SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression DOI
Hongbo Yu, Xinping Li, Bo Ning

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 328 - 340

Published: Oct. 29, 2024

Coronary heart disease (CHD) combined with anxiety or depression is increasingly receiving attention in the clinical field of cardiology, and exploring comorbidity pathological mechanisms cardiovascular psychological disorders a hot research topic for scholars this field. Current suggests that Silent Information Regulatory Factor 1 (SIRT1) may serve as potential biomarker mechanism treatment CHD depression. SIRT1 considered promising therapeutic target depression, ability to regulate inflammatory cytokine levels, alleviate oxidative stress damage, activate multiple signalling pathways, reduce platelet hyperresponsiveness, exert neuroprotective cardioprotective effects. In comprehensive review, we deeply studied structure, function, SIRT1, discussed its protective effects nervous system. The latest progress SIRT1's role was emphasised, including specific regulating response, alleviating stress, mediating various pathways. addition, article also summarises patients

Language: Английский

Photobiomodulation in experimental models of Alzheimer’s disease: state-of-the-art and translational perspectives DOI Creative Commons
Zhihai Huang, Michael R. Hamblin, Quanguang Zhang

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: May 21, 2024

Abstract Alzheimer’s disease (AD) poses a significant public health problem, affecting millions of people across the world. Despite decades research into therapeutic strategies for AD, effective prevention or treatment this devastating disorder remains elusive. In review, we discuss potential photobiomodulation (PBM) preventing and alleviating AD-associated pathologies, with focus on biological mechanisms underlying therapy. Future directions guidance clinical practice non-invasive non-pharmacological therapy are also highlighted. The available evidence indicates that different paradigms, including transcranial systemic PBM, along recently proposed remote all could be promising AD. PBM exerts diverse effects, such as enhancing mitochondrial function, mitigating neuroinflammation caused by activated glial cells, increasing cerebral perfusion, improving glymphatic drainage, regulating gut microbiome, boosting myokine production, modulating immune system. We suggest may serve powerful intervention

Language: Английский

Citations

10
New insights into the effects of serotonin on Parkinson's disease and depression through its role in the gastrointestinal tract DOI Creative Commons
María Sancho‐Alonso, Unai Sarriés-Serrano, Lluís Miquel-Rio

et al.

Spanish Journal of Psychiatry and Mental Health, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Neuropsychiatric and neurodegenerative disorders are frequently associated with gastrointestinal (GI) co-pathologies. Although the central enteric nervous systems (CNS ENS, respectively) have been studied separately, there is increasing interest in factors that may contribute to conditions affecting both systems. There compelling evidence serotonin (5-HT) play an important role several gut–brain disorders. It well known 5-HT essential for development functioning of CNS. However, most body's produced GI tract. A deeper understanding specific effects on provide basis new therapeutic targets. This review summarizes current data focusing ENS motility, particular emphasis novel aspects signaling where CNS comorbidities common, such as Parkinson's disease depressive

Language: Английский

Citations

4
AI Perspectives on the Present and Future of Antidepressant Pharmaceutical Treatment Based on Anti-inflammatory Strategies: A Scoping Review of Randomised Controlled Clinical Trials DOI
Bo Yan, Yifei Chen, Hong Liang

et al.

Published: Jan. 26, 2025

Recently, a novel concept of 'anti-inflammatory-based pharmacotherapy' has been developed. The aim this scoping review was precisely to explore in depth the current status inflammation randomised controlled clinical trial studies depression. PubMed systematically searched from inception December 11 2024. Studies that researches on treatment depression based anti-inflammatory strategies were included. Study characteristics and outcomes extracted organized thematically. reports trials included, which accumulated 119 depressed patients. All found there is connection between effects drugs treating large decrease levels inflammatory markers blood patients compared before treatment. Three markers, CRP, IL-6 TNF-alpha, most frequently mentioned. strategy drug administration did not differ fundamentally previous traditional antidepressant combined with psychotherapy. At present, use for pharmacological limited research value poor feasibility. potential feasibility future lies application an integrated AI platform assist strategies. Registration DOI: https://doi.org/10.17605/OSF.IO/A64GC

Language: Английский

Citations

0
Low-dose cannabidiol treatment prevents chronic stress-induced phenotypes and is associated with multiple synaptic changes across various brain regions DOI Creative Commons

Sara Borràs‐Pernas,

Anna Sancho‐Balsells,

Lisa Patterer

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110526 - 110526

Published: May 1, 2025

Major Depressive Disorder (MDD) is a heterogeneous and debilitating mood disorder often associated with stress. Although current treatments are available, they remain ineffective for approximately 30% of affected individuals frequently accompanied by undesirable side effects. Cannabidiol (CBD) has emerged as potential safe therapeutic option alleviating depressive symptoms; however, the underlying molecular mechanisms through which this compound exerts its beneficial effects not yet fully understood. In study, we demonstrate that very low dose CBD (1 mg/kg) can partially reverse some sequelae induced chronic stress, well-established mouse model used to simulate depressive-like symptoms. Using mass spectrometry analyze different brain regions, observed several improvements following treatment, particularly in medial prefrontal cortex (mPFC), across multiple neurotransmission systems (including glutamatergic serotonergic pathways). Microstructural experiments, utilizing double-labeling F-Actin VGlut1-positive clusters, revealed complete restoration mature synapses mPFC mice treated CBD. conclusion, our findings indicate effective counteracting adverse possibly synaptic remodeling excitatory mPFC.

Language: Английский

Citations

0
Expansion of the neocortex and protection from neurodegeneration by in vivo transient reprogramming DOI Creative Commons
Yiru Shen,

Sofía Zaballa,

Xavier Bech

et al.

Cell stem cell, Journal Year: 2024, Volume and Issue: 31(12), P. 1741 - 1759.e8

Published: Oct. 18, 2024

Language: Английский

Citations

3
SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression DOI
Hongbo Yu, Xinping Li, Bo Ning

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 328 - 340

Published: Oct. 29, 2024

Coronary heart disease (CHD) combined with anxiety or depression is increasingly receiving attention in the clinical field of cardiology, and exploring comorbidity pathological mechanisms cardiovascular psychological disorders a hot research topic for scholars this field. Current suggests that Silent Information Regulatory Factor 1 (SIRT1) may serve as potential biomarker mechanism treatment CHD depression. SIRT1 considered promising therapeutic target depression, ability to regulate inflammatory cytokine levels, alleviate oxidative stress damage, activate multiple signalling pathways, reduce platelet hyperresponsiveness, exert neuroprotective cardioprotective effects. In comprehensive review, we deeply studied structure, function, SIRT1, discussed its protective effects nervous system. The latest progress SIRT1's role was emphasised, including specific regulating response, alleviating stress, mediating various pathways. addition, article also summarises patients

Language: Английский

Citations

0