Journal of Bioscience and Bioengineering, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 21, 2024
Metabolic alterations, a hallmark of cancer, enable tumor cells to adapt their environment by modulating glucose, lipid, and amino acid metabolism, which fuels rapid growth contributes treatment resistance. In primary breast metabolic shifts such as the Warburg effect enhanced lipid synthesis are closely linked chemotherapy failure. Similarly, metastatic lesions often display distinct profiles that not only sustain but also confer resistance targeted therapies immunotherapies. The review emphasizes two major aspects: mechanisms driving in both how unique environments sites further complicate treatment. By targeting vulnerabilities at stages, new strategies could improve efficacy existing provide better outcomes for cancer patients.
Language: Английский
Citations
16
iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111705 - 111705
Published: Jan. 5, 2025
Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role clinical practice. This blood derivative, enriched platelet components, shown great potential for promoting tissue repair and regeneration. Its wide range of applications presence anti-inflammatory growth-promoting factors make it valuable tool field biomedicine. The exploration PRP settings been gaining momentum. Despite its cost-effectiveness, safety, therapeutic efficacy, widespread adoption hindered by absence consistent preparation standards standardized treatment protocols. article provides comprehensive analysis uses, physiological roles, molecular mechanisms, techniques aim is to offer thorough understanding benefits medical
Language: Английский
Citations
2
Experimental Eye Research, Journal Year: 2025, Volume and Issue: unknown, P. 110243 - 110243
Published: Jan. 1, 2025
Language: Английский
Citations
1
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102536 - 102536
Published: Oct. 9, 2024
Language: Английский
Citations
6
Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(2)
Published: Jan. 27, 2025
ABSTRACT The aryl hydrocarbon receptor (AhR), a ligand‐activated transcription factor, is extensively expressed in diverse human organs and plays pivotal role mediating the onset, progression, severity of numerous diseases. Recent research has explored substantial impact AhR on skin homeostasis related pathologies. As multi‐layered organ, comprises multiple cell populations that express AhR. In this review, we introduce various cells its barrier function. Furthermore, explore involvement development diseases, highlighting potential as therapeutic target for disorders. By targeting AhR, may open new avenues novel efficient disease treatments.
Language: Английский
Citations
0
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 201 - 201
Published: Jan. 31, 2025
Acute and chronic coronary artery disease (CAD) are interconnected, representing two facets of the same condition. Chronic CAD exhibits a dynamic nature, manifesting as stable or acute ischemia, both. Myocardial ischemia can be transient reversible. The genesis involves diverse anatomical functional mechanisms, including endothelial dysfunction, arteriolar remodeling, capillary rarefaction, perivascular fibrosis, though no single factor explains its heterogeneity. is often but may present symptomatic asymptomatic (e.g., in diabetes) affect various compartments (epicardial microcirculation). This complexity necessitates reappraisal our approach, pathophysiological mechanisms vary overlap. A comprehensive exploration these using advanced diagnostic techniques aid identifying processes underlying CAD. obstructive non-obstructive, unstable, underscoring diversity. primary source lies arterial wall, emphasizing need for research on components, such endothelium vascular smooth muscle cells, factors disrupting homeostasis. Shifting focus from luminal status to wall provide insights into atheromatous plaques, enabling earlier interventions prevent their development progression.
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 12, 2025
Extracellular vesicles derived from pericytes (PCEVs) have been shown to improve vascular permeability, with their therapeutic effects attributed the presence of pro-regenerative molecules. We hypothesized that angiopoietin 1 (Angpt1) carried by PCEVs contributes after sepsis. A cecal ligation and puncture (CLP)-induced sepsis rat model was used in vivo, on endothelial cells were studied vitro. First, proteomic Gene Ontology enrichment analyses performed analyze mechanism PCEVs, revealing angiogenesis-related protein Angpt1 highly expressed PCEVs. then down-regulated The role PCEV-carried intestinal barrier function, PCs recruitment, inflammatory cytokines measured using septic Sprague–Dawley rats platelet-derived growth factor receptor beta (PDGFR-β)-Cre + mT/mG transgenic mice. significantly improved proliferation, angiogenesis CLP-induced gut injury both vivo Further studies exert a protective effect function PC recruitment. Additionally, reduced serum levels. Our data also demonstrated levels phospho-PI3K phospho-Akt increased administration, whereas knocking out suppressed through decreased activation PI3K/Akt signaling. protect against regulating barrier, promoting protecting restoring properties via Angpt1/PI3K/AKT pathway.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141831 - 141831
Published: March 1, 2025
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)
Published: March 13, 2025
Language: Английский
Citations
0
International Ophthalmology, Journal Year: 2025, Volume and Issue: 45(1)
Published: March 25, 2025
Language: Английский
Citations
0