Screening of Anti-inflammatory and Analgesic Activities of Caulerpa Racemosa from the Bay of Bengal, Bangladesh DOI Creative Commons

Khadiza Chowdhury,

Md. Abdul Alim, Nazia Zaman

et al.

Bioresearch Communications, Journal Year: 2023, Volume and Issue: 9(2), P. 1330 - 1339

Published: June 20, 2023

Caulerpa spp; is a remarkably potential seaweed due to its pharmacological importance, high nutritional compositions, biological activities , and human health benefit. It species of ulvophyte green algae inhabiting mostly in the intertidal shallow sub-tidal coastal regions Asia- Pacific commonly consumed South-East Asia for contents vitamins minerals. Besides culinary uses, it well-reported antibacterial, antifungal, diabetes, blood pressure, lipid-lowering properties. However, date, no extensive assessment diversity, distribution, activity assay these seaweeds found on Bangladesh coast has been carried out. This study aimed at anti-inflammatory analgesic studies 50% ethanolic extract racemosa. collected from St. Martin's Island, Bangladesh. Consequently, secondary metabolites such as steroids, flavonoids, glycoside, saponin were also detected phytochemical assay. In present study, 25 & 50mg/kg body weight C. racemosa was used hot plate, acetic acid, formic carrageenan-induced paw edema Swiss albino mice showing significant properties. Bioresearch Commu. 9(2): 1330-1339, 2023 (July)

Language: Английский

Marine algae‐derived characterized bioactive compounds as therapy for cancer: A review on their classification, mechanism of action, and future perspectives DOI
Wei Liao,

Yaobin Chen,

Shuo Shan

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(8), P. 4053 - 4080

Published: June 19, 2024

Abstract In 2022, there were around 20 million new cases and over 9.7 cancer‐related deaths worldwide. An increasing number of metabolites with anticancer activity in algae had been isolated identified, which promising candidates for cancer therapy. Red are well‐known the production brominated metabolites, including terpenoids phenols, have capacity to induce cell toxicity. Some non‐toxic biological macromolecules, polysaccharides, distinct secondary found many algae, particularly green algae. They possess activities by inhibiting tumor angiogenesis, stimulating immune response, inducing apoptosis. However, structure–activity relationship between these components antitumor activity, as well certain taxa within remains relatively unstudied. This work is based on reports published from 2003 2024 PubMed ISI Web Science databases. A comprehensive review characterized algal active compounds, together their structure mechanism action was performed. Also, preliminarily summarized better assess potential properties a natural, safe bioactive product be used an alternative treatment cancers, leading opportunities drug discovery.

Language: Английский

Citations

7
Green Seaweed Caulerpa racemosa as a Novel Non-Small Cell Lung Cancer Inhibitor in Overcoming Tyrosine Kinase Inhibitor Resistance: An Analysis Employing Network Pharmacology, Molecular Docking, and In Vitro Research DOI Creative Commons
Vincent Lau, Fahrul Nurkolis, Moon Nyeo Park

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(6), P. 272 - 272

Published: June 12, 2024

The marine environment provides a rich source of distinct creatures containing potentially revolutionary bioactive chemicals. One these organisms is

Language: Английский

Citations

5
Antiaging Potential of Lipophilic Extracts of Caulerpa prolifera DOI Creative Commons
Gonçalo P. Rosa, Maria do Carmo Barreto, Ana M. L. Seca

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 83 - 83

Published: Feb. 14, 2025

The cosmeceutical industry has increasingly turned its attention to marine macroalgae, recognizing their significant bioactive potential as sources of natural compounds for skincare applications. A growing number products now incorporate extracts or isolated from various macroalgae species. However, many species remain underexplored, highlighting a valuable opportunity further research. Among these, Caulerpa prolifera (Forsskål) J.V. Lamouroux emerged promising candidate This study provides the most comprehensive phytochemical assessment C. date, revealing source and compounds. analysis identified key components lipophilic profile, predominantly saturated unsaturated fatty acids, alongside di-(2-ethylhexyl) phthalate-an endocrine disruptor potentially biosynthesized bioaccumulated by algae. While crude extract exhibited moderate tyrosinase inhibitory activity, overall antioxidant capacity was limited. Fractionation extract, however, yielded subfractions with distinct bioactivities linked changes in chemical composition. Notably, enhanced activities against elastase collagenase were observed enriched 1-octadecanol only traces phthalate. Conversely, activity diminished loss specific such β-sitosterol, erucic acid, nervonic lignoceric acid. work advances understanding relationship between composition bioactivities, emphasizing ingredients, leading more valorization this macroalga.

Language: Английский

Citations

0
Controllable preparation of hydrophilic alendronate hydroxyapatite quercetin multifunctional polylactic acid microspheres for treating osteoarthritis DOI Creative Commons

Lifei Yang,

Jiawei Yao,

D. Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143071 - 143071

Published: April 1, 2025

Language: Английский

Citations

0
Nutritional Properties, Antioxidant Activity, and Heavy Metal Accumulation in Selected Marine Macro-Algae Species of Sri Lanka DOI Creative Commons

Viraji Bandara Warnasooriya,

Sadhisha Gunawardena, Pabodha Weththasinghe

et al.

