Will Lipid Oxidation Influence the Physiochemical Stability and Bioaccessibility of Rare Ginsenoside PPD Nanoemulsions? DOI
Shanshan Han, Yaowei Liu,

Tao Yang

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105760 - 105760

Published: Dec. 1, 2024

Language: Английский

Ginsenoside Rk2 alleviates hepatic ischemia/reperfusion injury by enhancing AKT membrane translocation and activation DOI Creative Commons
Hong Shen, Jiajun Fu, Jiayue Liu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Hepatic ischemia-reperfusion injury (IRI) poses a significant threat to clinical outcomes and graft survival during hemorrhagic shock, hepatic resection, liver transplantation. Current pharmacological interventions for IRI are inadequate. In this study, we identified ginsenoside Rk2 (Rk2), rare dehydroprotopanaxadiol saponin, as promising agent against through high-throughput screening. The effects molecular mechanisms of on were further evaluated elucidated in vitro vivo. significantly reduced inflammation apoptosis caused by oxygen-glucose deprivation reperfusion hepatocytes dose dependently protected I/R-induced mice. Integrated approaches, including network pharmacology, docking, transcriptome analysis, isothermal titration calorimetry, along with experimental validation, indicated that protects targeting activating the AKT (RAC serine/threonine protein kinase) signaling pathway. Pharmacological inhibition pathway or knockdown AKT1 effectively diminished protective Rk2. directly binds AKT1, facilitating its translocation from cytoplasm plasma membrane. This process markedly enhanced interaction PDPK1, promoting activation downstream signaling. Our findings demonstrate direct binding membrane translocation.

Language: Английский

Citations

2
Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3‐O‐UGT2 DOI Creative Commons
Qiushuang Ji, Yirong Liu, Huanyu Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Ginsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting ginseng aglycone attached to various glycans. Pq3‐O‐UGT2, an important UDP‐dependent glycosyltransferase (UGT), catalyzes the production Ginsenoside Rg3 and Rd by extending glycan chain Rh2 F2, respectively, higher selectivity for F2. However, mechanism underlying its substrate recognition remains unclear. In this study, crystal structures Pq3‐O‐UGT2 in complex acceptor substrates solved. The revealed Nα5‐oriented binding pocket shaped unique conformation Nα5‐Nα6 linker. Hydrophobic interactions play pivotal role both while hydrogen bonds specifically aid F2 due additional glucose moiety. hydrophobic nature also enables recognize flavonoids. Overall, study provides novel insights into mechanisms ginsenoside UGTs, advancing understanding their function specificity.

Language: Английский

Citations

1
Advancements in enzymatic biotransformation and bioactivities of rare ginsenosides：A Review DOI

Hu Yanbo,

Yiming Li,

Yi Cao

et al.

Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 392, P. 78 - 89

Published: June 28, 2024

Language: Английский

Citations

7
Production and pharmaceutical research of minor saponins in Panax notoginseng (Sanqi): Current status and future prospects DOI
Hui Zhang, Jianxiu Li, Mengxue Diao

et al.

Phytochemistry, Journal Year: 2024, Volume and Issue: 223, P. 114099 - 114099

Published: April 18, 2024

Language: Английский

Citations

6
Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic Applications DOI
Lei Wu, Lin Bai, Wenshu Dai

et al.

Current Topics in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(10), P. 869 - 884

Published: March 5, 2024

Background: Traditional Chinese Medicine (TCM) has a long history of treating various diseases and is increasingly being recognized as complementary therapy for cancer. A promising natural compound extracted from the herb ginseng ginsenoside Rg3, which demonstrated significant anticancer effects. It been tested in variety cancers tumors proven to be effective suppressing Objective: This work covers aspects role Rg3 cancer treatment, including its biological functions, key pathways, epigenetics, potential combination therapies, all have extensively researched elucidated. The study aims provide reference future research on an agent support application treatment.

Language: Английский

Citations

5
Oxidation and Hydrolysis of Ginsenoside Rg5: An Underestimated Degradation Pathway, Isolation and Characterization of Unknown Degradation Products DOI
Yuewei Zhang,

Le-Qin Cheng,

Anqi Ye

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
The biosynthesis of trillin 6’-O-glucoside: a low-abundance yet pharmacologically active polyphyllin from Paris polyphylla DOI Creative Commons

Yaran Suo,

Shuyu Li, Haining Lyu

et al.

Synthetic and Systems Biotechnology, Journal Year: 2025, Volume and Issue: 10(2), P. 610 - 619

Published: March 1, 2025

Language: Английский

Citations

0
Protopanaxadiol (PPD)-type ginsenosides inhibit the key element of α-glucosidase - The glycosyl group DOI
Yiming Li,

Yuzhu Shen,

Xianjun Zou

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141843 - 141843

Published: March 7, 2025

Language: Английский

Citations

0
Ginsenosides from Panax ginseng modulate lipid mediator profiles in human leukocytes by interference with cellular 5-lipoxygenase activity DOI Creative Commons

Vera Bruggink,

Caroline Gutjahr,

Angelika Decker

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116882 - 116882

Published: March 1, 2025

Lipid mediators are a superfamily of bioactive molecules that crucially involved in immune responses, regulating all stages inflammation. Panax (P.) ginseng has pleiotropic pharmacological effects, including anti-cancer, anti-diabetic, and anti-inflammatory properties. Ginsenosides, unique triterpenoid glycosides from the plant's root, proposed as active ingredients responsible for immunomodulating potential P.ginseng. Here, we comprehensively screened 23 ginsenosides manipulating lipid mediator network various primary human innate cells. Several selectively inhibited 5-lipoxygenase (5-LOX)-mediated formation pro-inflammatory leukotriene B4, but not prostaglandins, monocyte-derived macrophages polymorphonuclear leukocytes by irreversible mechanism. Structure-activity relationships revealed (i) higher anti-5-LOX activity PPD-type ginsenosides, (ii) correlation with lipophilicity (R2 = 0.91), (iii) eudysmic ratios favoring 20S-epimers. Our findings highlight immunomodulatory principles P. reveal abrogation rather than interference prostaglandins immediate

Language: Английский

Citations

0
New labdane diterpenoid glycosides from the leaves and flowers of Leucosceptrum canum DOI
Xin Yuan,

Xiao-Ping He,

Yongnan Xu

et al.

Tetrahedron Letters, Journal Year: 2025, Volume and Issue: unknown, P. 155554 - 155554

Published: March 1, 2025

Language: Английский

Citations

0