Associations of Ultra-Processed Food Intake and Its Circulating Metabolomic Signature with Mental Disorders in Middle-Aged and Older Adults DOI Open Access

Shenghao Yuan,

Tingting Zhu, Jiawei Gu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1582 - 1582

Published: May 4, 2025

Background: The global rise in ultra-processed food (UPF) consumption and the persistent burden of mental disorders have raised growing public health concerns. Emerging evidence suggests that unfavorable dietary patterns, particularly with high UPF intake, contribute to development disorders. Objective: To assess associations UPF-related metabolic signatures Methods: In this population-based cohort study 30,059 participants from UK Biobank, we first identified a plasma signature associated intake leveraging nuclear magnetic resonance metabolomics. We then applied Cox logistic regression models investigate both its incident specific psychological symptoms, respectively. Results: Higher was significantly increased risks overall disorder (hazard ratio per 10% increment [95% confidence interval]: 1.04 [1.02, 1.06]), depressive (1.14 [1.08, 1.20]), anxiety (1.12 [1.06, 1.18]), substance use (1.06 [1.01, 1.11]), as well several symptoms including suicidal ideation (odds ratios 1.12 [1.03, 1.16]) feeling (1.05 1.09]). Similarly, independently elevated these outcomes partially mediated between Conclusions: These findings highlighted potential pathways underlying neuropsychiatric underscored importance quality health.

Language: Английский

Associations of Ultra-Processed Food Intake and Its Circulating Metabolomic Signature with Mental Disorders in Middle-Aged and Older Adults DOI Open Access

Shenghao Yuan,

Tingting Zhu, Jiawei Gu

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1582 - 1582

Published: May 4, 2025

Background: The global rise in ultra-processed food (UPF) consumption and the persistent burden of mental disorders have raised growing public health concerns. Emerging evidence suggests that unfavorable dietary patterns, particularly with high UPF intake, contribute to development disorders. Objective: To assess associations UPF-related metabolic signatures Methods: In this population-based cohort study 30,059 participants from UK Biobank, we first identified a plasma signature associated intake leveraging nuclear magnetic resonance metabolomics. We then applied Cox logistic regression models investigate both its incident specific psychological symptoms, respectively. Results: Higher was significantly increased risks overall disorder (hazard ratio per 10% increment [95% confidence interval]: 1.04 [1.02, 1.06]), depressive (1.14 [1.08, 1.20]), anxiety (1.12 [1.06, 1.18]), substance use (1.06 [1.01, 1.11]), as well several symptoms including suicidal ideation (odds ratios 1.12 [1.03, 1.16]) feeling (1.05 1.09]). Similarly, independently elevated these outcomes partially mediated between Conclusions: These findings highlighted potential pathways underlying neuropsychiatric underscored importance quality health.

Language: Английский

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