Published: Jan. 1, 2024
Language: Английский
Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Background: Since peripheral leukocytes may contribute to the pathophysiology of stroke, aim this study was elucidate relationship between and stroke outcomes identify which leukocyte subtypes most accurately predict functional poststroke fatigue (PSF) in patients. Methods: A total 788 ischemic patients within 72 h onset disease were admitted our study. Stroke-associated infection (SAI) PSF evaluated according diagnosis standards by a special neurologist. Analyses performed using SPSS 23.0 GraphPad Prism 10.0. Results: Neutrophil-to-lymphocyte ratio (NLR) has discriminative power predicting outcome, area under curve (AUC) NLR distinguish 0.689 (95% confidence interval, 0.646-0.732). Positive correlation found levels NIHSS score on admission (r = 0.2786, p < 0.001). Risk model for outcome constructed age, NIHSS, previous history, triglycerides, glucose hemoglobin levels, thrombolysis treatment, NLR, with an AUC 0.865. Patients who developed SAI both had significantly higher at than those not diagnosed (p 0.0001). risk based parameters including score, lipoprotein(a) 0.751. Conclusions: Higher acute phase might indicate incidence PSF. Therefore, is associated poor prognosis.
Language: Английский
Citations
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The Journal of Physiology, Journal Year: 2024, Volume and Issue: 603(3), P. 759 - 772
Published: Nov. 2, 2024
Post-stroke fatigue is a chronic problem with significant impact on morbidity and mortality, which urgently needs effective treatments. The last decade has seen considerable increase in interest understanding the pathophysiology of developing In this review, following summary theoretical frameworks to understand fatigue, I make case for why phenotyping necessary step fully pathophysiology, turn essential development robust then appraise current post-stroke literature view identifying phenotypes.
Language: Английский
Citations
1
BMJ Open, Journal Year: 2024, Volume and Issue: 14(8), P. e081800 - e081800
Published: Aug. 1, 2024
Structural and functional abnormalities in the cortical-striatal network (CSN) are hypothesised to play a key role pathogenesis of neurological disease-associated fatigue. Some small-scale MRI (fMRI) studies have suggested that poststroke fatigue (PSF) is related focal connectivity (FC) changes. To date, there has been no published large-scale fMRI study on PSF. This planned will examine CSN FC
Language: Английский
Citations
0
Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 4, 2024
Abstract Objective Granger causal analysis (GCA) and amplitude of low‐frequency fluctuation (ALFF) are commonly used to evaluate functional alterations in brain disorders. By combining the GCA ALFF, this study aimed investigate effective connectivity (EC) changes patients with acute ischemic stroke (AIS) anterior circulation occlusion after mechanical thrombectomy (MT). Methods Resting‐state magnetic resonance imaging (rs‐fMRI) data were collected from 43 AIS within 1 week post‐MT 37 healthy controls. ALFF calculated for each participant. Patients further divided into groups based on prognosis perfusion levels. The differences EC compared between controls subgroups patients. Pearson correlations EC, values, clinical characteristics calculated. Results Compared controls, post‐MT, exhibited significant increases left precuneus decreases fusiform gyrus right caudate. Increased contralesional lingual gyrus, putamen, ipsilesional thalamus, thalamus caudate was obsrved, while decrease found medial superior frontal gyrus. particularly notable groups, significantly lower poorly perfused group. values also positively correlated National Institutes Health Stroke Scale (NIHSS) scores pre‐MT. Interpretation In patients, nucleus central observed characterized by decreased outputs increased inputs. These indicate remodeling cortico‐basal ganglia‐thalamic‐cortical pathway.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0