Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study: Perceptions des patients sur les thérapies basées sur le microbiome pour les troubles de l’humeur : une étude à méthodes mixtes DOI Creative Commons
Dina Moinul,

Chenhui Hao,

Gina Dimitropoulos

et al.

The Canadian Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 69(7), P. 503 - 512

Published: Feb. 28, 2024

Objective Medications are critical for treating major depressive disorder (MDD) and bipolar (BD). Unfortunately, 30% to 40% of individuals do not respond well current pharmacotherapy. Given the compelling growing body research on gut-brain axis, this study aims assess patient perspectives regarding microbiome-based therapies (MBT) such as probiotics, prebiotics, dietary changes, or fecal microbiota transplantation (FMT) in management MDD BD. Methods This single-centred observational used quantitative qualitative assessments examine perceptions MBT. Participants diagnosed with BD completed an anonymous questionnaire obtaining demographics, prior medication history, symptom burden. Self-assessment questionnaires specific each diagnosis were also used: Quick Inventory Depressive Symptomatology Self-Report (QIDS-SR), Altman Self-Rating Mania Scale (ASRM), General Anxiety Disorder Questionnaire (GAD-7). A logistic regression model analysed association MBT acceptance type, QIDS-SR, GAD-7 scores. bootstrap method assessed proportion acceptance. The assessment consisted 30-minute interviews elicit attitudes towards Results achieved information power n = 20. from 63-item ( 43) showed probiotics (37.2%) top choice, followed by FMT (32.6%), change (25.6%), prebiotics (4.6%). majority participants (72.1%) expressed willingness try their mood disorder, however, analysis did identify statistically significant predictors among GAD-7. Conclusion There is increased focus gut microbiota's role disorders’ etiology treatment. Promising interest underscore necessity exploring educating factors influencing

Language: Английский

Mapping the Scientific Research on Nutrition and Mental Health: A Bibliometric Analysis DOI Open Access
Ramona Hiltensperger,

Jennifer Neher,

Lea Böhm

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 399 - 399

Published: Jan. 22, 2025

Background/Objectives: The connection between nutrition and mental health has become a point of growing interest. In response, nutritional psychiatry research emerged as field dedicated to understanding these interactions. A bibliometric analysis was conducted map the growth trends in this area, providing insights into its evolving scope key contributions. Methods: literature search within Web Science Core Collection. Data performed using result citation report options well visualization software VOSviewer (Version 1.6.20). Results: total 31,556 articles on were published from 2000 2024 across various WoS categories, mainly “Psychiatry”, “Public, Environmental & Occupational Health”, “Nutrition Dietetics”. most prolific groups are based North America. Recent publications cover seven clusters: (1) public social factors, (2) interventions biological mechanisms, (3) elderly, (4) nutrition-related illnesses, (5) lifestyle behavior, (6) observational studies, (7) pregnancy postpartum period. Conclusions: view increasing activities allocation resources research, it is important define priorities close collaboration with service users stakeholders. Research should be approached holistic manner through multidisciplinary consortia ensure comprehensive impactful outcomes.

Language: Английский

Citations

0
Effects of 12-Week Anti-Inflammatory Dietary Education on Depressive Symptoms Among Depressed Patients with Breast Cancer Undergoing Adjuvant Chemotherapy: A Randomized Controlled Trial DOI Open Access
Lan Cheng, Yue Chen, Jianyun He

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 957 - 957

Published: March 9, 2025

Background: Depressive symptoms (DepS) are prevalent among patients with breast cancer. Offering an anti-inflammatory diet is a promising strategy for DepS management, but it costly and difficult to scale up. Instead, dietary education cost-effective may be more conducive the promotion of strategy. Methods: A prospective, assessor-blinded, two-arm randomized controlled trial was designed determine effects 12-week on in cancer depression. Adult female depression receiving adjuvant chemotherapy were recruited. Participants intervention group received education, while control routine nursing care. Outcomes included Center Epidemiologic Studies Depression Scale (CES-D) score, energy-adjusted inflammatory index (E-DII), plasma biomarkers, quality life (QoL), which all assessed at baseline after follow-up. The robustness estimates investigated through sensitivity analyses. post hoc power analysis conducted establish observed effect sizes primary outcomes. Results: total 88.6% (62/70) participants completed entire No statistically significant between-group differences found characteristics, including sociodemographic factors, disease-related lifestyle factors. After intervention, both CES-D score (p = 0.040) E-DII < 0.001) significantly lower than group, QoL increased 0.001). Compared baseline, tumor necrosis factor-α (TNF-α) 0.002) C-reactive protein (CRP) 0.045) levels not group. Conclusions: Anti-inflammatory improve undergoing by regulating inflammation. Given its acceptability practicality, this incorporated into

Language: Английский

Citations

0
Associations of cMIND Diet with depressive and anxiety symptoms among old people in China: a nationwide study DOI

Tengfei Niu,

Yu Zhang, Xilin Zhou

et al.

