Preoperative continuation vs. discontinuation of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers on early cognitive function in elderly patients undergoing noncardiac surgery: a randomized controlled trial DOI Creative Commons
Xiaohan Wang, Yanan Yan, Yurong Liu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 17, 2025

To evaluate the effect of preoperative continuation vs. discontinuation angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on early cognitive function in elderly patients undergoing noncardiac surgery. This prospective randomized controlled study was performed at Affiliated Hospital Xuzhou Medical University. Elderly aged 65 years or older, scheduled for elective surgery under general anesthesia, receiving long-term ACEI/ARBs therapy were randomly assigned to either continue discontinue morning The primary outcome postoperative function, assessed via neuropsychological tests including Auditory Verbal Learning Test-Huashan (AVLT-H), Clock Drawing Test (CDT), Number Connection (NCT), Digit Span (DST) preoperatively day 1 (POD1). Secondary outcomes included intraoperative hypotension, use phenylephrine, fluid administration, incidence hypertension, length hospital stay. NCT scores discontinued group showed a significant decline POD1 compared baseline (p = 0.038). Both groups exhibited an increase immediate recall from 0.003 p 0.002, respectively). continued short-delayed 0.007). However, there no differences between two > 0.05). ACEI/ARB had fewer episodes hypotension 0.037) lower requirements phenylephrine 0.016), despite higher hypertension 0.012). received larger volume crystalloid fluids during 0.020). No observed colloid administered There stay Preoperative did not significantly affect patients.

Language: Английский

Preoperative continuation vs. discontinuation of angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers on early cognitive function in elderly patients undergoing noncardiac surgery: a randomized controlled trial DOI Creative Commons
Xiaohan Wang, Yanan Yan, Yurong Liu

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 17, 2025

To evaluate the effect of preoperative continuation vs. discontinuation angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on early cognitive function in elderly patients undergoing noncardiac surgery. This prospective randomized controlled study was performed at Affiliated Hospital Xuzhou Medical University. Elderly aged 65 years or older, scheduled for elective surgery under general anesthesia, receiving long-term ACEI/ARBs therapy were randomly assigned to either continue discontinue morning The primary outcome postoperative function, assessed via neuropsychological tests including Auditory Verbal Learning Test-Huashan (AVLT-H), Clock Drawing Test (CDT), Number Connection (NCT), Digit Span (DST) preoperatively day 1 (POD1). Secondary outcomes included intraoperative hypotension, use phenylephrine, fluid administration, incidence hypertension, length hospital stay. NCT scores discontinued group showed a significant decline POD1 compared baseline (p = 0.038). Both groups exhibited an increase immediate recall from 0.003 p 0.002, respectively). continued short-delayed 0.007). However, there no differences between two > 0.05). ACEI/ARB had fewer episodes hypotension 0.037) lower requirements phenylephrine 0.016), despite higher hypertension 0.012). received larger volume crystalloid fluids during 0.020). No observed colloid administered There stay Preoperative did not significantly affect patients.

Language: Английский

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