Nanomedicine,
Journal Year:
2024,
Volume and Issue:
20(3), P. 305 - 318
Published: Dec. 30, 2024
Colorectal
cancer
(CRC)
is
a
significant
threat
to
human
health.
The
dynamic
equilibrium
between
probiotics
and
pathogenic
bacteria
within
the
gut
microbiota
crucial
in
mitigating
risk
of
CRC.
An
overgrowth
harmful
microorganisms
gastrointestinal
tract
can
result
an
excessive
accumulation
bacterial
toxins
carcinogenic
metabolites,
thereby
disrupting
delicate
balance
microbiota.
This
disruption
may
lead
alterations
microbial
composition,
impairment
mucosal
barrier
function,
potential
promotion
abnormal
cell
proliferation,
ultimately
contribute
progression
Recently,
research
has
indicated
that
intestinal
presence
Fusobacterium
nucleatum
(Fn)
significantly
influences
onset,
progression,
metastasis
Consequently,
interaction
CRC
cells
Fn
presents
promising
strategy
against
Nanomaterials
have
been
extensively
utilized
therapy
infection
control,
demonstrating
substantial
treating
bacteria-associated
tumors.
review
begins
by
elucidating
mechanisms
occurrence
CRC,
with
particular
emphasis
on
clarifying
intricate
relationship
Subsequently,
we
highlight
strategies
utilize
nanomaterials
disrupt
association
Overall,
this
offers
valuable
insight
guidance
for
leveraging
therapy.
Frontiers in Microbiology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 12, 2025
In
recent
years,
the
importance
of
gut
microbiota
in
digestive
absorption,
metabolism,
and
immunity
has
garnered
increasing
attention.
China
possess
abundant
horse
breed
resources,
particularly
Guizhou
horses,
which
play
vital
roles
local
agriculture,
tourism,
transportation.
Despite
this,
there
is
a
lack
comparative
studies
on
native
horses
(GZH)
imported
Dutch
Warmblood
(WH).
To
address
this
gap,
fecal
samples
were
collected
from
both
GZH
WH,
16S
rRNA
high-throughput
sequencing
was
utilized
to
analyze
differences
their
microbiota.
The
results
indicated
that
compared
with
GZH,
abundance
bacterial
community
WH
significantly
higher,
whereas
fungal
lower.
Furthermore,
PCoA-based
scatter
plot
analysis
demonstrated
distinct
structure
bacteria
fungi
between
two
breeds.
While
types
share
similar
major
phyla,
significant
observed
numerous
genera.
Moreover,
functional
predictions
communities
suggested
exhibit
more
robust
system
enhanced
glycan
biosynthesis
metabolism
capabilities.
This
first
report
WH.
emphasize
among
various
breeds
offer
valuable
insights
into
composition
different
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 2040 - 2040
Published: March 17, 2025
Oncologists
increasingly
recognize
the
microbiome
as
an
important
facilitator
of
health
well
a
contributor
to
disease,
including,
specifically,
cancer.
Our
knowledge
etiologies,
mechanisms,
and
modulation
states
that
ameliorate
or
promote
cancer
continues
evolve.
The
progressive
refinement
adoption
“omic”
technologies
(genomics,
transcriptomics,
proteomics,
metabolomics)
utilization
advanced
computational
methods
accelerate
this
evolution.
academic
center
network,
with
its
immediate
access
extensive,
multidisciplinary
expertise
scientific
resources,
has
potential
catalyze
research.
Here,
we
review
our
current
understanding
role
gut
in
prevention,
predisposition,
response
therapy.
We
underscore
promise
operationalizing
network
uncover
structure
function
microbiome;
highlight
unique
microbiome-related
expert
resources
available
at
City
Hope
Comprehensive
Cancer
Center
example
team
science
achieve
novel
clinical
discovery.
Gut Microbes,
Journal Year:
2025,
Volume and Issue:
17(1)
Published: April 6, 2025
Cancer
is
a
long-term
illness
that
involves
an
imbalance
in
cellular
and
immune
functions.
