EUFOREA meeting on defining disease states in allergic rhinitis: towards a unified language in AR

Frontiers in Allergy, Journal Year: 2025, Volume and Issue: 5

Published: Feb. 3, 2025

Allergic rhinitis (AR), the most prevalent immunological disease, affects approximately 400 million individuals globally and can significantly impact quality of life (QoL). Despite nearly 25 years guidelines, AR remains largely under- diagnosed, suboptimally treated poorly controlled. In light new knowledge treatment options, there is a necessity to update or revise fundamental definitions facilitate communication across diverse specialties engaged in its improve patient care. The European Forum for Research Education Allergy Airway Diseases (EUFOREA) convened meeting experts representatives deliberate optimal methodology measuring responses establishing novel goals. This paper presents consensus on revised definitions, including control, severe allergic rhinoconjunctivitis (SARC), refractory (R-SARC), remission, resolution, improvement, exacerbation, treatable traits (TTs), treat target, relapse, progression, disease modification, prevention.

Language: Английский

Impact of allergic symptoms on work productivity in allergic rhinitis: A MASK-air direct patient data study

Allergology International, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Allergic rhinitis may impair work productivity. This study aimed to assess (i) the differential impact of allergic symptoms on performance, assessed by means Visual Analogue Scale (VAS) work; and (ii) effect asthma comorbidity We data from MASK-air mHealth app patients with rhinitis. identified factors associated productivity through multivariable linear mixed effects models. studied 260,378 days 20,724 patients. In regression models, nasal showed strongest association VAS (regression coefficient = 0.38 [95%CI 0.38; 0.38]). Poor control, measured combined symptom-medication score, was worse 0.96 0.96; 0.97]). The median in probable or possible (median 9, interquartile range 22 for 23 asthma) greater than no evidence 3, 12) (Cohen's d 0.60). asthma, a similar nose 0.32 0.31; 0.32]; 0.30 0.29; 0.31]). Allergy symptoms, especially are addition, display more impairment alone.

Language: Английский

Innovative surgical approaches for chronic rhinitis: nasal neurectomy mechanisms, techniques, and clinical outcomes

Expert Review of Clinical Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Chronic rhinitis (CR) represents a prevalent, persistent inflammatory condition of the nasal mucosa, substantially impacting patients' quality life. Despite standard pharmacotherapy, many patients with refractory symptoms do not achieve adequate relief, highlighting need for alternative interventions such as neurectomy. Literature was reviewed on PubMed, EMBASE, and Web Science databases published from March 1961 to April 2025. Our review discusses underlying mechanisms, surgical techniques, clinical outcomes different neurectomy approaches, including vidian neurectomy, vidian-branch anterior ethmoidal well recent advancements in endoscopic minimally invasive methods. Nasal presents promising managing CR by directly targeting neuro-immune pathways that drive symptoms. Understanding will only advance our insight into pathophysiology but also guide development refined, patient-specific strategies optimal outcomes.

Language: Английский