SARS-CoV-2 Phylointeractomics Reveal Functional Evolution of Its Variants Across Susceptible Human Organs DOI Creative Commons
Xu Li,

Peihan Wu,

Danqi Bao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly infects the tissues of human respiratory, nervous, digestive and urinary systems. Here, we conducted an integrated study viral–host protein‒protein interactions between 29 wildtype SARS-CoV-2 proteins 15 variant S lung-, bronchus-, neuron-, liver- kidney-derived cells, identified 745,163 established phylointeractomics variants across susceptible organs. We highlighted interacting involved in function evolution viral under different cellular contexts, several as potential drug targets for treating related complications sequalae. The results reveal how various contribute to infection, replication immune evasion by with general cell type-specific host proteins.

Language: Английский

Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury DOI
Mengjie Li, Gang Li, Liu Y

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Pulmonary inflammation is the main cause of lung injury. Phosphodiesterase 4 (PDE4) a promising anti-inflammatory target for treatment respiratory diseases. Herein, we designed and synthesized 43 compounds in two novel series benzimidazole derivatives as PDE4 inhibitors. Among them, compound A5 showed highly selective inhibition PDE4, good safety, liver microsomal stability vitro. administration remarkably attenuated inflammatory infiltration pathologic injury models acute mice chronic obstructive pulmonary disease (COPD) mice. In addition, enhanced sputum secretion, relieved cough mice, inhibited phosphorylation p38 MAP kinase, an important protein regulation Overall, A5, effective inhibitor without toxicity gastrointestinal reaction, may be potent candidate

Language: Английский

Citations

0
Inhibition of Inflammatory Regulators for Chronic Obstructive Pulmonary Disease (COPD) Treatment from Indonesian Medicinal Plants: A Systematic Review DOI Creative Commons
Dyah Iswantini,

Min Rahminiwati,

Trivadila Trivadila

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 262 - 262

Published: April 8, 2025

A characteristic of Chronic Obstructive Pulmonary Disease (COPD) is the inflammation respiratory pathway. Inflammatory regulators affected in COPD include cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), interleukin (IL-1β), and interleukin-6 (IL-6). Therefore, this systematic review aimed to investigate biological activity Indonesian medicinal plants as anti-inflammation through vitro, silico, vivo studies. digital search was conducted using Scopus, Google Scholar, PubMed online databases find relevant articles by applying specific keywords related subject interest. The results showed 18 studies that reported five proven inhibit regulation. were sambiloto (Andrographis paniculata), legetan warak (Adenostemma lavenia), kersen (Muntingia calabura), babadotan (Ageratum conyzoides), sembung rambat (Mikania micrantha Kunth). In vitro studies, A. paniculata, lavenia, M. calabura can suppress levels pro-inflammatory cytokines, such TNF-α, IL-1β, IL-6, LPS-stimulated RAW 264.7 cells. silico compounds have strong binding bind inflammatory receptors are andrographiside contained paniculata; ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic acid lavenia; 7-Hydroxyflavone calabura; 22,23-Dihydrospinasterol conyzoides. extracts calabura, conyzoides, reduce lung tissue animal models (hamsters, mice, rats). This might help develop treatment build scientifically natural products from for future investigations.

Language: Английский

Citations

0
Phycocyanin-based multifunctional microspheres for treatment of infected radiation-induced skin injury DOI
Jiajia Dong, Yutong Lang,

Jian He

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 317, P. 123061 - 123061

Published: Dec. 26, 2024

Language: Английский

Citations

0
SARS-CoV-2 Phylointeractomics Reveal Functional Evolution of Its Variants Across Susceptible Human Organs DOI Creative Commons
Xu Li,

Peihan Wu,

Danqi Bao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 23, 2024

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mainly infects the tissues of human respiratory, nervous, digestive and urinary systems. Here, we conducted an integrated study viral–host protein‒protein interactions between 29 wildtype SARS-CoV-2 proteins 15 variant S lung-, bronchus-, neuron-, liver- kidney-derived cells, identified 745,163 established phylointeractomics variants across susceptible organs. We highlighted interacting involved in function evolution viral under different cellular contexts, several as potential drug targets for treating related complications sequalae. The results reveal how various contribute to infection, replication immune evasion by with general cell type-specific host proteins.

Language: Английский

Citations

0