It
can
be
caused
by
range
of
factors,
including
exposure
to
environmental
carcinogens,
poor
diet,
infections,
genetic
alterations.
Maintaining
healthy
gut
microbiome
crucial
for
overall
health,
short-chain
fatty
acids
(SCFAs)
produced
microbiota
play
vital
role
this
process.
Recent
research
has
established
alterations
the
led
decreased
production
SCFA's
lumen
colon,
which
associated
with
changes
intestinal
epithelial
barrier
function,
immunity,
are
closely
linked
colorectal
cancer
(CRC)
development
its
progression.
SCFAs
influence
progression
modifying
epigenetic
mechanisms
such
as
DNA
methylation,
histone
modifications,
non-coding
RNA
functions
thereby
affecting
tumor
initiation
metastasis.
This
suggests
restoring
SCFA
levels
colon
through
modulation
could
serve
innovative
strategy
CRC
prevention
treatment.
review
highlights
critical
relationship
between
CRC,
emphasizing
potential
targeting
enhance
health
reduce
risk.
World Journal of Experimental Medicine,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: April 11, 2025
The
gut
microbiome,
a
complex
ecosystem
of
microorganisms,
has
significant
role
in
modulating
pain,
particularly
within
orthopaedic
conditions.
Its
impact
on
immune
and
neurological
functions
is
underscored
by
the
gut-brain
axis,
which
influences
inflammation,
pain
perception,
systemic
responses.
This
integrative
review
examines
current
research
how
dysbiosis
associated
with
various
pathways,
notably
nociceptive
neuroinflammatory
mechanisms
linked
to
central
sensitization.
We
highlight
advancements
meta-omics
technologies,
such
as
metagenomics
metaproteomics,
deepen
our
understanding
microbiome-host
interactions
their
implications
pain.
Recent
studies
emphasize
that
gut-derived
short-chain
fatty
acids
microbial
metabolites
play
roles
neuroinflammation
nociception,
contributing
management.
Probiotics,
prebiotics,
synbiotics,
faecal
microbiome
transplants
are
explored
potential
therapeutic
strategies
alleviate
through
modulation,
offering
an
adjunct
or
alternative
opioids.
However,
variability
individual
microbiomes
poses
challenges
standardizing
these
treatments,
necessitating
further
rigorous
clinical
trials.
A
multidisciplinary
approach
combining
microbiology,
immunology,
neurology,
orthopaedics
essential
develop
innovative,
personalized
management
rooted
health,
transform
care.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 18, 2024
Patients
with
Immune-Mediated
Inflammatory
Diseases
(IMIDs)
are
known
to
have
an
elevated
risk
of
developing
cancer,
but
the
exact
causative
factors
remain
subject
ongoing
debate.
This
narrative
review
aims
present
available
evidence
concerning
intricate
relationship
between
these
two
conditions.
Environmental
influences
and
genetic
predisposition
lead
a
dysregulated
immune
response
resulting
in
chronic
inflammation,
which
is
crucial
pathogenesis
IMIDs
oncogenic
processes.
Mechanisms
such
as
inflammatory
microenvironment,
aberrant
intercellular
communication
due
abnormal
cytokine
levels,
excessive
reparative
responses,
pathological
angiogenesis
involved.
The
immunosuppression
from
treatments
further
adds
complexity
pathogenic
scenario.
In
conclusion,
this
highlights
critical
gaps
current
literature,
suggesting
potential
avenues
for
future
research.
interplay
cancer
necessitates
more
investigation
deepen
our
understanding
improve
patient
management.
Translational Breast Cancer Research,
Journal Year:
2024,
Volume and Issue:
5, P. 31 - 31
Published: Oct. 1, 2024
The
composition
of
gut
microbiota
plays
an
important
role
in
predicting
and
influencing
outcomes
cancer
treated
with
immunotherapy.
Our
objective
is
to
summarize
the
immunotherapy
breast
cancer.
Farmacja Polska,
Journal Year:
2024,
Volume and Issue:
80(2), P. 101 - 110
Published: June 26, 2024
Przedmiot
badań:
Wpływ
mikrobioty
na
efektywność
i
bezpieczeństwo
terapii
przeciwnowotworowych.
