Unique genetic and risk-factor profiles in clusters of major depressive disorder-related multimorbidity trajectories

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 21, 2024

Abstract The heterogeneity and complexity of symptom presentation, comorbidities genetic factors pose challenges to the identification biological mechanisms underlying complex diseases. Current approaches used identify subtypes major depressive disorder (MDD) mainly focus on clinical characteristics that cannot be linked specific models. Here, we examined multimorbidities MDD with distinct non-genetic factors. We leveraged dynamic Bayesian network determine a minimal set relevant identified seven clusters disease-burden trajectories throughout lifespan among 1.2 million participants from cohorts in UK, Finland, Spain. had clear protective- risk-factor profiles as well age-specific courses driven by inflammatory processes, comprehensive map heritability correlations these was revealed. Our results can guide development personalized treatments for based unique genetic, patients.

Language: Английский

Childhood maltreatment and depression: mediating role of lifestyle factors, personality traits, adult traumas, and social connections among middle-aged and elderly participants

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 30, 2025

Accumulating evidence has supported the associations between childhood maltreatment and increased risk of depression; however, underlying mechanisms remain largely unclear. We aimed to explore potential role lifestyle factors, personality traits, adult traumas, social connections in association depression. used a nationwide cohort data from UK Biobank, involving half million participants aged 37-73 years, recruited across 22 centers 2006 2010. Participants with complete information on experiences who were free depression included. The Childhood Trauma Questionnaire was calculate for five subtypes: physical neglect, emotional sexual abuse, abuse. Multivariate logistic regression models implemented examine A path analysis using structural equation modeling (SEM) then performed assess mediating effects connections. During mean follow-up 13.88 5545 developed Of 109,401 included study (mean [standard deviation] age, 55.75 [7.76] years; 58,315 females [53.30%]), 48,923 reported experiencing at least one form maltreatment. observed that higher scores (odds ratio [OR] 1.28, 95% confidence interval [CI] 1.25-1.31) all subtypes (physical neglect: 1.46, 1.36-1.56; 1.78, 1.67-1.89; abuse: 1.48, 1.36-1.61; 1.37, 1.29-1.47; 1.88, 1.76-2.00) associated an SEM results indicated effect partly mediated by factors (β - 0.15, P < 0.001), traits 0.12, traumas 0.50, 0.19, rather than having direct found environmental such as lifestyle, personality, mediate relationship middle-aged elderly people. These findings suggest addressing these may be relevant mental health interventions individuals history

Language: Английский

Association of single nucleotide polymorphisms and gene-environment interactions with major depressive disorder in Chinese

Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e37504 - e37504

Published: Sept. 1, 2024

Language: Английский