Nutrients,
Journal Year:
2024,
Volume and Issue:
16(24), P. 4300 - 4300
Published: Dec. 12, 2024
Objectives:
To
explore
whether
the
triglyceride–glucose
(TyG)
index
and
triglyceride
to
high-density
lipoprotein
cholesterol
(TG/HDL-C)
ratio
are
associated
with
trajectories
of
depressive
symptoms.
Methods:
In
this
longitudinal
study,
4215
participants
aged
45
years
older
were
recruited
from
China
Health
Retirement
Longitudinal
Study
2011
2018.
The
symptoms,
measured
by
10-item
Center
for
Epidemiologic
Studies
Depression
Scale
(CESD-10),
identified
using
group-based
trajectory
modeling.
Multinomial
logistic
models
restricted
cubic
spline
analysis
used
investigate
relationships
between
TyG
TG/HDL-C
Stratified
analyses
conducted
based
on
sex,
age,
place
residence,
body
mass
(BMI).
Results:
Five
distinct
symptoms
characterized
stable
low,
moderate,
decreasing,
increasing,
high
during
a
follow-up
7
years.
associations
not
entirely
consistent.
After
adjusting
covariates,
higher
at
baseline
was
lower
odds
being
decreasing
(ORad
=
0.61,
95%
CI:
0.40–0.92)
compared
low
trajectory,
revealed
negative
linear
relationship
likelihood
However,
no
longer
statistically
significant
when
all
confounders
controlled
0.72,
0.50−1.04).
Additionally,
association
observed
among
45–64-year-old
individuals,
female
participants,
those
living
in
rural
areas,
normal
BMI.
Limitations:
This
study
middle-aged
elderly
population
China,
extrapolation
other
regions
populations
requires
further
confirmation.
Conclusions:
Compared
ratio,
may
be
better
predictor
adults.
Considering
that
pathology
depression
progresses
long
term,
our
findings
have
utility
identifying
available
reliable
markers
development
depression.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 7, 2025
Late-onset
depression
(LOD)
refers
to
that
newly
appears
in
elderly
individuals
without
prior
episodes.
Predicting
future
is
crucial
for
mitigating
the
risk
of
major
prospective
patients.
This
study
aims
develop
machine
learning
models
predict
depression.
Using
public
data
from
nationwide
panel
survey
'Korean
Longitudinal
Study
Aging,'
we
employed
latent
growth
modeling
and
mixture
identify
four
classes
trajectories
Korean
population.
Based
on
results
binary
logistic
regression,
selected
12
variables
capable
distinguishing
LOD
population
reference
tested
(ML)
algorithms.
While
most
ML
algorithms
showed
acceptable
predictive
capability,
Random
Forest
Classifier
Gradient
Boosting
demonstrated
superior
performance.
Consequently,
successfully
established
new
ML-based
prediction
programs.
These
programs
could
be
further
developed
into
self-checking
online
tools,
expected
serve
as
decision
support
systems
primary
medical
care
health
screening
services.
International Journal of Geriatric Psychiatry,
Journal Year:
2025,
Volume and Issue:
40(5)
Published: April 25, 2025
ABSTRACT
Background
Rapid
urbanization
in
China
has
raised
significant
public
health
concerns,
particularly
regarding
residents'
physical
and
mental
well‐being.
Effective
interventions
are
urgently
needed
to
address
these
issues.
Objective
This
study
evaluates
the
impact
of
China's
Healthy
City
Pilot
Policy
(HCPP),
introduced
2016,
on
improving
outcomes
examines
demographic
differences
mechanisms
driving
effects.
Methods
Using
data
from
Health
Retirement
Longitudinal
Study
(CHARLS)
2011
2020,
a
difference‐in‐differences
(DID)
approach
was
employed,
along
with
propensity
score
matching
(PSM‐DID),
placebo
tests,
sensitivity
analyses
for
robust
results.
Results
The
HCPP
significantly
enhanced
pilot
cities,
leading
better
self‐rated
health,
lower
medical
expenses,
higher
life
satisfaction,
reduced
depression.
