Biophysical characterization and in silico analysis of natural and synthetic compounds targeting Listeria monocytogenes HtrA protease DOI

M C Amrutha,

Silja Weßler, Karthe Ponnuraj

et al.

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Language: Английский

Recent advances in self-targeting natural product-based nanomedicines DOI Creative Commons

Haifan Liu,

Xingyue Jin, Suyi Liu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 20, 2025

Language: Английский

Citations

7
Therapeutic Perspectives of Aminoflavonoids—A Review DOI Open Access
Monika Stompor, Agata Bajek-Bil, Natalia Potocka

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2014 - 2014

Published: Feb. 25, 2025

Natural compounds containing nitrogen are a source of many biologically active molecules used as drugs. Due to their multidirectional effects, they represent effective therapeutic in medical areas. Flavonoids, well bioprecursors, chalcones, that occur plants possess number medicinal benefits. Their synthetic amino derivatives constitute large group exhibit pharmacological activity. the increasing level drug resistance among patients, new agents and options urgently needed. Therefore, aminoflavonoids may be promising In this review, biological activities flavonoids, including with complexes atom aminoflavones Ru Pt summarized. The purpose review is provide an overview synthesis activity show how modifications these can influence activities. It covers most recent reports on obtaining aminoflavones, aminochalcones, derivatives, along information about anticancer, antimicrobial, antimalarial, antiviral, anti-inflammatory

Language: Английский

Citations

1
Altechromone A Ameliorates Inflammatory Bowel Disease by Inhibiting NF-κB and NLRP3 Pathways DOI Creative Commons
Lei Li, Jing Huang,

Lixin Feng

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(9), P. 410 - 410

Published: Sept. 9, 2024

Altechromone A, also known as 2,5-dimethyl-7-hydroxychromone, is a hydroxyketone containing one hydroxyl and ketone group. In this study, we isolated A from the marine-derived fungus

Language: Английский

Citations

4
National-scale 1-km maps of hospital travel time and hospital accessibility in China DOI Creative Commons

Pei Ye,

Z.Q. Ye,

Jizhe Xia

et al.

Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)

Published: Oct. 15, 2024

Ensuring equitable access to health services is crucial for public welfare and social equity, a key objective of the United Nations' Sustainable Development Goals (SDGs). However, existing datasets often define hospital accessibility using travel time hospitals in geographic dimension only, without considering supply (hospital capacity) demand (population distribution) dynamics. To overcome this limitation, we developed validated national-scale 1 km map both China. We used Gaussian two-step floating catchment area (Ga2SFCA) model calculate accessibility, incorporating capacity service population. Various file types statistical indicators are provided, making dataset highly accessible non-specialists. The fills gap publicly available nationwide data China can serve as critical tool optimizing resource allocation developing targeted strategies improve healthcare equity.

Language: Английский

Citations

4
Betulin inhibits the production of inflammatory cytokines in human gingival fibroblasts and ligature-induced periodontitis DOI
Ya‐Hsin Wu, Fidel Ramírez,

Yen-You Lin

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 147, P. 114018 - 114018

Published: Jan. 6, 2025

Language: Английский

Citations

0
Mechanistic Insights into the Anticancer Potential of Methoxyflavones Analogs: A Review DOI Creative Commons

Mohammad Aidiel,

Maisarah Abdul Mutalib, Rajesh Ramasamy

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 346 - 346

Published: Jan. 16, 2025

2-phenylchromen-4-one, commonly known as flavone, plays multifaceted roles in biological response that can be abundantly present natural sources. The methoxy group naturally occurring flavones promotes cytotoxic activity various cancer cell lines by targeting protein markers, facilitating ligand-protein binding mechanisms and activating cascading downstream signaling pathways leading to death. However, the lipophilic nature of these analogs is a key concern it impacts drug membrane transfer. While lipophilicity crucial for efficacy, excessive effects flavonoids reduce water solubility hinder transport target sites. Recent vitro studies suggest incorporation polar hydroxyl groups which form hydrogen bonds stabilize free radicals may help overcome challenges associated with while maintaining their essential properties. Naturally coexisting methoxyflavones, this review explores synergistic role hydroxy moieties through bonding capacity maximizing cytotoxicity against lines. physicochemical analysis revealed potential intramolecular interaction favorable electron delocalization region between both improve levels. Together, provides useful strategy structure-activity relationship (SAR) flavonoid distinct suggesting optimal functional positioning achieve balanced lipophilicity, effective bonding, simultaneously minimized steric hindrance specific types.

Language: Английский

Citations

0
Olefin metathesis in the synthesis of benzopyran, benzofuran and flavonoid scaffolds DOI
Barend C. B. Bezuidenhoudt, Charlene Marais

Advances in heterocyclic chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
A chromosome-level Dendrobium moniliforme genome assembly reveals the regulatory mechanisms of flavonoid and carotenoid biosynthesis pathways DOI Creative Commons
Jiapeng Yang, Qiqian Xue, Chao Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Kaempferide enhances type I interferon signaling as a novel broad-spectrum antiviral agent DOI
Ruikun Du, Jiawen Sun, Chunlei Zhang

et al.

Antiviral Research, Journal Year: 2025, Volume and Issue: unknown, P. 106141 - 106141

Published: March 1, 2025

Language: Английский

Citations

0
Identification and Functional Characterization of Two UDP-Glycosyltransferases Involved in Narcissoside Biosynthesis in Anoectochilus roxburghii DOI
Xuhui He, Hongrui Wang, Mingyue Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Flavonoid rutinosides, a group of bioactive compounds in Anoectochilus roxburghii, contribute greatly to the plant's beneficial effects on human health. However, glycosylation mechanism flavonoid rutinosides A. roxburghii remains unclear. In this study, two efficient and selective glycosyltransferases, AUTG25 AUTG23, involved biosynthesis narcissoside, major rutinoside were identified through transcriptome analysis functional validation. could regioselectively catalyze 3-O-glucosylation isorhamnetin produce 3-O-glucoside, while AUTG23 further 6"-O-rhamnosylation generate narcissoside. Both exhibited high positional sugar donor selectivities catalytic reaction. Homology modeling site-directed mutagenesis showed that H20, E83, E385, F143 E280, E89, D188, W327, D369, Y191 may be critical for their functions. Transient expression Nicotiana benthamiana finally confirmed possesses flavonol-3-O-glucosyltransferase activity has flavonol-3-O-glucoside (1→6) rhamnosyltransferase activity. This study clarified provided candidate UDP-dependent glycosyltransferase genes narcissoside roxburghii.

Language: Английский

Citations

0