Efferocytosis: The Janus‐Faced Gatekeeper of Aging and Tumor Fate

Aging Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

ABSTRACT From embryogenesis to aging, billions of cells perish daily in mammals. The multistep process by which phagocytes engulf these deceased without eliciting an inflammatory response is called efferocytosis. Despite significant insights into the fundamental mechanisms efferocytosis, its implications disorders such as aging and cancer remain elusive. Upon summarizing analyzing existing studies on it becomes evident that efferocytosis our friend resolving inflammation, yet transforms foe facilitating tumor development metastasis. This review illuminates recent discoveries regarding emerging clearing apoptotic cells, explores connections with examines influence metastasis, identifies regulatory factors within microenvironment. A comprehensive understanding facets offers crucial physiological pathophysiological processes, paving way for innovative therapeutic approaches combat cancer.

Language: Английский

Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: May 19, 2025

Background Patients with obesity-associated Hashimoto’s thyroiditis (HT) have been prevalent in clinical practice. Obesity is a risk factor for HT as it promotes pro-inflammatory processes and influences the balance of immune cell subsets. Traditional Chinese medicine (TCM) characterized by its multi-component multi-target approach shows potential treating HT. Specifically, TCM can reduce thyroid antibody levels alleviate symptoms without impairing function. Moreover, offers significant benefits regulating lipid metabolism decreasing systemic inflammation. Methods Targets five high-frequency herbs ( Hedysarum multijugum Maxim, Radix Bupleuri, Prunella vulgaris , Fritillaria thunbergii Bulbus, Angelicae sinensis Radix) were obtained from TCMSP Swiss Target Prediction databases. associated collected GeneCards, OMIM, DisGeNET Subsequently, we employed KEGG signaling pathway enrichment GO biological process analyses to investigate mechanisms which active ingredients these treat Then, STRING database networks Cytoscape software used construct protein-protein interaction network screen key targets. Finally, molecular docking was performed predict binding interactions between Results Efferocytosis emerged mechanism context Quercetin identified primary ingredient responsible efferocytosis, bound well efferocytosis-related Conclusion This study’s finding that prescribed may through efferocytosis. provides new evidence support use

Language: Английский

Efferocytosis in dendritic cells: an overlooked immunoregulatory process

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 21, 2024

Efferocytosis, the process of engulfing and removing apoptotic cells, plays an essential role in preserving tissue health averting undue inflammation. While macrophages are primarily known for this task, dendritic cells (DCs) also play a significant role. This review delves into unique contributions various DC subsets to efferocytosis, highlighting distinctions how DCs recognize handle cells. It further explores efferocytosis influences maturation, thereby affecting immune tolerance. underscores pivotal orchestrating responses sustaining equilibrium, providing new insights their function regulation.

Language: Английский