The Legalome: Microbiology, Omics and Criminal Justice
Microbial Biotechnology,
Journal Year:
2025,
Volume and Issue:
18(3)
Published: March 1, 2025
ABSTRACT
Advances
in
neuromicrobiology
and
related
omics
technologies
have
reinforced
the
idea
that
unseen
microbes
play
critical
roles
human
cognition
behaviour.
Included
this
research
is
evidence
indicating
gut
microbes,
through
direct
indirect
pathways,
can
influence
aggression,
anger,
irritability
antisocial
Moreover,
manufacture
chemicals
are
known
to
compromise
cognition.
For
example,
recent
court
decisions
United
States
Europe
acknowledge
produce
high
levels
of
ethanol,
without
consumption
alcohol
by
defendants.
The
dismissal
driving
while
intoxicated
charges
these
cases—so‐called
auto‐brewery
syndrome—highlights
way
which
microbiome
knowledge
will
enhance
precision,
objectivity
fairness
our
legal
systems.
Here
opinion
essay,
we
introduce
concept
‘legalome’—the
application
science
forensic
psychiatry
criminal
law.
We
argue
rapid
pace
microbial
discoveries,
including
those
challenge
ideas
free
moral
responsibility,
necessitate
a
reconsideration
traditional
doctrines
justifications
retributive
punishment.
implications
extend
beyond
courtroom,
challenging
us
reconsider
how
environmental
factors—from
diet
socioeconomic
conditions—might
shape
preventative
rehabilitative
efforts
their
effects
on
microbiome.
Language: Английский
The Interplay Between Depression, Probiotics, Diet, Immunometabolic Health, the Gut, and the Liver—A Secondary Analysis of the Pro-Demet Randomized Clinical Trial
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4024 - 4024
Published: Nov. 24, 2024
(1)
Background:
Depression,
metabolic
alternations,
and
liver
diseases
are
highly
comorbid.
Studies
have
shown
that
probiotics
might
be
helpful
in
the
treatment
of
above-mentioned
states.
The
aim
this
secondary
analysis
was
to
search
for
possible
predictors
probiotics'
efficacy
on
liver-related
outcome
measures.
(2)
Methods:
Data
from
92
subjects
a
randomized
clinical
trial
effect
depression
were
analyzed.
shift
steatosis
fibrosis
indices
assessed
context
baseline
immunometabolic,
psychometric,
dietary,
intestinal
permeability
factors.
Correlation
linear
regression
models
used.
(3)
Results:
A
total
30%
variance
improvement
score
aspartate
transferase
platelet
ratio
index
explained
by
probiotic
use,
higher
pre-intervention
triglycerides,
cholesterol,
C-reactive
protein
levels,
increased
cereal
intake,
lower
consumption
sweets.
Then,
model
change
alanine
indicated
efficient
when
used
with
basal
levels
markers.
(4)
Conclusions:
Probiotics
being
along
healthy
diet
may
provide
additional
benefits,
such
as
decreased
cardiovascular
risk,
patients
measures
consistent
immunometabolic
form
depression.
Probiotic
augmentation
useful
protection
among
suspected
"leaky
gut"
syndrome.
ClinicalTrials.gov:
NCT04756544.
Language: Английский