The conundrum of the connection between severe psychiatric disorders and dementia

Dementia & Neuropsychologia, Journal Year: 2025, Volume and Issue: 19

Published: Jan. 1, 2025

ABSTRACT. Psychiatric disorders have been recognized as important risk factors for neurodegenerative diseases, especially dementia. The strength of association varies among different psychiatric conditions, being more pronounced in severe mental illnesses, i.e., schizophrenia and bipolar disorder. Multiple mechanisms seem to underlie this association, such high prevalence cardiovascular other physical morbidities, poor lifestyle choices, accelerated aging, including ‘inflammaging’. They all represent opportunities intervention, but it is still unclear whether current therapeutic approaches can prevent the development Other knowledge gaps include dementia applies patients with a certain condition, or if subgroups are vulnerable than others, types linked specific disorders.

Language: Английский

Sleep spindles as neurophysiological biomarkers of schizophrenia

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 59(8), P. 1907 - 1917

Published: Oct. 26, 2023

Schizophrenia (SCZ) is a complex psychiatric disorder characterized by wide range of clinical symptoms, including disrupted sleep. In recent years, there has been growing interest in assessing alterations sleep parameters patients with SCZ. Sleep spindles are brief (0.5-2 s) bursts 12- to 16-Hz rhythmic electroencephalogram (EEG) oscillatory activity occurring during non-rapid eye movement (NREM) Spindles have implicated several critical brain functions, learning, memory and plasticity, thought reflect the integrity underlying thalamocortical circuits. This review aims provide an overview current research investigating After briefly describing neurophysiological features spindles, I will discuss spindle characteristics observed SCZ, their associations symptomatology these putative neuronal molecular mechanisms. then utility measures as predictors treatment response disease progression. Finally, highlight future directions for this emerging field, prospect utilizing biomarkers

Language: Английский