Differential effects of high-fat diet on salivary and gut microbiota DOI Creative Commons
Bai Jian, Yunbo Tian, Yujia Lu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 24, 2025

Microorganisms contribute to the pathogenesis of obesity, while more studies focus on gut microbiome. However, relationship between oral microbiota and obesity has yet be elucidated. This study was designed investigate similarities differences in effects a high-fat diet salivary through mouse experiments, exploring hypothesis that microbial mechanisms may obesity. An obese model established male C57BL/6J mice by feeding diet, confirmed body weight records blood glucose tests. evaluated physiological mice. 16S rRNA sequencing technology used analyze changes microbiota, gas chromatography-mass spectrometry employed evaluate 17 short-chain medium-chain fatty acids quantitatively. The distribution different (HFD) normal chow (NCD) groups. At genus level Streptococcus Escherichia were highly abundant HFD group. Rodentibacter Turicibacter NCD Regarding microbiome, diversity are significant than those microbiota. group had significantly higher abundance Kineothrix, Cryptobacteroides, lower CAG-485. Nine genera consistent alterations among which Akkermansia, Lactobacillus, Intestinimonas correlated with indicators, Muribaculum increased decanoic acid levels dysregulated nine associated upregulation certain metabolic pathways group, including pentose phosphate, bacterial invasion epithelial cells, steroid biosynthesis pathways. There Certain oral-gut axis altered consistently affect involving inflammation.

Language: Английский

Aggregation-induced emission: recent applications in infectious diseases DOI
Meijia Gu,

Luojia Chen,

Rui Hu

et al.

Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(11), P. 2986 - 3005

Published: Oct. 24, 2023

Language: Английский

Citations

17
Oral microbiota–host interaction: the chief culprit of alveolar bone resorption DOI Creative Commons
Jingyu Xu, Ling Yu,

Surong Ye

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

There exists a bidirectional relationship between oral health and general well-being, with an imbalance in symbiotic flora posing threat to overall human health. Disruptions the commensal can lead diseases, while systemic illnesses also impact cavity, resulting development of diseases disorders. Porphyromonas gingivalis Fusobacterium nucleatum , known as pathogenic bacteria associated periodontitis, play crucial role linking periodontitis accompanying diseases. In periodontal tissues, these bacteria, along their virulence factors, excessively activate host immune system through local diffusion, lymphatic circulation, blood transmission. This response disruption contributes osteoimmune mechanisms, alveolar bone resorption, potential inflammation. To restore homeostasis, deeper understanding microbiota–host interactions network phenotype tissues is imperative. Defining offers promising avenue for investigating complex characteristics plaque biofilms exploring review aims provide overview mechanisms underlying - -induced well immunophenotypes observed during pathological conditions.

Language: Английский

Citations

6
Diet and high altitude strongly drive convergent adaptation of gut microbiota in wild macaques, humans, and dogs to high altitude environments DOI Creative Commons
Junsong Zhao, Yongfang Yao,

Mengmeng Dong

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 23, 2023

Animal gut microbiota plays an indispensable role in host adaptation to different altitude environments. At present, little is known about the mechanism of animal high Here, we selected wild macaques, humans, and dogs with levels kinship intimate relationships low environments, analyzed response their diet Alpha diversity analysis found that at altitude, macaques more complex environments much higher than humans simpler (p < 0.05), beta UniFrac distance between was significantly lower indicating strongly drive convergence among species. Meanwhile, alpha three subjects, population (ACE index species, Shannon dog macaque Simpson dog, p distances subjects were 0.05). Additionally, core shared ASVs number up 5.34 times (1,105/207), proportion relative abundance bacteria types each species The results showed played important driving Furthermore, neutral community model trial dispersed implying animals altitudes may be partly due microbial transmission hosts mediated by human activities.

Language: Английский

Citations

14
Cytokine and microbiota profiles in obesity-related hypertension patients DOI Creative Commons
Marı́a Magdalena Aguirre-Garcı́a, Amedeo Amedei, Paulina Hernández-Ruiz

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 13

Published: Jan. 16, 2024

Background Systemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on global scale. In Mexico, nearly half adults in vulnerable conditions experience hypertension. Imbalance the oral and intestinal microbiota composition has been observed patients with hypertension, documented by decrease bacteria producing short-chain fatty acids, which play critical role blood pressure regulation. Aim To examine cytokines’ profile assess characteristics gut obesity-related Mexican patients. Methods A cross-sectional, observational, analytical study was carried out. Twenty-two were categorized their body mass index (BMI) as overweight obese, diagnosis primary DNA from supragingival dental plaque feces samples used carry out 16S rRNA sequencing. Additionally, 13 cytokines quantified. Results microbiota, Kluyvera found be significantly enriched obese compared Instead, dominated Firmicutes. However, correlation between certain genera proinflammatory noted. Conclusion This exploratory provides insights into complex relationship association systemic inflammation

