Elevated remnant cholesterol and the risk of prevalent major depressive disorder: a nationwide population-based study DOI Creative Commons
Shiyi Tao,

Lintong Yu,

Jun Li

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 14, 2024

Background Remnant cholesterol (RC) has received increasing attention due to its association with a variety of diseases. However, comprehensive population-based studies elucidating the relationship between RC and major depressive disorder (MDD) are limited. The current study aimed determine MDD in US adults. Methods Cross-sectional data adults complete depression information were obtained from National Health Nutrition Examination Survey (NHANES) 2005-2018. was evaluated using Patient Questionnaire (PHQ-9). Multivariate logistic regression, sensitivity analysis, spline smoothing plot method conducted explore depression. cut-off point calculated recursive partitioning analysis when segmenting effects emerged. area under receiver operating characteristic (ROC) curve (AUC), calibration curve, Hosmer-Lemeshow test, decision (DCA), clinical impact (CIC) employed evaluate performance identifying MDD. Subgroup analyses interaction tests performed whether stable different populations. Results A total 9,173 participants enrolled higher quartile tended have PHQ-9 score prevalence In fully adjusted model, positive both observed (β=0.54, 95% CI 0.26~0.82; OR=1.43, 1.15~1.78). Participants highest had 0.42-unit (β=0.42, 0.15~0.69) significantly 32% risk than those lowest (OR=1.32, 1.05~1.66). Spline further confirmed non-linear ROC (AUC=0.762), test ( χ 2 = 6.258, P =0.618), all indicated high goodness-of-fit multivariate model. DCA CIC similarly demonstrated overall net benefit for suggested that remained across subgroups unaffected by other factors diabetes, hypertension, or hyperlipidemia. Conclusion An elevated is associated prevalent among adults, especially present results management levels comorbidities may contribute alleviating occurrence

Language: Английский

Overweight in mediating the association between depression and new-onset diabetes: A population-based research from Health and Retirement Study DOI
Zihao Zhang, Shuaijun Yue, Meng Su

et al.

World Journal of Diabetes, Journal Year: 2025, Volume and Issue: 16(3)

Published: Jan. 20, 2025

BACKGROUND Several studies have suggested a close link between depression, overweight, and new-onset diabetes, particularly among middle-aged older populations; however, the causal associations remain poorly understood. AIM To investigate role of overweight in mediating association depression diabetes populations. METHODS Data 9426 individuals aged ≥ 50 years from 1998-2016 Health Retirement Study database were analyzed. Weighted logistic regression was employed to obtain odds ratios (ORs) 95% confidence intervals (95%CIs) for Mediation analysis Sobel test used effects risk diabetes. RESULTS New-onset identified 23.6% study population. Depression significantly associated with (OR: 1.18, 95%CI: 1.03-1.35, P value: 0.014). Further adjustment attenuated effect on 1.14 (95%CI: 1.00-1.30, = 0.053), significant (P 0.003). The mediation demonstrated that accounted 61% having partially depression-to-diabetes pathway. CONCLUSION not necessarily direct complication depression; rather, led behaviors increase and, consequently,

Language: Английский

Citations

0
Genetic Susceptibility to Depression is Associated with Increased Risk of Cardiometabolic Diseases: A Systematic Review and Meta-Analysis of 38 Mendelian Randomisation Studies DOI

Tabinda Jabeen,

Emma Todd, Sarah Gauci

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Exploring the bidirectional causal association between Sleep Apnea Syndrome and Depression: A Mendelian randomization study involving gut microbiota, serum metabolites, and inflammatory factors DOI Creative Commons
Kaiyuan Li, Peng Liu, Yuhao Zeng

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 366, P. 308 - 316

Published: Aug. 30, 2024

This study aimed to investigate the potential causal association between Sleep Apnea Syndrome (SAS) and Depression, focusing on roles of gut microbiota, serum metabolites, inflammatory factors in these conditions.

Language: Английский

Citations

2
Temporal Relationship between HbA1c and Depressive Symptom Trajectories in a Longitudinal Cohort Study: The Mediating Role of Healthy Lifestyles DOI Creative Commons
Na Zeng, Chao Li,

Huan Mei

et al.

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 780 - 780

Published: July 31, 2024

This study analyzed China Health and Retirement Longitudinal Study data to explore the HbA1c-depression link, including depressive trajectories, while considering mitigating impact of healthy lifestyles. Cross-lagged panel models group-based trajectory modeling were performed investigate temporal relationship between HbA1c levels symptoms, as well trajectories. Structural equation used assess mediating effects The mean age participants was 57.66 ± 9.04 years, with 53.68% being female. Analyzing 8826 across three waves, we observed a significant prediction subsequent symptoms by preceding (β = 0.296;

Language: Английский

Citations

0
Elevated remnant cholesterol and the risk of prevalent major depressive disorder: a nationwide population-based study DOI Creative Commons
Shiyi Tao,

Lintong Yu,

Jun Li

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 14, 2024

Background Remnant cholesterol (RC) has received increasing attention due to its association with a variety of diseases. However, comprehensive population-based studies elucidating the relationship between RC and major depressive disorder (MDD) are limited. The current study aimed determine MDD in US adults. Methods Cross-sectional data adults complete depression information were obtained from National Health Nutrition Examination Survey (NHANES) 2005-2018. was evaluated using Patient Questionnaire (PHQ-9). Multivariate logistic regression, sensitivity analysis, spline smoothing plot method conducted explore depression. cut-off point calculated recursive partitioning analysis when segmenting effects emerged. area under receiver operating characteristic (ROC) curve (AUC), calibration curve, Hosmer-Lemeshow test, decision (DCA), clinical impact (CIC) employed evaluate performance identifying MDD. Subgroup analyses interaction tests performed whether stable different populations. Results A total 9,173 participants enrolled higher quartile tended have PHQ-9 score prevalence In fully adjusted model, positive both observed (β=0.54, 95% CI 0.26~0.82; OR=1.43, 1.15~1.78). Participants highest had 0.42-unit (β=0.42, 0.15~0.69) significantly 32% risk than those lowest (OR=1.32, 1.05~1.66). Spline further confirmed non-linear ROC (AUC=0.762), test ( χ 2 = 6.258, P =0.618), all indicated high goodness-of-fit multivariate model. DCA CIC similarly demonstrated overall net benefit for suggested that remained across subgroups unaffected by other factors diabetes, hypertension, or hyperlipidemia. Conclusion An elevated is associated prevalent among adults, especially present results management levels comorbidities may contribute alleviating occurrence

Language: Английский

Citations

0