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(3)

Published: March 12, 2025

Language: Английский

Citations

0
Adherence to the Mediterranean Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and trajectories of depressive symptomatology in youth DOI Creative Commons
Yiwei Pu, Hangyu Tan,

Runqi Huang

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
The effect of fish oil versus krill oil intervention on clinical symptoms and cardiometabolic risk factors in patients with major depressive disorder: A randomized placebo-controlled double-blind trial DOI
Murat Açık, Funda Pınar Çakiroğlu, Atilla Tekın

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Gut Microbiota: A New Challenge in Mood Disorder Research DOI Creative Commons
Giuseppe Marano, Sara Rossi, Greta Sfratta

et al.

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 593 - 593

Published: April 3, 2025

The gut microbiome has emerged as a novel and intriguing focus in mood disorder research. Emerging evidence demonstrates the significant role of influencing mental health, suggesting bidirectional communication between brain. This review examines latest findings on gut–microbiota–brain axis elucidates how alterations microbiota composition can influence this axis, leading to changes brain function behavior. Although dietary interventions, prebiotics, probiotics, fecal transplantation have yielded encouraging results, advances are needed establish next-generation approaches that precisely target neurobiological mechanisms disorders. Future research must developing personalized treatments, facilitated by innovative therapies technological progress, which account for individual variables such age, sex, drug history, lifestyle. Highlighting potential therapeutic implications targeting microbiota, emphasizes importance integrating into psychiatric studies develop more effective treatment strategies

Language: Английский

Citations

0
Association of 24‐h Energy Intake Behavior With Depressive Symptoms: Findings From the National Health and Nutrition Examination Survey DOI Creative Commons
Jiahui Yin,

M. Gu,

Yong Zhou

et al.

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objective: Appetite changes are a significant clinical feature of depression, with circadian rhythms disruption being crucial mechanism in depression. However, the specific role eating depression remains unclear. This study aimed to assess relationship between energy intake rhythmicity and depressive symptoms. Methods: A total 34,974 noninstitutionalized individuals were recruited from National Health Nutrition Examination Survey. To investigate 24‐h symptoms, covariate‐adjusted sample‐weighted regressions employed. The analyzed various aspects rhythmicity, including proportion non‐meals meal times, as well across meals time periods (morning, midday, afternoon, evening, night, overnight). Results: high (adjusted odds ratio [OR] = 1.11, 95% confidence interval [CI]: 1.08–1.15) was associated higher breakfast daily nonlinearly In participants below 20%, prevalence symptoms decreased by 15% OR 0.85, CI: 0.75–0.96) per each 10% increment intake. U‐shaped identified timing day’s last lowest occurring at 7:48 PM (before PM: adjusted [OR 0.96, 0.94–0.98]; after 1.03–1.20]). Conclusions: Among adults United States, consumed Adequate moderate end‐times linked reduced These results may contribute designing future studies on dietary rhythm interventions for managing

Language: Английский

Citations

0
Association between plant-based diets and depression in older adults with heart disease: the mediating role of sleep disturbances DOI Creative Commons

Yaqun Yu,

Yan Cheng,

Nan Cheng

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Background Depression is not uncommon among older adults with heart diseases and related to poor prognosis at clinical setting. We aim explore the association between plant-based diets depression in disease further investigate mediating role of sleep disturbances this relationship. Methods A cross-sectional sample 2039 were recruited from 2018 Chinese Longitudinal Healthy Longevity Survey (CLHLS). Each individual completed assessments on dietary frequency, depression, quality duration. Plant-based diet index (PDI), healthy (hPDI) unhealthy (uPDI) calculated. Logistic regression models restricted cubic spline curves (RCS) employed relationship disease. Meanwhile, mediation analysis was used roles Results The higher PDI (OR: 0.56, 95% CI: 0.36–0.88) hPDI 0.39, 0.24–0.62), lower risk Conversely, uPDI, 1.76, 1.07–2.92). RCS confirmed a negative linear dose–response PDI, disease, positive trend found uPDI depression. Notably, (Indirect effect: −0.031, mediated proportion: 61%) partially In sex-based subgroup analysis, only associated females. Conclusion This first study suggest significant Sleep plays Optimizing structure improve may help reduce

Language: Английский

Citations

0
The effects and mechanisms of far-infrared ray on depression-like behavior induced by CRS in mice DOI Creative Commons

Yuyan Ling,

Yejun Gao,

Wen Liu

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 225, P. 111348 - 111348

Published: April 17, 2025

Language: Английский

Citations

0
The antidepressant effect of resveratrol may correlate with the anti-inflammatory pathways mediated by Tas2r123 in hippocampus DOI
Hailong Ge,

Lujia Si,

Chen Li

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 156, P. 114670 - 114670

Published: April 19, 2025

Language: Английский

Citations

0