Analysis of OCTA Features of the Retina and DTI Features of the Visual Pathway in Patients with Pituitary Adenoma DOI Creative Commons

Zhi Tan,

Zhihui Liao,

Shuying Peng

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 14, 2023

Abstract Purpose The objective of this research is to investigate the ocular neural pathway in individuals affected by pituitary adenoma (PA), combining two distinct methods: diffusion tensor imaging (DTI) and optical coherence tomography angiography (OCTA). relationship between retinal blood flow density fiber conduction function these patients explored. Methods case group comprised 24 who had been recently identified pathologically verified as suffering from PA. A control was assembled, consisting subjects were aligned with terms age gender. All participants underwent OCTA, (OCT), DTI examinations. Differences optic disc, macular OCTA parameters, OCT parameters groups compared, correlations discussed. Results parameters: In group, nerve, chiasm, tract, radiation showed a decline their fractional anisotropy (FA) values when juxtaposed group. Concurrently, apparent coefficient (ADC) for nerve escalated comparison Parameters OCTA: region macula, across all layers, barring deep capillary plexus (DCP), found be lesser subject contrasted reference There notable radial peripapillary capillaries (RPCP) superficial vascular complex (SVC) well set against Correlation: statistically significant correlation existed layers area radiation. Importantly, strong associations network (SVN) ADC measurement FA This suggests that might serve biomarkers assessing visual pathway. Conclusion can assess PA patients, while quantifies function. combination techniques offers novel approach studying injury

Language: Английский

Biomarker identification for bipolar disorders DOI
Francesca Martella, Andrea Caporali, Monica Macellaro

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108823 - 108823

Published: Feb. 1, 2025

Language: Английский

Citations

1
Imaging and Liquid Biopsy for Distinguishing True Progression From Pseudoprogression in Gliomas, Current Advances and Challenges DOI Creative Commons

Kaishu Li,

Qihui Zhu,

Junyi Yang

et al.

Academic Radiology, Journal Year: 2024, Volume and Issue: 31(8), P. 3366 - 3383

Published: April 12, 2024

Rationale and ObjectivesGliomas are aggressive brain tumors with a poor prognosis. Assessing treatment response is challenging because magnetic resonance imaging (MRI) may not distinguish true progression (TP) from pseudoprogression (PsP). This review aims to discuss techniques liquid biopsies used TP PsP.Materials MethodsThis synthesizes existing literature examine advances in techniques, such as diffusion (MRDI), perfusion-weighted (PWI) MRI, biopsies, for identifying or PsP through tumor markers tissue characteristics.ResultsAdvanced including MRDI PWI have proven effective delineating properties, offering valuable insights into glioma behavior. Similarly, biopsy has emerged potent tool tumor-derived biofluids, non-invasive glimpse evolution. Despite their promise, these methodologies grapple significant challenges. Their sensitivity remains inconsistent, complicating the accurate differentiation between PSP. Furthermore, absence of standardized protocols across platforms impedes reliability comparisons, while inherent biological variability adds complexity data interpretation.ConclusionTheir potential applications been highlighted, but gaps remain before routine clinical use. Further research needed develop validate promising methods distinguishing gliomas. Gliomas PsP. characteristics. Advanced interpretation.

Language: Английский

Citations

3
A review of diffusion MRI in mood disorders: mechanisms and predictors of treatment response DOI
Noor Al‐Sharif, Artemis Zavaliangos‐Petropulu, Katherine L. Narr

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 211 - 229

Published: June 20, 2024

Language: Английский

Citations

3
Distinguished Frontal White Matter Abnormalities Between Psychotic and Nonpsychotic Bipolar Disorders in a Pilot Study DOI Creative Commons
Takashi Shiroyama,

Masayuki Maeda,

Hisashi Tanii

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 108 - 108

Published: Jan. 23, 2025

Background/Objectives: Recent studies indicate extensive shared white matter (WM) abnormalities between bipolar disorder (BD) and schizophrenia (SZ). However, the heterogeneity of WM in BD terms presence psychosis remains a critical issue for exploring boundaries SZ. Previous comparing microstructures psychotic nonpsychotic BDs (PBD NPBD) have resulted limited findings, probably due to subtle changes, emphasizing need further investigation. Methods: Diffusion tensor imaging measures were obtained from 8 individuals with PBD, NPBD, 22 healthy controls (HC), matched age, gender, handedness, educational years. Group comparisons conducted using tract-based spatial statistics (TBSS). The most significant voxels showing differences PBD HC TBSS analyses defined as TBSS-ROI subsequently analyzed. Results: Increased radial diffusivity (RD) compared NPBD (p < 0.006; d = 1.706) was observed TBSS-ROI, distributed confined regions some tracts, including body corpus callosum (bCC), left genu CC (gCC), anterior superior corona radiata (ACR SCR). Additionally, exhibited age-associated RD increases (R2 0.822, p 0.001), whereas greater remained consistent across middle age. Conclusions: Preliminary findings this small sample suggest severe frontal disconnection interhemispheric communication, fronto-limbic circuits, cortico-striatal-thalamic loop NPBD. While these results require replication validation larger controlled samples, they provide insights into pathophysiology which is diagnostically located at boundary