Nutraceuticals, Journal Year: 2024, Volume and Issue: 4(1), P. 50 - 64

Published: Jan. 18, 2024

In recent years, the emergence of drug resistance and sensitivity in leading diseases has heightened global interest natural nutraceuticals as primary health supplements. However, comprehensive scientific scrutiny is essential before marketing these this study, we assessed nutritional composition, antioxidant activities, trace metal accumulation eleven selected Sri Lankan coastal seaweed species. Gracilaria corticata had highest (p < 0.05) ash crude fiber content among Protein ranged from 4.87% to 23.67% (DW), with Ulva rigida displaying 0.05). Crude fat 0.09% 4.13% Cladophora herpestica having content. Sargassam cinereum, Turbinaria ornata Sargassum crassifolium TPC (51.32 ± 0.61–28.90 2.68 mg/GAE g) radical scavenging activity compared other seaweeds. The study findings indicate that most studied metals seaweeds exceeded WHO-recommended levels. Aluminum was accumulated metals. Toxic heavy metals, such arsenic, cadmium chromium, levels all surpassed WHO limits. While displayed acceptable properties, presence poses a potential risk consumers. Products using may have lower quality. Thus, underscores need for investigation developing high-quality food products or supplements

Language: Английский

Citations

2
Unleashing the Potential of Marine Algae in Cancer Prevention and Treatment Through Combination of Tradition and Innovation DOI
Fahrul Nurkolis,

Dionysius Subali,

Nurpudji Astuti Taslim

et al.

Interdisciplinary cancer research, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Cancer is a global health challenge, with rapidly rising incidence and significant economic burden. The urgent need for innovative approaches to cancer prevention treatment underscored by its growing impact. Marine algae, characterized their unique bioactive compounds, have emerged as promising sources of novel anticancer agents in this context. This chapter reviews the potential marine algae treatment, emphasizing integration traditional knowledge modern scientific methods develop safe, affordable, accessible drugs. offer rich source including polysaccharides, polyphenols, pigments, known antioxidant, anti-inflammatory, antitumor effects. Moreover, these organisms evolved complex defense mechanisms, making them particularly interesting drug discovery. Research highlights multifaceted mechanisms apoptosis induction, cell cycle arrest, selective cytotoxicity against cells. Fucoxanthin, fucoidan, stigmasterol, other compounds from shown potent properties through modulation various signaling pathways. advantages include chemical diversity, sustainability, environmentally friendly cultivation, presenting exciting opportunities development. To address challenges herbal medicine, standardization, active compound identification, rigorous clinical trials are essential. Collaboration between practitioners scientists can bridge gap wisdom medical standards. Combinatorial therapies that integrate extracts conventional treatments more effective holistic management.

Language: Английский

Citations

1
Application of Antimicrobial Edible Film Incorporated with Caulerpa racemosa Crude Extract as Active Packaging of Seaweed Dodol DOI Creative Commons
Arham Rusli, Syamsuar Syamsuar,

Andi Santi

et al.

Applied Food Research, Journal Year: 2024, Volume and Issue: unknown, P. 100625 - 100625

Published: Nov. 1, 2024

Language: Английский

Citations

1
A randomized in vitro investigation on the modulation of the TGF-β signaling pathway and induction of apoptosis in colorectal cancer cells by green seaweed Caulerpa racemosa DOI Creative Commons
Happy Kurnia Permatasari,

Sarra Ben Bdira,

Myunghan Moon

et al.

Journal of Agriculture and Food Research, Journal Year: 2023, Volume and Issue: 14, P. 100796 - 100796

Published: Sept. 30, 2023

Colorectal cancer (CRC) poses a significant global health burden, necessitating innovative treatment strategies. This study evaluates the potential of Caulerpa racemosa extract, natural compound, to modulate transforming growth factor-beta (TGF-β) signaling pathway and induce apoptosis in CRC cells. HT-29 cells served as an vitro model. The were exposed n-hexane extract C. racemosa, TGF-β1 expression was assessed using immunofluorescence. Apoptosis quantified via annexin V propidium iodide staining through flow cytometry. significantly downregulated compared control group, suggesting its tumorigenesis progression inhibitor. displayed robust pro-apoptotic activity, with 800 μg/mL dose increasing early apoptotic 1200 dose. Other comparisons showed no differences, indicating optimal dosage range for induction at μg/mL. also induced notable increase necrotic/late control, triggering more potent response advanced stages. Our highlights TGF-β observed dose-dependent effects on late suggest applications preventive or therapeutic agent treatment. Further investigations are warranted explore extract's role combatting CRC's complex pathogenesis.

Language: Английский

Citations

2
Allelochemicals from the seaweeds and their bioprospecting potential DOI
Temjensangba Imchen, Supriya Tilvi, Keisham S. Singh

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(8), P. 5387 - 5401

Published: Feb. 23, 2024

Language: Английский

Citations

0
Blumea balsamifera and Sargassum aquifolium extracts reduce fatty liver damage through lipid metabolism signalling pathways DOI Creative Commons
I Gede Widhiantara, Putu Angga Wiradana, Anak Agung Ayu Putri Permatasari

et al.

INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY, Journal Year: 2024, Volume and Issue: 6(2), P. 131 - 142

Published: Oct. 30, 2024

Non-alcoholic fatty liver disease (NAFLD) is a condition marked by excessive fat accumulation in the and poses significant health challenge. The leaves of Blumea balsamifera Sargassum aquifolium have been reported to anti-atherogenic effects. This study aims determine effectiveness B. extract (BBLE) S. (SAE) preventing treating Wistar rats induced high-cholesterol diet through expression AMP-activated protein kinase (AMPK)/ Sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor γ (PPARγ) pathway, leptin receptor. experimental design this laboratory-based, involving, 20 were fed over period 21 days. divided into four groups for evaluation BBLE SAE effect: negative control (P0): with + distilled water, positive (P1): simvastatin, P2: 4 mg/kg/bw BBLE, P3: SAE. treatment duration extended three months. Immunohistochemical analyses performed on tissues measure AMPK, SIRT1, PPARγ, expression. results indicated that was lower BBLE+SAE group compared simvastatin group, differences between groups. No noted PPARγ (p≥0.05). In conclusion, effectively reduce lipid enhance metabolism hypercholesterolemic rats.

Language: Английский

Citations

0