A clinical-radiomics combined model based on carotid atherosclerotic plaque for prediction of ischemic stroke DOI Creative Commons
Na Han,

Wanjun Hu,

Yurong Ma

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: March 13, 2024

Objectives To accurately predict the risk of ischemic stroke, we established a radiomics model carotid atherosclerotic plaque-based high-resolution vessel wall magnetic resonance imaging (HR-VWMRI) and combined it with clinical indicators. Materials methods In total, 127 patients were finally enrolled randomly divided into training test cohorts. HR-VWMRI three-dimensional T1-weighted (T1WI) contrast-enhanced T1WI (T1CE) collected. A traditional was built by recording calculating radiographic features plaques patients’ After extracting from T1CE images, least absolute shrinkage selection operator (LASSO) algorithm used to select optimal construct radiomics_T1WI radiomics_T1CE model. The build models. performance all models predicting stroke evaluated in cohorts, respectively. Results Body mass index (BMI) intraplaque hemorrhage (IPH) independently related model, which achieved an area under curve (AUC) 0.79 versus 0.78 AUC value is lowest but prediction significantly improved when combines IPH BMI. combined_T1WI 0.81 addition, based on characteristics, combined_T1CE had highest 0.84 0.82, Conclusion Compared other models, can stroke.

Language: Английский

Association between C-reactive protein-triglyceride glucose index and testosterone levels among adult men: analyses of NHANES 2015–2016 data DOI Creative Commons
Bo Zhang, Yi Gu, Yiming Chen

et al.

Sexual Medicine, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 1, 2025

Language: Английский

Citations

0
Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 DOI Creative Commons
Wei Wang, Shuai Zhao,

Ran Zhou

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 18, 2025

Erectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health men their partners. Metabolic syndrome (MetS) most important public problem threatening men's worldwide, its current prevalence continues to grow. This study examines relationship between metabolic erectile (ED). We conducted cross-sectional with data were sourced from NHANES 2001-2004. In this study, METS-VF ED was analyzed using multivariate logistic regression, followed by subgroup analyses identify sensitive populations. Comparative regression Receiver Operating Characteristic (ROC) curve assessed diagnostic capability against classical obesity index for ED. Creating Predictive Histograms Patients assess net benefit model through Decision Curve Analysis (DCA). The enrolled 1,374 participants, whom 545 self-reported history. There significant positive association risk in people 2.32 times higher than without (dominance ratio = 2.32, 95% confidence interval: 1.83-2.96, p < 0.001). Subgroup analysis highlighted stronger correlation participants aged 50-85 years, hypertensive individuals, those large belly circumference. A histogram including three variables: syndrome, age smoking status constructed predict probability occurrence. And decision (DCA) used nomogram at different high-risk thresholds. high utility under thresholds illustrated. syndrome. Furthermore, observed emphasizes need increased vigilance patients advanced age, smoking, MetS.

Language: Английский

Citations

0
Identification and Experimental Validation of NETosis-Mediated Abdominal Aortic Aneurysm Gene Signature Using Multi-omics, Machine Learning, and Mendelian Randomization DOI

Chengsong Wu,

Yuanyuan Ren, Li Yang

et al.

Journal of Chemical Information and Modeling, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Abdominal aortic aneurysm (AAA) is a life-threatening disorder with limited therapeutic options. Neutrophil extracellular traps (NETs) are formed by process known as "NETosis" that has been implicated in AAA pathogenesis, yet the roles and prognostic significance of NET-related genes remain poorly understood. This study aimed to identify key AAA- (AAA-NETs-RGs), elucidate their potential mechanisms contributing AAA, explore compounds for therapy. Through bioinformatics analysis multiomics machine learning, we identified six AAA-NETs-RGs: DUSP26, FCN1, MTHFD2, GPRC5C, SEMA4A, CCR7, which exhibited strong diagnostic predicting progression, were significantly enriched pathways related cytokine-cytokine receptor interaction chemokine signaling. Immune infiltration revealed causal association between AAA-NETs-RGs immune cell infiltration. Cell-cell communication indicated predominantly function smooth muscle cells, B T NK primarily through cytokine Gene profiling CCR7 MTHFD2 most significant upregulation patients compared non-AAA controls, well vitro models. Notably, genetic depletion strongly inhibited Ang II-induced phenotypic switching, functional impairment, senescence vascular cells (VSMCs). Based on AAA-NETs-RGs, molecular docking combined Connectivity Map (CMap) database mirdametinib agent AAA. Mirdametinib effectively alleviated biological dysfunction, senescence. These findings provide valuable insights into understanding pathophysiology highlight promising strategies targeting AAA-NETs-RGs.

