Neuronal damage and inflammatory biomarkers are associated with the affective and chronic fatigue-like symptoms due to end-stage renal disease DOI
Hussein Kadhem Al‐Hakeim,

Basim Abd Al-Raheem Twaij,

Tabarek Hadi Al-Naqeeb

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 347, P. 220 - 229

Published: Nov. 23, 2023

Language: Английский

Gender-related alterations of serum trace elements and neurometabolism in the anterior cingulate cortex of patients with major depressive disorder DOI
Qilin Zhong,

Shunkai Lai,

Jiali He

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 360, P. 176 - 187

Published: May 7, 2024

Language: Английский

Citations

3
Plasma neurofilament light outperforms glial fibrillary acidic protein in differentiating behavioural variant frontotemporal dementia from primary psychiatric disorders DOI Creative Commons
Dhamidhu Eratne, Matthew Kang, Courtney Lewis

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 467, P. 123291 - 123291

Published: Nov. 8, 2024

Language: Английский

Citations

3
Role of T and B lymphocyte cannabinoid type 1 and 2 receptors in major depression and suicidal behaviours DOI Open Access
Michaël Maes,

Muanpetch Rachayon,

Ketsupar Jirakran

et al.

Acta Neuropsychiatrica, Journal Year: 2023, Volume and Issue: 36(5), P. 287 - 298

Published: Sept. 8, 2023

Abstract Early flow cytometry studies revealed T cell activation in major depressive disorder (MDD). MDD is characterised by of the immune-inflammatory response system (IRS) and compensatory immunoregulatory (CIRS), including deficits regulatory (Treg) cells. This study examines number cannabinoid type 1 (CB1) 2 (CB2) receptor-bearing T/B lymphocytes MDD, effects vitro cannabidiol (CBD) administration on CB1/CB2-bearing immunocytes. Using cytometry, we determined percentage CD20+CB2+, CD3+CB2+, CD4+CB2+, CD8+CB2+ FoxP3+CB1+ cells 19 healthy controls 29 patients 5 conditions: baseline, stimulation with anti-CD3/CD28 or without 0.1 µg/mL, 1.0 10.0 µg/mL CBD. CB2+ was significantly higher CD20+ than CD3+ CD4+ CD 8+ Stimulation anti-CD3/CD8 increases CB2-bearing CD3+, CD8+ cells, as well CB1-bearing FoxP3+ There an inverse association between reduced IRS profiles, M1 macrophage, helper-(Th)-1 Th-17 phenotypes. lowered basal CB1+% CB2+%. 33.2% variance depression phenome (including severity depression, anxiety current suicidal behaviours) explained % (positively) CB2+% (inversely). All five immune populations were increased 10 CBD administration. Reductions /CD4+ contribute to homoeostasis while CD20+CB2+% may pathophysiology activating T-independent humoral immunity.

Language: Английский

Citations

8
The molecular fingerprint of neuroinflammation in COVID-19: A comprehensive discussion on molecular mechanisms of neuroinflammation due to SARS-COV2 antigens DOI
Zeinab Deris Zayeri, Mehdi Torabizadeh, Masoud Kargar

et al.

Behavioural Brain Research, Journal Year: 2024, Volume and Issue: 462, P. 114868 - 114868

Published: Jan. 21, 2024

Language: Английский

Citations

2
Neuronal damage and inflammatory biomarkers are associated with the affective and chronic fatigue-like symptoms due to end-stage renal disease DOI
Hussein Kadhem Al‐Hakeim,

Basim Abd Al-Raheem Twaij,

Tabarek Hadi Al-Naqeeb

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 347, P. 220 - 229

Published: Nov. 23, 2023

Language: Английский

Citations

6