Digging Through the Complexities of Immunological Approaches in Emerging Osteosarcoma Therapeutics: A Comprehensive Narrative Review with Updated Clinical Trials
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(3), P. 664 - 664
Published: March 8, 2025
Osteosarcoma
(OS)
is
the
predominant
mesenchymal
primary
malignant
bone
tumor
in
oncology
and
pathology,
impacting
a
wide
age
range
from
adolescents
to
older
adults.
It
frequently
advances
lung
metastasis,
ultimately
resulting
mortality
of
OS
patients.
The
precise
pathological
pathways
responsible
for
progression
dissemination
are
not
fully
understood
due
its
heterogeneity.
integration
surgery
with
neoadjuvant
postoperative
chemotherapy
has
significantly
increased
5-year
survival
rate
more
than
70%
patients
localized
tumors.
However,
about
30%
experience
local
recurrence
and/or
metastasis.
Hence,
there
requirement
innovative
therapeutic
approaches
address
limitations
traditional
treatments.
Immunotherapy
garnered
increasing
attention
as
promising
avenue
tumors
resistant
standard
therapies,
including
OS,
despite
underlying
mechanisms
disease
remaining
well
elucidated.
may
have
been
suitable
use
because
tumor’s
immunosuppressive
microenvironment
limited
immunogenicity.
Nevertheless,
immune-based
treatments
now
being
developed
clinical
use,
such
bispecific
antibodies,
chimeric
antigen
receptor
T
cells,
immune
checkpoint
inhibitors.
Also,
additional
immunotherapy
techniques
cytokines,
vaccines,
modified-Natural
Killer
(NK)
cells/macrophages
early
phases
research
but
will
certainly
be
popular
subjects
nearest
future.
Our
goal
writing
this
review
was
spark
new
lines
inquiry
into
by
summarizing
findings
both
preclinical
current
studies
examining
different
approaches.
Language: Английский
Turning cold into hot: emerging strategies to fire up the tumor microenvironment
Trends in cancer,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Language: Английский
Recent innovations in machine learning for skin cancer lesion analysis and classification: A comprehensive analysis of computer‐aided diagnosis
Precision Medical Sciences,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
The
global
primary
health
concern
of
skin
cancer
emphasizes
the
need
for
quick
and
accurate
diagnosis
to
improve
patient
outcomes.
Although,
it
might
be
challenging
evaluate
possible
risk
a
spot
merely
by
looking
at
feeling
it.
This
review
article
offers
thorough
overview
current
breakthroughs
in
machine
learning
(ML)
computer‐aided
diagnostics
(CAD)
aim
analysis
classification
lesions
over
past
6
years.
paper
carefully
reviews
whole
diagnostic
process:
data
preparation,
lesion
segmentation,
feature
extraction,
selection,
final
classification.
Analyzed
are
many
publicly
accessible
datasets
creative
ideas
including
deep
(DL)
ML
integrated
with
computer
vision,
together
their
impact
on
increasing
accuracy.
Given
variety
complexity
lesions,
even
enormous
progress,
there
still
major
obstacles.
rigorously
assesses
methods,
notes
areas
great
challenge,
provides
recommendations
direct
next
research
targeted
improving
early
detection
strategies
CAD
systems.
Language: Английский
Inflammation in Penile Squamous Cell Carcinoma: A Comprehensive Review
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2785 - 2785
Published: March 19, 2025
Inflammation
appears
to
play
a
crucial
role
in
the
development
and
progression
of
penile
cancer
(PeCa).
Two
molecular
pathways
PeCa
are
currently
described:
HPV-dependent
HPV-independent.
The
tumor
immune
microenvironment
(TIME)
is
characterized
by
presence
tumor-associated
macrophages,
cancer-associated
fibroblasts,
tumor-infiltrating
lymphocytes.
components
TIME
produce
pro-inflammatory
cytokines
chemokines,
which
have
been
found
be
overexpressed
tissues
associated
with
unfavorable
prognoses.
Additionally,
nuclear
factor
kappa
B
(NF-κB)
pathway
secreted
phosphoprotein
1
(SPP1)
implicated
pathogenesis.
Elevated
C-reactive
protein
(CRP)
levels
neutrophil-to-lymphocyte
ratio
(NLR)
identified
as
potential
prognostic
biomarkers
PeCa.
This
overview
presents
complex
contribution
inflammatory
process
collates
projects
aimed
at
modulating
Language: Английский
Immune Modulation and Immunotherapy in Solid Tumors: Mechanisms of Resistance and Potential Therapeutic Strategies
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 2923 - 2923
Published: March 24, 2025
Understanding
the
modulation
of
specific
immune
cells
within
tumor
microenvironment
(TME)
offers
new
hope
in
cancer
treatments,
especially
immunotherapies.
In
recent
years,
and
resistance
to
immunotherapy
have
become
critical
challenges
treatments.
However,
novel
strategies
for
emerged
as
promising
approaches
oncology
due
vital
roles
immunomodulators
regulating
progression
metastasis
modulating
immunological
responses
standard
care
With
progress
immuno-oncology,
a
growing
number
mechanisms
are
being
uncovered,
offering
potential
enhanced
clinical
near
future.
Thus,
gaining
comprehensive
understanding
broader
context
is
essential.
Herein,
we
particularly
summarize
paradoxical
role
tumor-related
cells,
focusing
on
how
targeted
their
actions
modulated
by
immunotherapies
overcome
immunotherapeutic
cells.
We
also
highlight
molecular
employed
tumors
evade
long-term
effects
agents,
rendering
them
ineffective.
Language: Английский