Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(6), P. 441 - 441
Published: March 14, 2025
A
stabilized
biochar
(BC)–nano-scale
zero-valent
iron
(nZVI)
composite
(BC-nZVI@Cell-g-PAA)
was
prepared
using
cellulose-grafted
polyacrylic
acid
(Cell-g-PAA)
as
the
raw
material
through
in
situ
polymerization
and
liquid-phase
reduction
methods
for
remediation
of
hexavalent
chromium
(Cr(VI))-contaminated
water.
BC-nZVI@Cell-g-PAA
characterized
by
XRD,
FT-IR,
SEM,
BET,
TEM,
XPS.
According
to
batch
experiments,
under
optimized
conditions
(Cr(VI)
concentration
50
mg/L,
pH
=
3,
dosage
2
g/L),
achieved
maximum
Cr(VI)
removal
efficiency
(99.69%)
within
120
min.
Notably,
BC,
a
carrier,
high
dispersion
nZVI
its
porous
structure,
effectively
preventing
particle
agglomeration
improving
reaction
activity.
Simultaneously,
functional
groups
on
surface
Cell-g-PAA
provided
excellent
protection
nZVI,
significantly
suppressing
oxidative
deactivation.
Furthermore,
reduced
insoluble
trivalent
chromium(Cr(III))
species
them
immobilization.
The
synergistic
effects
physical
adsorption
chemical
greatly
contributed
Cr(VI).
Remarkably,
exhibited
reusability
with
62.4%
after
five
cycles,
demonstrating
potential
promising
remediating
Cr(VI)-contaminated
In
conclusion,
not
only
demonstrated
remarkable
but
also
showcased
practical
applications
environmental
remediation,
evidenced
sustained
performance
over
multiple
reuse
cycles.
Moreover,
Cr(VI),
toxic
carcinogenic
substance,
poses
significant
risks
aquatic
ecosystems
human
health,
underscoring
importance
developing
effective
from
contaminated
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 11, 2024
Radiation-induced
lung
injury
(RILI)
is
a
prevalent
complication
of
thoracic
tumor
radiotherapy
and
accidental
radiation
exposure.
Pyrroloquinoline
quinone
(PQQ),
novel
vitamin
B,
plays
crucial
role
in
delaying
aging,
antioxidation,
anti-inflammation,
antiapoptosis.
This
study
aims
to
investigate
the
protective
effect
mechanisms
PQQ
against
RILI.
C57BL/6
mice
were
exposed
20
Gy
dose
X-ray
on
entire
thorax
with
or
without
daily
oral
administration
for
2
weeks.
effectively
mitigated
radiation-induced
tissue
damage,
inflammation,
oxidative
stress,
epithelial
cell
apoptosis.
Additionally,
significantly
inhibited
stress
mitochondrial
damage
MLE-12
cells.
Mechanistically,
upregulated
mRNA
protein
levels
MOTS-c
irradiated
Knockdown
by
siRNA
substantially
attenuated
effects
In
conclusion,
alleviates
RILI
preserving
function
through
MOTS-c-dependent
mechanism,
suggesting
that
may
serve
as
promising
nutraceutical
intervention
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2025,
Volume and Issue:
39(3)
Published: Feb. 25, 2025
ABSTRACT
Cyclophosphamide
(CYP)
is
an
effective
chemotherapeutic
and
immunosuppressive
agent;
however,
its
clinical
application
limited
by
a
variety
of
toxic
side
effects.
Mitochondrial
dysfunction
has
been
associated
with
the
pathogenesis
chemotherapy‐induced
cardiotoxicity.
This
work
aimed
to
evaluate
possible
protective
effect
galangin
(Gal)
on
CYP‐induced
cardiotoxicity,
pointing
ability
promote
mitochondrial
biogenesis.
Thirty
two
male
rats
were
allocated
equally
into
four
groups:
control;
Gal‐treated;
CYP‐treated;
Gal
+
CYP‐treated
groups.
Markers
cardiac
injury,
oxidative/antioxidant
status,
inflammation,
apoptosis,
function
assessed
in
addition
histopathological
electrocardiographic
(ECG)
evaluation.
The
current
results
revealed
that
treatment
significantly
attenuated
injury
retrieved
alterations
histopathology
ECG
changes.
Also,
it
restored
redox
balance,
as
evidenced
alleviation
malondialdehyde
(MDA)
levels
increased
glutathione
peroxidase
(GPx)
activity.
activated
sirtuin
(SIRT)
1/nuclear
factor
erythroid
2‐related
2
(Nrf2)‐mediated
signaling
pathway,
indicated
upregulation
SIRT1,
Nrf2,
SIRT3,
transcription
(TFAM),
superoxide
dismutase
(SOD)2
peroxisome
proliferator‐activated
receptor
gamma
coactivator
1‐alpha
(PGC‐1α),
together
activity
citrate
synthase
(CS),
improved
function.
It
ameliorated
inflammation
apoptosis‐associated
markers
supported
biochemical
immunostaining
data.
Our
study
provided
novel
insights
elucidating
mitigative
potential
against
oxidative
damage,
upregulating
SIRT1/Nrf2/SIRT3/PGC‐1α/TFAM
survival
pathway.
Nanomaterials,
Journal Year:
2025,
Volume and Issue:
15(6), P. 441 - 441
Published: March 14, 2025
A
stabilized
biochar
(BC)–nano-scale
zero-valent
iron
(nZVI)
composite
(BC-nZVI@Cell-g-PAA)
was
prepared
using
cellulose-grafted
polyacrylic
acid
(Cell-g-PAA)
as
the
raw
material
through
in
situ
polymerization
and
liquid-phase
reduction
methods
for
remediation
of
hexavalent
chromium
(Cr(VI))-contaminated
water.
BC-nZVI@Cell-g-PAA
characterized
by
XRD,
FT-IR,
SEM,
BET,
TEM,
XPS.
According
to
batch
experiments,
under
optimized
conditions
(Cr(VI)
concentration
50
mg/L,
pH
=
3,
dosage
2
g/L),
achieved
maximum
Cr(VI)
removal
efficiency
(99.69%)
within
120
min.
Notably,
BC,
a
carrier,
high
dispersion
nZVI
its
porous
structure,
effectively
preventing
particle
agglomeration
improving
reaction
activity.
Simultaneously,
functional
groups
on
surface
Cell-g-PAA
provided
excellent
protection
nZVI,
significantly
suppressing
oxidative
deactivation.
Furthermore,
reduced
insoluble
trivalent
chromium(Cr(III))
species
them
immobilization.
The
synergistic
effects
physical
adsorption
chemical
greatly
contributed
Cr(VI).
Remarkably,
exhibited
reusability
with
62.4%
after
five
cycles,
demonstrating
potential
promising
remediating
Cr(VI)-contaminated
In
conclusion,
not
only
demonstrated
remarkable
but
also
showcased
practical
applications
environmental
remediation,
evidenced
sustained
performance
over
multiple
reuse
cycles.
Moreover,
Cr(VI),
toxic
carcinogenic
substance,
poses
significant
risks
aquatic
ecosystems
human
health,
underscoring
importance
developing
effective
from
contaminated
