The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease DOI Creative Commons
Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali

et al.

Life, Journal Year: 2024, Volume and Issue: 15(1), P. 3 - 3

Published: Dec. 24, 2024

The human microbiota constitute a very complex ecosystem of microorganisms inhabiting both the inside and outside our bodies, in which health maintenance disease modification are main regulatory features. recent explosion microbiome research has begun to detail its important role neurological health, particularly concerning cerebral small vessel (CSVD), disorder associated with cognitive decline vascular dementia. This narrative review represents state-of-the-art knowledge intimate, interplay between brain through gut-brain axis (GBA) emerging glymphatic system dysfunction (glymphopathy) circulating cell-derived microparticles (MPs) as mediators these interactions. We discuss how microbial dysbiosis promotes neuroinflammation, dysfunction, impaired waste clearance brain, critical factors pathogenesis CSVD. Further, we lifestyle that shape composition functionality microbiota, focusing on sleep modifiable risk factor disorders. presents from neuroscientific perspective establish future therapeutic avenues targeting improve reduce burden

Language: Английский

Comprehensive method for isolation and functional characterization of bacterial vesicles from human biological samples DOI

Swati Thangariyal,

Sujata V. Bhat, Ashmit Mittal

et al.

Methods, Journal Year: 2025, Volume and Issue: 237, P. 1 - 8

Published: Feb. 27, 2025

Language: Английский

Citations

0
Gut microbiota-derived extracellular vesicles form a distinct entity from gut microbiota DOI Creative Commons
Anna Kaisanlahti, Jenni Turunen, Jenni Hekkala

et al.

mSystems, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

ABSTRACT Extracellular vesicles (EVs), nanoparticles secreted by both gram-negative and gram-positive bacteria, carry various biomolecules cross biological barriers. Gut microbiota-derived EVs are currently being investigated as a communication mechanism between the microbiota host. Few clinical studies, however, have gut EVs. Here, we show that machine learning models were able to accurately distinguish respective EV samples according their taxonomic composition within each data set (area under curve [AUC] 0.764–1.00) in cross-study setting (AUC 0.701–0.997). These results form distinct entity from microbiota. Thus, conventional may not correctly reflect host unless reported separately. IMPORTANCE extracellular (EVs) been suggested be human body. However, on secretion remain limited. To investigate compare of composition, used approach classify 16S rRNA gene sequencing seven sets incorporating samples. The study separate should included studies gain more comprehensive insight into microbiota–host communication.

Language: Английский

Citations

0
The proteomic landscape of stool-derived extracellular vesicles in patients with pre-cancerous lesions and colorectal cancer DOI Creative Commons
Emmalee J. Northrop‐Albrecht, Yohan Kim,

William R. Taylor

et al.

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Feb. 13, 2025

Language: Английский

Citations

0
Bacterial extracellular vesicles for gut microbiome-host communication and drug development DOI Creative Commons

Dingfei Qian,

Panpan Xu, Xinwei Wang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Citations

0
The potential use of bacteria and their derivatives as delivery systems for nanoparticles in the treatment of cancer DOI
Shiva Ahmadishoar, Saba Saeed,

Morug Salih Mahdi

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 54

Published: April 5, 2025

Cancer is a leading cause of mortality and morbidity worldwide. Nanomaterials, unique optical, magnetic, electrical properties at the nanoscale (1-100 nm), have been engineered to improve drug capacity, bioavailability, specificity in cancer treatment. These advancements address toxicity lack selectivity conventional therapies, enabling precise targeting cells, tumor microenvironment, immune system. Among emerging approaches, bacterial treatment shows promise due its natural ability target diverse therapeutic mechanisms, which nanotechnology can further enhance. Bacteria-based delivery systems leverage bacteria's adaptability survival strategies within human body. Bacterial derivatives, such as ghosts (BGs), extracellular vesicles (BEVs), dietary toxins, are recognized effective biological nanomaterials capable carrying nanoparticles (NPs). attracted increasing attention for their potential targeted NP This study explores use various bacteria byproducts vehicles, highlighting treating different types cancer. By combining strengths therapy, these innovative approaches aim revolutionize with improved precision efficacy.

Language: Английский

Citations

0
Applications of Urinary Extracellular Vesicles in the Diagnosis and Active Surveillance of Prostate Cancer DOI Open Access
S. F. Smith, Daniel Brewer, Rachel Hurst

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1717 - 1717

Published: April 28, 2024

Prostate cancer is the most common non-cutaneous among men in UK, causing significant health and economic burdens. Diagnosis risk prognostication can be challenging due to genetic clinical heterogeneity of prostate as well uncertainties our knowledge underlying biology natural history disease development. Urinary extracellular vesicles (EVs) are microscopic, lipid bilayer defined particles released by cells that carry a variety molecular cargoes including nucleic acids, proteins other molecules. Urine plentiful source prostate-derived EVs. In this narrative review, we summarise evidence on function urinary EVs their applications evolving field diagnostics active surveillance. implicated development all hallmarks cancer, has been applied multiple diagnostic tests, which largely based RNA miRNA. Common gene probes included multi-probe tests include PCA3 ERG, miRNAs miR-21 miR-141. The next decade will likely bring further improvements accuracy biomarkers insights into biological mechanisms action translated opportunities precision uro-oncology.

