Vascular depression: A comprehensive exploration of the definition, mechanisms, and clinical challenges DOI Creative Commons
Siyuan Wu, Yi Zhang, Yiyu Lu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106946 - 106946

Published: May 1, 2025

Vascular depression (VaDep), which was proposed over two decades ago, is a distinct subtype of primarily observed in patients with stroke and cerebral small-vessel disease characterized by white matter hyperintensities; however, the lack standardized diagnostic criteria consensus limits its clinical application. This review explores pathological conditions vascular risk factors that may precipitate VaDep, particularly relation to disease. VaDep distinguished unique pathophysiological mechanisms treatment responses. We categorize these into three groups: 1) macroscopic mechanisms, including aging, hypoperfusion, blood-brain barrier disruption, neural circuit dysfunction; 2) microscopic involving inflammatory response, hypothalamic-pituitary-adrenal axis dysregulation, impaired monoamine synthesis, mitochondrial 3) undetermined such as microbiota-gut-brain dysbiosis. These insights support subtype, differentiating it from late-life major depressive disorder. Treatment challenging, often exhibit resistance conventional antidepressants. Addressing protecting integrity are essential for effective management. Future research should validate develop novel therapeutic approaches improve outcomes.

Language: Английский

Curvilinear relationship between life's crucial 9 and metabolic syndrome in U.S. adults: a cross-sectional study DOI Creative Commons
Wei Wang, Chunqi Jiang, Pingping Yu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Metabolic Syndrome (MetS) is closely linked to cardiovascular disease. However, no studies have examined the relationship between Life’s Crucial 9 (LC9) and MetS. Our goal investigate potential association LC9 Methods We employed a weighted multivariate logistic regression model evaluate LC9, health behavior score, factors To assess robustness of this association, we conducted sensitivity analyses. Furthermore, utilized smooth curve fitting curvilinear relationships pinpoint inflection points, integrated recursive partitioning algorithms with two-stage linear model. Additionally, performed stratified analyses explore heterogeneity across different population subgroups. Results study included total 28,555 participants. In that accounted for all covariates, OR MetS was 0.941 (0.939, 0.944), indicating significant negative correlation two. Smooth analysis confirmed MetS, an point at 70.56. The evident both before after point, more pronounced effect point. Subgroup Health score as well by age, sex, BMI, showed groups exhibited consistent overall pattern. Conclusion scores metabolic syndrome indicates higher act protective factor against

Language: Английский

Citations

0
Vascular depression: A comprehensive exploration of the definition, mechanisms, and clinical challenges DOI Creative Commons
Siyuan Wu, Yi Zhang, Yiyu Lu

et al.

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106946 - 106946

Published: May 1, 2025

Vascular depression (VaDep), which was proposed over two decades ago, is a distinct subtype of primarily observed in patients with stroke and cerebral small-vessel disease characterized by white matter hyperintensities; however, the lack standardized diagnostic criteria consensus limits its clinical application. This review explores pathological conditions vascular risk factors that may precipitate VaDep, particularly relation to disease. VaDep distinguished unique pathophysiological mechanisms treatment responses. We categorize these into three groups: 1) macroscopic mechanisms, including aging, hypoperfusion, blood-brain barrier disruption, neural circuit dysfunction; 2) microscopic involving inflammatory response, hypothalamic-pituitary-adrenal axis dysregulation, impaired monoamine synthesis, mitochondrial 3) undetermined such as microbiota-gut-brain dysbiosis. These insights support subtype, differentiating it from late-life major depressive disorder. Treatment challenging, often exhibit resistance conventional antidepressants. Addressing protecting integrity are essential for effective management. Future research should validate develop novel therapeutic approaches improve outcomes.

Language: Английский

Citations

0