Language: Английский

Citations

0
Tract-based structural and functional connectivity abnormalities in bipolar I disorder DOI Creative Commons

Liqian Cui,

Huixing Zeng,

Yixin Chen

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111297 - 111297

Published: Feb. 1, 2025

Language: Английский

Citations

0
Alleviating cognitive impairments in bipolar disorder with a novel DTI-guided multimodal neurostimulation protocol: a double-blind randomized controlled trial DOI Creative Commons
Minmin Wang,

Hetong Zhou,

Xiaomei Zhang

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: June 4, 2025

Language: Английский

Citations

0
Recent Developments in Neuroinformatics and Computational Neuroscience DOI Creative Commons

Polly Jones

Journal of Biomedical and Sustainable Healthcare Applications, Journal Year: 2023, Volume and Issue: unknown, P. 118 - 128

Published: July 5, 2023

In comparison to other natural systems, the temporal dynamics of human brain's growth, structure, and function are notably intricate. The brain is comprised an estimated 86.1 8.0 billion neurons a comparable non-neural glial cells number. Additionally, contains neuronal systems with over 100 trillion connections. modeling, analysis, comprehension these complex structures require use code automation. Neuroinformatics methodologies employed manage, retrieve, integrate copious quantities data produced through clinical documentation, scientific literature, specialized databases. Conversely, computational neuroscience, which draws heavily upon fields biology, physics, mathematics, computation, tackles issues. interdisciplinary field that integrates neuroscience neuroscientific experimentation. This paper functions as introductory guide for individuals who lack familiarity domains neuroinformatics along their consistentsophisticated software, resources, tools.

Language: Английский

Citations

7
Androgen Deprivation Therapy for Prostate Cancer: Focus on Cognitive Function and Mood DOI Creative Commons
Allison B. Reiss,

Shelly Gulkarov,

Aaron Pinkhasov

et al.

Medicina, Journal Year: 2023, Volume and Issue: 60(1), P. 77 - 77

Published: Dec. 30, 2023

Prostate cancer is the second leading cause of death in men United States. Androgen deprivation therapy (ADT) currently primary treatment for metastatic prostate cancer, and some studies have shown that use anti-androgen drugs related to a reduction cognitive function, mood changes, diminished quality life, dementia, possibly Alzheimer’s disease. ADT has potential physiological effects such as white matter integrity negative impact on hypothalamic functions due lowering testosterone levels or blockade downstream androgen receptor signaling by first- second-generation drugs. A comparative analysis patients undergoing Alzheimer identified over 30 shared genes, illustrating common ground mechanistic underpinning symptomatology. The purpose this review was investigate mood, well analyze relationship between evaluation patient ability via neurocognitive testing described. Future should further explore connection among deficits, disturbances, changes occur when hormonal balance altered.

Language: Английский

Citations

6
White and gray matter alterations in bipolar I and bipolar II disorder subtypes compared with healthy controls – exploring associations with disease course and polygenic risk DOI Creative Commons
Katharina Thiel, Hannah Lemke, Alexandra Winter

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 49(5), P. 814 - 823

Published: Feb. 8, 2024

Abstract Patients with bipolar disorder (BD) show alterations in both gray matter volume (GMV) and white (WM) integrity compared healthy controls (HC). However, it remains unclear whether the phenotypically distinct BD subtypes (BD-I BD-II) also exhibit brain structural differences. This study investigated GMV WM differences between HC, BD-I, BD-II, along clinical genetic associations. N = 73 n 63 BD-II patients 136 matched HC were included. Using voxel-based morphometry tract-based spatial statistics, main effects of group fractional anisotropy (FA) analyzed. Associations features or FA calculated using regression models. For but not GMV, we found significant groups. BD-I showed lower ( p tfce-FWE 0.006), primarily anterior corpus callosum. Compared exhibited widespread clusters < 0.001), including almost all major projection, association, commissural fiber tracts. demonstrated although less pronounced 0.049). The results remained unchanged after controlling for features, which no independent associations emerged. Our findings suggest that, at a neurobiological level, may reflect degrees disease expression, increasing microstructure disruption from to BD-I. differential magnitude microstructural was clearly linked variables. These should be considered when discussing classification within spectrum affective disorders.

Language: Английский

Citations

2
Locus coeruleus microstructural integrity is associated with vigilance vulnerability to sleep deprivation DOI Creative Commons
Peng Quan, Tianxin Mao,

Xiaocui Zhang

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(13)

Published: Sept. 1, 2024

Insufficient sleep compromises cognitive performance, diminishes vigilance, and disrupts daily functioning in hundreds of millions people worldwide. Despite extensive research revealing significant variability vigilance vulnerability to deprivation, the underlying mechanisms these individual differences remain elusive. Locus coeruleus (LC) plays a crucial role regulation sleep-wake cycles has emerged as potential marker for deprivation. In this study, we investigate whether LC microstructural integrity, assessed by fractional anisotropy (FA) through diffusion tensor imaging (DTI) at baseline before can predict impaired psychomotor test (PVT) performance during deprivation cohort 60 healthy individuals subjected rigorously controlled in-laboratory study. The findings indicate that with high FA experience less impairment from compared those low FA. accounts 10.8% variance sleep-deprived PVT lapses. Importantly, relationship between is anatomically specific, suggesting integrity may serve biomarker loss.

Language: Английский

Citations

2