XRCC2 knockdown effectively sensitizes esophageal cancer to albumin-paclitaxel in vitro and in vivo DOI
Jia Xu, Xiao‐Yuan Liu, Zebo Huang

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Language: Английский

Reduce electrical overload via threaded Chinese acupuncture in nerve electrical therapy DOI Creative Commons
Yupu Liu, Yawei Du, Juan Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 46, P. 476 - 493

Published: Jan. 5, 2025

Language: Английский

Citations

2
The intersection of the nervous system and breast cancer DOI
Yutong Liu,

Shiqi Yin,

Guanyu Lu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217132 - 217132

Published: July 24, 2024

Language: Английский

Citations

13
ARA290, an alternative of erythropoietin, inhibits activation of NLRP3 inflammasome in Schwann cells after sciatic nerve injury DOI
Guixian Liu, Wei Li,

Suli Jiang

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177610 - 177610

Published: April 1, 2025

Language: Английский

Citations

0
TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism DOI Creative Commons
Hao Zhang,

Xiangxu Kong,

Wei Wang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Abstract The global incidence of Metabolic dysfunction‐associated steatohepatitis (MASH) is increasing, highlighting the urgent need for new treatment strategies. This study aimed to investigate involvement tripartite motif‐containing 25 (TRIM25) in MASH progression and explore therapeutic potential TRIM25 inhibitor, C 27 H 26 N 2 O 4 S. Functional studies reveal that promoted lipid accumulation inflammation by ubiquitinating degrading insulin‐induced gene 1 (INSIG1), thereby enhancing nuclear translocation sterol regulatory element‐binding protein (SREBP2) upregulating biosynthesis genes. In vivo experiments using knockout mice demonstrated deletion ameliorated progression, reduced fibrosis, decreased inflammatory cell infiltration. It identifies S as a specific inhibitor TRIM25. effectively INSIG1 ubiquitination attenuated hepatocytes. To enhance hepatic delivery S, it utilizes exosomes derived from stellate cells (HSC‐EVs). Biodistribution analysis confirmed HSC‐EVs preferentially accumulated liver. mouse model, HSC‐EV‐encapsulated (C S@HSC‐EV) significantly alleviated severity fibrosis. highlights critical role presents S@HSC‐EV promising approach treatment.

Language: Английский

Citations

0
XRCC2 knockdown effectively sensitizes esophageal cancer to albumin-paclitaxel in vitro and in vivo DOI
Jia Xu, Xiao‐Yuan Liu, Zebo Huang

et al.

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

Language: Английский

Citations

1