, 2024
Language: Английский
Citations
2
Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 139, P. 104725 - 104725
Published: June 9, 2022
Language: Английский
Citations
12
Journal of International Medical Research, Journal Year: 2023, Volume and Issue: 51(12)
Published: Dec. 1, 2023
The aetiology of oral mucosal diseases, such as recurrent aphthous ulcer (RAU), lichen planus (OLP) and burning mouth syndrome (BMS), involves many factors, it remains difficult for clinicians to effectively relieve disease symptoms formulate coping strategies. With the rapid development psychology, role mental psychological factors in RAU, OLP BMS has gradually attracted researchers attention, but specific mechanism not been completely determined. This narrative review describes potential neurobiological diseases detailed after introducing relevant research into diseases. Future strategies innovations needed understand treat well how prevent by regulation neuroendocrine system, are also discussed.
Language: Английский
Citations
5
International Clinical Psychopharmacology, Journal Year: 2024, Volume and Issue: unknown
Published: April 18, 2024
To investigate the response to antidepressants while controlling for sex, which has been controversial, 92 outpatient males and females with major depressive disorder were assigned sertraline (100 mg/day) or citalopram (40 in two strata assessed using Hamilton depression rating scale (HDRS) scores brain-derived neurotrophic factor (BDNF), interleukin (IL)-6 cortisol serum levels this 8-week, randomized, parallel-group, double-blind clinical trial. Data of 40 recipients equal representation each medication analyzed, their baseline characteristics not statistically different ( P > 0.05). There no significant differences between outcome changes 0.05), all indicated improvement, but a time-treatment-sex interaction effect BDNF was observed = 0.035). Regarding this, subgroup analyses illustrated significantly greater increase male following treatment 0.020) moderate large size (Cohen’s d 0.76 ). Significant associations percentage IL-6 0.033) HDRS < 0.001). Sex an modifier alterations administration. Further large-scale, high-quality, long-term studies are recommended.
Language: Английский
Citations
1
The World Journal of Men s Health, Journal Year: 2024, Volume and Issue: 42
Published: Jan. 1, 2024
Testosterone extends its impact beyond sexual function, playing a crucial role in shaping overall male health, including aspects such as muscle mass, bone density, mood regulation, and energy levels. Lipoic acid, cofactor for specific enzymes, particularly dehydrogenases involved cellular production, has been studied on testosterone. This comprehensive review systematically scoured PubMed Scopus databases using the keywords "lipoic acid" "testosterone." It encompassed all relevant English papers published from November 1971 to present, full texts abstracts, along with research elucidating biochemical mechanisms linking lipoic acid In summary, consistently restores testosterone levels, offering promise an intervention testicular especially cases of toxicity caused by various harmful agents. Its encompass nitric oxide enhancement, fortification antioxidants, elevation luteinizing hormone, enhancement steroidogenesis, maintenance production. These underscore therapeutic potential health.
Language: Английский
Citations
1
Personalized Medicine in Psychiatry, Journal Year: 2024, Volume and Issue: 45-46, P. 100129 - 100129
Published: June 4, 2024
Language: Английский
Citations
1
Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)
Published: July 2, 2024
Background Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders in women reproductive age. It frequently comorbid with obesity negative emotions. Currently, there are few reports on relationship between emotions patients PCOS. Here we performed both basic clinical studies to study
Language: Английский
Citations
1