Negative valuation of ambiguous feedback may predict near-term risk for suicide attempt in Veterans at high risk for suicide

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 30, 2025

Background Learning from feedback – adapting behavior based on reinforcing and punishing outcomes has been implicated in numerous psychiatric disorders, including substance misuse, post-traumatic stress disorder, depression; an emerging literature suggests it may also play a role suicidality. This study examined whether feedback-based learning task with rewarding, ambiguous outcomes, followed by computational modeling, could improve near-term prospective prediction of suicide attempt high-risk sample. Method Veterans (N=60) at for were tested reward- punishment-based learning, multiple sessions across one-year period. Each session was coded according to the participant had (1) actual (ASA); (2) another suicide-related event (OtherSE) such as suicidal or ideation-related hospital admission (but not ASA); (3) neither (noSE) next 90 days. Computational modeling used estimate latent cognitive variables rates positive negative subjective value feedback. Results Optimal responding reward-based trials positively associated upcoming ASA, remained predictive even after controlling other standard clinical current ideation severity prior attempts. revealed that patients ASA tended view similar weak punishment, while OtherSE noSE both outcome reward. Differences reinforcement neutral Conclusion A provide useful tool help predict risk at-risk patients. While most individuals interpret mildly (a “glass half full” interpretation), those tend empty” interpretation). results are very small sample relatively few events, require replication larger sample, they support biases profile risk.

Language: Английский

Rethinking suicide prediction: From static risk factors to dynamic models

European Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: 96, P. 1 - 2

Published: April 10, 2025

Language: Английский