Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156273 - 156273
Published: Dec. 1, 2024
Language: Английский
Clinical and Translational Allergy, Journal Year: 2025, Volume and Issue: 15(2)
Published: Feb. 1, 2025
Language: Английский
Citations
1
Allergy Asthma and Clinical Immunology, Journal Year: 2025, Volume and Issue: 20(S3)
Published: Jan. 22, 2025
Abstract Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions (HSRs) with varying mechanisms and clinical presentations. This type adverse drug reaction (ADR) not only affects patient quality life, but may also lead to delayed treatment, unnecessary investigations, increased morbidity mortality. Given the symptoms associated condition, diagnosis can be challenging. Therefore, referral an allergist experienced in management is recommended if drug-induced allergic suspected. Diagnosis relies on careful history physical examination and, some instances, skin testing or vitro challenges. The most effective strategy for allergist-confirmed avoidance discontinuation offending drug. When available, alternative medications unrelated chemical structures should substituted. Cross-reactivity among drugs taken into consideration when choosing agents. Additional therapy HSRs include topical corticosteroids, oral antihistamines severe cases, systemic corticosteroids other immunomodulators. In event anaphylaxis, treatment choice intramuscular epinephrine. If anaphylaxis requires specific there no acceptable alternative, desensitization that considered. article provides background strategies common reactions.
Language: Английский
Citations
0
Journal of Pain & Palliative Care Pharmacotherapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7
Published: Jan. 2, 2025
IgE-mediated opioid hypersensitivities, or true allergies, are rare and most adverse reactions to opioids can be attributed side effects pseudo-allergies. Given that immune-mediated allergies uncommon, literature regarding cross-reactivity among classes limited. This retrospective study aimed determine the rates of tolerance patients with previously documented allergy drug reaction (ADR) across three (natural, semisynthetic, synthetic opioids). Patients allergy(s) and/or ADR(s) were assessed for outcomes subsequent exposure during any hospital admission at a Veterans Affairs over 10-year time-period. sorted into cohorts based on class ADR. Each cohort had arms, one each exposure. A total 1507 identified ADR least No found resulting in 100% re-exposure all arms. These findings could increase confidence utilizing historically ADRs.
Language: Английский
Citations
0
Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 386 - 386
Published: Feb. 23, 2025
Background and Objectives: Early-type drug hypersensitivity reactions (DHRs) are observed within the first 1–6 h most commonly manifest as urticaria and/or angioedema. Detailed anamnesis, skin prick tests (SPTs), intradermal (IDTs), oral/intramuscular/intravenous provocation (DPTs) can be used to identify responsible. We aimed evaluate demographic characteristics, responsible drugs, DHR types, DPT results in diagnosis of allergy patients who presented our clinic with suspected allergies. Materials Methods: The medical records a suspicion an early-type between February 2019 December 2024 were retrospectively evaluated through hospital information management system. A total 188 adults underwent diagnostic testing included. Results: was confirmed 51 (27%) patients. In 137 (73%) patients, excluded after DPTs. 78 there single drug. other 110 had histories multiple drugs. rate confirmation from higher those described history Amongst antibiotics, beta-lactam antibiotics (n = 47) frequently positive DPTs 4; 8%) lower allergies than (p 0.002). NSAIDs 60) second common group With regard IgE or COX-1-mediated mechanisms, no statistically significant difference positivity among these 0.414). severity initial DHRs grade 1 168; 80%), 2 14; 7%), 3 7%). If redness, itching, urticaria, angioedema, dyspnea, cyanosis, desaturation, syncope, tachycardia, hypotension during their DHRs, test significantly higher. However, experiencing diarrhea, nausea, vomiting not found associated tests. Drug SPTs IDTs all whom adrenaline reactions. Conclusions: Contrary prevailing notion that drugs (especially beta-lactams) predominant cause allergic reactions, this study demonstrated actual prevalence is, fact, low.
Language: Английский
Citations
0
Published: April 3, 2025
Introduction. Medicinal urticaria is an immune-mediated disease characterized by the appearance of itchy rashes that occur in response to medication. The number reported cases drug allergies increasing every year, which makes study this topic particularly relevant. aim analyze characteristics medicinal patients Allergology and Immunology Department Mordovia Republic Central Clinical Hospital for period 2022–2024. Materials Methods. presents analysis 60 medical records diagnosed with urticarial Results. When analyzing structure patients, it was found women aged 31 59 years concomitant cardiovascular diseases lesions gastrointestinal tract are most often ill. advantage group antibiotics causally significant drugs urticaria, as well nonsteroidal anti-inflammatory drugs, angiotensin converting enzyme inhibitors sartans has been revealed. Discussion Conclusion. materials article can be useful formulating recommendations safe prescription medications raising awareness among professionals about possible allergic reactions. This, turn, will help prevent occurrence improve quality life patients.
Language: Английский
Citations
0
International Journal of Hygiene and Environmental Health, Journal Year: 2025, Volume and Issue: 266, P. 114574 - 114574
Published: April 10, 2025
Language: Английский
Citations
0
Frontiers in Allergy, Journal Year: 2024, Volume and Issue: 5
Published: Nov. 12, 2024
Introduction The clinical significance of elevated baseline serum tryptase (BST) in the absence mast cell disorders or allergic reactions has long been unclear. Recently, a genetic variation TPSAB1 gene, which among others encodes for alpha tryptase, reported and named hereditary tryptasemia (HaT). HaT linked to various manifestations, including severe reactions. However, studies are limited. In this study, we aimed determine prevalence characterize its manifestations patients at specialized allergy center. Methods From January 2022 December 2023, with BST least once were screened outpatient clinic. A control group included history anaphylaxis undergoing specific Hymenoptera immunotherapy. copy numbers, levels, parameters assessed analyzed. Results Of 47 (≥11.4 µg/L), 93% showed increased numbers. Individuals diagnosed displayed range between 12.3 28.4 µg/L, 84.1% associated duplication 15.9% triplication. predominated women (86.4%) was thyroid disease (27.3%). Over half had (54.5%), mainly low-grade. Discussion but no mastocytosis, most likely cause an increase number gene. heightened risk should be considered. Further research is needed explore predominance emerging link disease.
Language: Английский
Citations
0
Immunologic Research, Journal Year: 2024, Volume and Issue: 72(5), P. 1071 - 1085
Published: July 29, 2024
Language: Английский
Citations
0
The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
0
The Journal of Allergy and Clinical Immunology In Practice, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
0