These
benefits
were
most
pronounced
among
elderly,
women,
less‐educated
individuals,
residents
rural
central‐western
regions.
Key
included
increased
exercise,
social
activities,
improved
air
quality.
Conclusion
positively
impacts
urban
especially
vulnerable
groups,
highlighting
urgent
need
integrate
considerations
into
planning
providing
valuable
insights
future
policy
development.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 18, 2024
Abstract
Background
A
global
public
health
issue,
chronic
kidney
disease(CKD)
may
worsen
more
quickly
if
depression
symptoms
overlap.
In
this
study,
a
nomogram
model
was
developed
and
validate
to
predict
in
Chinese
CKD
patients
between
the
ages
of
middle-aged
old.
Methods
7:3
random
split
1571
participants
China
Health
Retirement
Longitudinal
Study
made
into
training
validation
sets.
After
doing
Least
Absolute
Shrinkage
Selection
Operator(LASSO)
multivariate
binary
logistic
regression
analysis
discover
determinants
symptoms.
These
predictors
were
used
create
nomogram,
which
then
evaluated
for
discriminative
power,
predictive
performance,
clinical
applicability
using
receiver
operating
characteristic
(ROC)
curves,
calibration
Hosmer-Leme
show
tests,
decision
curve
(DCA).
Results
The
included
10
predictors,
including
gender,
marital
status,
place
residence,
education
level,
life
satisfaction.
pain,
sleep
disorders,
self-reported
health,
as
well
comorbid
diseases.
Area
under
curve(AUC)
values
sets
were,
turn,
0.889
(95%
CI:
0.869–0.908)
0.869
0.836–0.902),
Hosmer–Lemeshow
test
p
=
0.113
0.259.
curves
Hosmer-Lemeshow
results
verify
model's
capabilities.
Additionally,
(DCA)
illustrated
high
net
benefit
provided
by
model.
Conclusions
We
validated
risk
elderly
patients.
Clinicians
can
accurately
screen
older
having
depressive
evaluation
instrument,
is
important
early
intervention.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 3, 2024
Abstract
Background
Depression
is
a
pressing
public
health
issue
and
may
be
affected
by
multifaceted
urban
living,
yet
the
specific
urbanicity
elements
associated
unclear.
Using
multidimensional
scale,
we
explored
association
between
its
components
with
risk
of
depressive
symptoms.
Methods
This
study
used
data
from
four
waves
China
Health
Retirement
Longitudinal
Study,
including
12,515
participants
aged
≥45
years
at
baseline
in
2011
450
rural
communities,
8,766
7
follow-up.
Multilevel
logistics
regression
Cox
proportional
hazards
models
examined
cross-sectional
longitudinal
associations
Results
Living
areas
highest
tertile
was
61%
lower
symptoms
cross-sectionally
(odds
ratio
(OR):
0.39,
95%
confidence
interval
(CI):
0.30-0.50)
33%
longitudinally
(hazard
(HR):
0.67,
CI:
0.58-0.77)
compared
to
those
living
lowest
urbanicity.
Among
components,
higher
population
density
(OR:
0.92,
0.87-0.97),
better
education
0.94,
0.89-0.99),
transportation
0.95,
0.92-0.98),
sanitation
0.96,
0.93-0.98)
odds
symptoms,
while
greater
educational
socioeconomic
diversity
(OR,
1.08;
CI,
1.03-1.13)
had
opposite
effect.
Better
economic
conditions
(HR:
0.90-0.98)
availability
social
services
(HR,
0.96;
0.93-0.99)
were
reduced
developing
during
Additionally,
differences
found
residents
midlife
older
adults.
Conclusions
Our
findings
underscore
complex
links
among
middle-aged
adults,
highlighting
need
consider
perspective
understand
urbanicity-mental
nexus.
Tailored
planning
policies
should
along
temporal
effectiveness,
urban-rural
disparities,
age
group
differences.