Mikrobiom
odgrywa
znaczącą
rolę
w
utrzymaniu
odporności.
Jego
zmienność
osobnicza
determinuje
wiele
procesów
fizjologicznych.
Do
zaburzenia
jego
homeostazy
może
prowadzić
czynników,
tym
leczenie
onkologiczne.
Cel
Badań:
Celem
pracy
jest
przedstawienie
aktualnych
doniesień
dotyczących
zależności
między
składem
a
odpowiedzią
terapie
przeciwnowotworowe.
Metodyka
wyszukiwania
doboru
piśmiennictwa:
Przeglądu
piśmiennictwa
dokonano
z
dostępnych
naukowych
baz:
PubMed,
Scopus
oraz
Google
Scholar.
Stosowano
słowa
kluczowe:
mikrobiota,
mikrobiom,
immunoterapia,
radioterapia,
chemioterapia,
rak,
nowotwór,
probiotyki.
Wyniki:
Badania
wykazały,
że
prawidłowa
mikrobiota
jelit
wpływa
skuteczność
przeciwnowotworowej
poprzez
liczne
procesy
takie
jak
interakcje
komórkami
nowotworowymi,
modulowanie
odpowiedzi
immunologicznej
ingerencje
metabolizm
leków.
Wskutek
leczenia
dochodzi
do
dysbiozy,
czyli
zmian
ilościowych
jakościowych
mikrobioty,
co
oddziałuje
negatywnie
terapii,
nasila
działania
niepożądane
obniżające
jakość
życia
pacjenta
onkologicznego.
W
celu
łagodzenia
zapobiegania
dolegliwościom
ze
strony
przewodu
pokarmowego
zalecana
suplementacja
przebadanymi
szczepami
bakterii
probiotycznych.
kliniczne
wyjaśniają
mechanizmy
potwierdzają
zasadność
stosowania
probiotyków
leczeniu
onkologicznym.
Wnioski:
Przegląd
potwierdza
wpływ
przeciwnowotworowego,
uwzględnia
także
zmiany
składu
wywołane
stosowaniem
różnych
schematów
leczenia.
Konieczne
są
dalsze
badania
kierunku
wraz
dokładnym
wyjaśnieniem
mechanizmów.
Szersze
analizy
uwzględniające
stan
o
danym
profilu
mikrobiologicznym
pozwolą
indywidualizację
farmakoterapii
zastosowaniem
odpowiednio
dobranej
suplementacji
probiotykami.
Ograniczy
to
niepożądane,
poprawi
samopoczucie
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
20(3), P. 305 - 318
Published: Dec. 30, 2024
Colorectal
cancer
(CRC)
is
a
significant
threat
to
human
health.
The
dynamic
equilibrium
between
probiotics
and
pathogenic
bacteria
within
the
gut
microbiota
crucial
in
mitigating
risk
of
CRC.
An
overgrowth
harmful
microorganisms
gastrointestinal
tract
can
result
an
excessive
accumulation
bacterial
toxins
carcinogenic
metabolites,
thereby
disrupting
delicate
balance
microbiota.
This
disruption
may
lead
alterations
microbial
composition,
impairment
mucosal
barrier
function,
potential
promotion
abnormal
cell
proliferation,
ultimately
contribute
progression
Recently,
research
has
indicated
that
intestinal
presence
Fusobacterium
nucleatum
(Fn)
significantly
influences
onset,
progression,
metastasis
Consequently,
interaction
CRC
cells
Fn
presents
promising
strategy
against
Nanomaterials
have
been
extensively
utilized
therapy
infection
control,
demonstrating
substantial
treating
bacteria-associated
tumors.
review
begins
by
elucidating
mechanisms
occurrence
CRC,
with
particular
emphasis
on
clarifying
intricate
relationship
Subsequently,
we
highlight
strategies
utilize
nanomaterials
disrupt
association
Overall,
this
offers
valuable
insight
guidance
for
leveraging
therapy.