Language: Английский

Citations

5
Effects of bacterial extracellular vesicles derived from oral and gastrointestinal pathogens on systemic diseases DOI
Han Zhang,

Y. Lin,

Siwei Li

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 285, P. 127788 - 127788

Published: June 1, 2024

Language: Английский

Citations

5
Oral Microbiome Dysbiosis as a Risk Factor for Stroke: A Comprehensive Review DOI Creative Commons
Georgy Leonov, Diana Salikhova, Antonina V. Starodubova

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1732 - 1732

Published: Aug. 22, 2024

Stroke represents a significant global health burden, with substantial impact on mortality, morbidity, and long-term disability. The examination of stroke biomarkers, particularly the oral microbiome, offers promising avenue for advancing our understanding factors that contribute to risk developing strategies mitigate risk. This review highlights correlations between diseases, such as periodontitis caries, onset stroke. Periodontal pathogens within microbiome have been identified contributing factor in exacerbation stroke, including obesity, dyslipidemia, atherosclerosis, hypertension, endothelial dysfunction. alteration may these conditions, emphasizing vital role prevention cardiovascular disease. integration dental medical practices enhancing efforts improving patient outcomes.

Language: Английский

Citations

5
Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension DOI Creative Commons
Bo‐Yan Chen, Wen-Zhen Lin, Yulin Li

et al.

Microbiology Spectrum, Journal Year: 2022, Volume and Issue: 11(1)

Published: Dec. 8, 2022

The mycobiome is an essential constituent of the human microbiome and associated with various diseases. However, role oral gut fungi in hypertension (HTN) remains largely unexplored. In this study, saliva, subgingival plaques, feces were collected from 36 participants HTN 24 healthy controls for metagenomic sequencing. obtained sequences analyzed using Kraken2 taxonomic annotation pipeline to assess fungal composition diversity. Correlations between clinic parameters, within same sample types, different types identified by Spearman's correlation analysis. Overall, had substantially higher alpha diversity than salivary fecal microbiomes. microbiomes three displayed distinct beta each other. Oral but not significantly that controls. Among shared cavity gut, Exophiala was genus most notable changes. spinifera abundant species HTN. Some directly correlated blood pressure, including xenobiotica mesophila. markedly impaired ecological cocorrelation networks suggested compromised association among species. Most their correlations potential interplays fungi. conclusion, intestine have unique environments. enrichment ecology HTN, fungi, associations clinical parameters suggest important may play IMPORTANCE Our study fills gap studies investigating microbiota pressure. It characterizes subjects, elucidates dysbiosis a hypertensive population, establishes oral-gut fungus-clinical parameter correlations. Targeting and/or provide novel strategies prevention treatment hypertension.

Language: Английский

Citations

18
Salivary microbiome and hypertension in the Qatari population DOI Creative Commons
Selvasankar Murugesan, Souhaila Al Khodor

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: July 8, 2023

The prevalence of hypertension in Qatar is 33 percent the adult population. It postulated that salivary microbiome can regulate blood pressure (BP). However, limited investigations exist to prove this hypothesis. Therefore, we examined difference composition between hypertensive and normotensive Qatari subjects.A total 1190 Genome Project (QGP) participants (Mean age = 43 years) were included study. BP for all was classified into Normal (n 357), Stage1 336), Stage2: 161) according American Heart Association guidelines. 16S-rRNA libraries sequenced analyzed using QIIME-pipeline, PICRUST used predict functional metabolic routes. Machine Learning (ML) strategies applied identify microbiome-based predictors hypertension.Differential abundant analysis (DAA) revealed Bacteroides Atopobium significant members groups. Alpha beta diversity indices indicated dysbiosis ML-based prediction models these markers could with an AUC (Area under curve) 0.89. Functional predictive disclosed Cysteine Methionine metabolism sulphur pathways involving renin-angiotensin system significantly higher group. serve as hypertension. Likewise, Prevotella, Neisseria, Haemophilus be protectors via nitric acid synthesis regulation system.It one first studies assess disease a large cohort Further research needed confirm findings validate mechanisms involved.

Language: Английский

Citations

10
The Interplay of Edentulism, Smoking, Microbiota, Oral Rehabilitation on CytokineProfile and Different Conditions of Hypertension DOI
Pillar Gonçalves Pizziolo, Lorena Mosconi Clemente, Aline Barbosa Ribeiro

et al.

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: 172, P. 106176 - 106176

Published: Jan. 11, 2025

Language: Английский

Citations

0
Metformin as an immunomodulatory agent in enhancing head and neck squamous cell carcinoma therapies DOI
Wenting Li, Naiming Liu, Mingwei Chen

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189262 - 189262

Published: Jan. 17, 2025

Language: Английский

Citations

0