Language: Английский

Citations

0
Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate DOI Creative Commons
Jack Ng, C. Mary Schooling

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 24, 2025

Language: Английский

Citations

0
Effects and Moderators of Exercise Training on Erectile function in Male Adults with diagnosed erectile dysfunction: A Systematic Review and Meta-Analysis DOI

Haiyang Sun,

Yan Zhao, Xinyue Liao

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Background Erectile dysfunction (ED) is widespread among adult men and affects their quality of life psychological health. There increasing evidence that physical exercise sports training can effectively improve erectile function, but the effects these interventions influencing factors require further systematic analysis. Objectives To evaluate intervention effect on in through a review meta-analysis. Second, to explore moderating different modes, intensity, other effect. Methods Electronic searches were conducted Embase, Cochrane Central, Scopus, Ovid MEDLINE, PubMed, Web Science, China National Knowledge Infrastructure (CNKI) up October 2024. Randomized controlled trials (RCTs) involving with precise diagnosis (IIEF-5 scores <21) included investigate function (EF). The bias risk studies was assessed using Risk Bias tool 2.0 (Rob2). In addition, subgroup analyses performed identify relative advantages each method improving function. Results 12 randomized 818 results demonstrated significantly improved by 2.9 points (95% CI 1.7–4.1, p < 0.001). Sub-group types showed most considerable significant observed for aerobic combined pharmacological treatment (MD = 3.04, 95% 1.15 4.92, 0.002) traditional Asian 4.28, 2.95 5.61, Other show consistent age or medical condition groups tendency have more low-intensity than moderate- high-intensity exercise. Conclusions Interventions including men, analysis indicating combining treatments yields greatest benefits. PROSPERO Registration CRD42024593228.

Language: Английский

Citations

0
Review of Mendelian randomization studies on common male-specific diseases DOI Creative Commons
Qingsong Pang, Zhe Chang, Haibo Liu

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant literature PubMed and the Web Science published before May 2024; systematically summarized progress application infertility, erectile dysfunction, prostate cancer, prostatitis; classified affecting men’s health, such as gut microbiota, modifiable related diseases; presented some problems solutions that were studies. information offers valuable insights into etiology pathogenesis male-specific diseases.

Language: Английский

Citations

0
The impact of cannabis use on erectile dysfunction and sex hormones: a Mendelian randomization analysis DOI
Youqian Zhang, Yue Su, Zitian Tang

et al.

International Journal of Impotence Research, Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Language: Английский

Citations

3
Possible sarcopenia and risk of chronic kidney disease: a four-year follow-up study and Mendelian randomization analysis DOI
Yang Xiong, Xue Jiang, Qian Zhong

et al.

Endocrine Research, Journal Year: 2024, Volume and Issue: 49(3), P. 165 - 178

Published: May 13, 2024

Chronic kidney disease (CKD) is a common risk factor for sarcopenia. However, whether sarcopenia increases the of CKD remains unclear. To investigate longitudinal and causal associations between possible CKD, this study was performed.

Language: Английский

Citations

2
A Mitochondrion‐Targeting Piezoelectric Nanosystem for the Treatment of Erectile Dysfunction via Autophagy Regulation DOI Open Access
Shuting Wang, Zhenqing Wang,

Zhenjie Zang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Mitochondrial damage caused by external stimuli, such as high glucose levels and inflammation, results in excessive reactive oxygen species (ROS) production. Existing antioxidants can only scavenge ROS cannot address the root cause of production, namely, abnormal mitochondria. To overcome this limitation, study develops a piezoelectric synergistic drug-loaded nanosystem (BaTCG nanosystem) that targets The BaTCG is delivered to mitochondria via triphenylphosphine modification, generates current under stimulation ultrasound, thereby promoting mitochondrial autophagy restoring homeostasis. In model diabetes-related erectile dysfunction (ED), nanosystem, through induced effect, not promoted mitophagy, reducing but also released long-acting glucagon-like peptide-1 receptor agonists (GLP-1RAs) effectively reduce blood damage. Each component functions individually well synergistically, thus facilitating corpus cavernosum repair function. conclusion, findings offer novel therapeutic strategy for ED target treatment conditions with functionalized nanoparticles regulate mitophagy.

Language: Английский

Citations

2
The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study DOI Creative Commons
Jingxuan Peng,

Jinshun An,

Yuxing Chen

et al.

Sexual Medicine, Journal Year: 2024, Volume and Issue: 12(6)

Published: Dec. 1, 2024

Language: Английский

Citations

2