Language: Английский

Citations

1
Microbial Biomarkers in Liquid Biopsy for Cancer: An Overview and Future Directions DOI Creative Commons

Feiyang Luo,

Xinyue Wang, Chun Ye

et al.

Cancer Control, Journal Year: 2024, Volume and Issue: 31

Published: Jan. 1, 2024

In recent years, the relationship between microbes and tumors has led to a new wave of scholarly pursuits. Due growing awareness importance microbiota, including those within tumors, for cancer onset, progression, metastasis, treatment, researchers have come understand that microbiota tumor microenvironment together form dynamic complex ecosystem. Liquid biopsy technology, non-invasive easily repeatable method sample collection, combined with emerging multi-omics techniques, allows more comprehensive in-depth exploration microbial signals characteristics in bodily fluids. Microbial biomarkers hold immense potential early diagnosis, treatment stratification, prognosis prediction cancer. this review, we describe significant liquid clinical applications cancer, predicting responses, prognosis. Moreover, discuss current limitations solutions related biomarkers. This review aims provide an overview future directions practice.

Language: Английский

Citations

1
Proton pump inhibitors reduce chemotherapeutic hepatotoxicity and enhance hepatic uptake and accumulation of drug-loaded extracellular vesicles DOI Creative Commons
Mengyu Li,

Weiyi Yuan,

Xianghui Kong

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 15, 2024

Extracellular vesicles (EVs) are involved in the progression of various diseases. Tumor cell-derived EVs (TEVs) a particular concern, as they can induce fatty liver by promoting macrophages to secrete tumor necrosis factor (TNF), thus enhancing toxicity chemotherapy. Therefore, reducing pathogenic EV production is potential strategy for treating EV-related However, there currently no effective clinical reagents obtain this purpose. In addition, also natural and ideal drug-delivery vehicles. Improving delivery efficiency remains challenge. Proton pump inhibitors (PPIs) have been demonstrated promote cell uptake inducing micropinocytosis. Here, we show that PPIs accelerate TEV clearance, reduce decrease mRNA expression TNF tumor-bearing mice. Correspondingly, phenotypes alleviated, tolerance chemotherapy improved these Furthermore, our findings indicate facilitate red blood (RBC-EVs) loaded with antisense oligonucleotides Trim21 (Trim21-ASOs) obesity. Consequently, inhibition macrophage inflammatory responses obese mice mediated RBC-EVs/Trim21-ASOs was further enhanced PPIs, resulting more profound improvement obesity related metabolic disorders. conclusion, effectively clear enhance efficacy vehicles, making them highly promising prospect.

Language: Английский

Citations

0
Emerging role of gut microbiota extracellular vesicle in neurodegenerative disorders and insights on their therapeutic management DOI Creative Commons
Adil Hassan, Yin Huang,

Mahjabina

et al.

iMetaOmics., Journal Year: 2024, Volume and Issue: 1(2)

Published: Oct. 25, 2024

Abstract Targeting gut flora to lower sickness risk is a growing scientific subject. The intricate network of microorganisms (gut microbiota) in the human intestines regulates many physiological systems and may be important for general health. Recent research has shown dynamic relationship between microbiota central nervous system (CNS). Dysbiosis key establishing progressing diseases, including neurodegenerative disorders. Recently, extracellular vesicles (GMEVs) have been suggested as brain‐gut communication carriers. Vesicle components contact immune receptors, initiating neuroinflammatory responses causing diseases. This study seeks explain how its cause or worsen We also highlighted recent advances our understanding these GMEVs' cargo's routes, which could used drug delivery treatments. examines current state potential therapeutic effects GMEVs on illnesses.

Language: Английский

Citations

0
The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease DOI Creative Commons
Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali

et al.

Life, Journal Year: 2024, Volume and Issue: 15(1), P. 3 - 3

Published: Dec. 24, 2024

The human microbiota constitute a very complex ecosystem of microorganisms inhabiting both the inside and outside our bodies, in which health maintenance disease modification are main regulatory features. recent explosion microbiome research has begun to detail its important role neurological health, particularly concerning cerebral small vessel (CSVD), disorder associated with cognitive decline vascular dementia. This narrative review represents state-of-the-art knowledge intimate, interplay between brain through gut-brain axis (GBA) emerging glymphatic system dysfunction (glymphopathy) circulating cell-derived microparticles (MPs) as mediators these interactions. We discuss how microbial dysbiosis promotes neuroinflammation, dysfunction, impaired waste clearance brain, critical factors pathogenesis CSVD. Further, we lifestyle that shape composition functionality microbiota, focusing on sleep modifiable risk factor disorders. presents from neuroscientific perspective establish future therapeutic avenues targeting improve reduce burden

Language: Английский

Citations

0