Penicillin allergy delabeling in long-term care facilities: if not now, then when?

Antimicrobial Stewardship & Healthcare Epidemiology, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 1, 2025

Language: Английский

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Penicillin allergy management strategies relevant for clinical practice - a narrative review

Romanian Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Abstract Penicillin allergy is the most commonly reported drug allergy, with prevalence rates ranging from 6% to 31% across various populations and geographic areas. The penicillin label linked higher mortality morbidity rates, extended hospital stays, increased readmission a greater reliance on second-line antibiotics. Research indicates that nearly 99% of those labeled as penicillin-allergic can tolerate drug. However, alternative antibiotics are often prescribed without confirming largely due legal concerns regarding re-exposure. Even when negative challenge test conducted, non-allergist providers may remain hesitant reintroduce penicillin. To address considerable gap between actual allergies, well ensure prompt use penicillins by non-allergists, management strategies have emerged in recent years. Although several comprehensive reviews examined these strategies, selecting applying suitable for routine practice difficult. This narrative review focuses relevant data efficiency key risk assessment tools, particularly clinical significance, discusses their readiness implementation settings.

Language: Английский

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Association between penicillin allergy labels and serious adverse events in hospitalized patients: a systematic review and meta-analysis

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

To date, several studies have demonstrated that erroneous labeling of Penicillin allergy (PAL) can significantly impact treatment options and result in adverse clinical outcomes, while other reported no negative effects. Therefore, to systematically evaluate these effects investigate the association between outcomes label, we conducted this meta-analysis. Searches were PubMed, Embase, Cochrane Library, Web Science databases from inception 13 July 2024. The search strategy utilized terms ("antibiotic label," "penicillin "allergy label") ("death," "readmission," "adverse outcome," "clinical outcome"). In study selection process, PICOS framework stringent inclusion/exclusion criteria applied. quality initially included was independently assessed using Newcastle-Ottawa Scale (NOS). Data studies, including relative risk (RR) 95% confidence intervals (CI), extracted analyzed Stata 16.0. Sensitivity analyses validate results. Heterogeneity I2 Q tests, publication bias evaluated Egger's test funnel plot analysis. A total 497 relevant identified through four databases. Following a thorough screening 11 encompassing 1,200,785 participants ultimately included. combined evidence suggests penicillin is associated with increased mortality RR = 1.06 (95% CI 1.06-1.07, 0.00%), acute heart failure (RR 1.19, 1.09-1.30, τ2 0.00, 92.39%), ICU events 1.10, 1.01-1.19, 57.09%), mechanical ventilation 1.16, 1.09-1.24, 23.11%). Additionally, there significant readmissions 1.05, 0.95-1.16, 0.00%). Our findings indicate labels are an patients, as well being linked failure, heightened requirements, ventilation. PROSPERO, identifier CRD42024571535. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD4202457153.

Language: Английский

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Spotlight commentary: De‐labelling the truth: Clearing the fog around antibiotic allergy labels

British Journal of Clinical Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Language: Английский

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A systematic review and meta‐analysis of interventions to delabel low‐risk penicillin allergies with consideration for sex and gender

British Journal of Clinical Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 19, 2024

Sex and gender may influence penicillin allergy label (PAL) prevalence outcomes. This review evaluates the effectiveness safety of direct delabelling (DD) oral challenge (OC) for low-risk patients examines sex differences in reporting

Language: Английский

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