Genetically predicted leucine level mediates association between CD4/CD8br T lymphocytes and insomnia DOI Creative Commons
Sumei Luo, Jianyin Yin, Ke Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Background Immune and metabolic factors play an important role in the onset development of insomnia. This study aimed to investigate causal relationship between insomnia immune cells metabolites. Methods Data for 731 cell phenotypes, 1,400 metabolites, this were obtained from GWAS open-access database. Two-way Mendelian randomization was used (1) detect insomnia, (2) identify potential mediating Results analysis identified eight phenotypes with a two protective namely CD8br %T CD80 on CD62L + myeloid dendritic cells. The other six risk i.e., CD4/CD8br, CD16-CD56 NKT, CCR2 cells, CD40 monocytes, CD38 CD3-CD19-, CD25 CD45RA CD4 not Treg. Further revealed 11 metabolites that causally related Five 3-hydroxy-3-methylglutarate, cholate, dodecanedioate, N-formylmethionine, x-26054. Six 3-amino-2-piperidone, 6-oxopiperdine-2-carboxylate, caffeine theophylline ratio, leucine, maltose, x-24736. In addition, our showed leucine mediated association CD4/CD8br Conclusions From genetic information, we confirmed eleven metabolite levels. Notably, found leucine-mediated providing evidence supporting plasma serving as mediators.

Language: Английский

Depression and Eye Disease—A Narrative Review of Common Underlying Pathophysiological Mechanisms and their Potential Applications DOI Open Access
Wymann Shao Wen Tang,

Nicole Xer Min Lau,

Muthuramalingam Naveen Krishnan

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(11), P. 3081 - 3081

Published: May 24, 2024

Background: Depression has been shown to be associated with eye diseases, including dry disease (DED), cataracts, glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy (DR). This narrative review explores potential pathophysiological connections between depression disease, as well its correlations ocular parameters. Methods: A literature search was conducted in August 2022 PUBMED, EMBASE, PsycINFO. Published articles related the subject were consolidated classified according respective diseases mechanisms. Results: The reviewed suggests that common states like inflammation neurodegeneration may contribute both certain while somatic symptoms altered physiology, such disruptions circadian rhythm due can also influence patients' mood states. Grounded shared embryological, anatomical, physiological features brain, is correlated changes observed non-invasive ophthalmological imaging modalities, retinal nerve fibre layer microvasculature. Conclusions: There substantial evidence of a close association diseases. Understanding underlying concepts inform further research on treatment options monitoring based

Language: Английский

Citations

6
Genetically Predicted Leucine Level Mediates Association Between CD4/CD8br T Lymphocytes and Insomnia DOI Creative Commons
Sumei Luo, Jianyin Yin, Jie Zhang

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: Jan. 22, 2025

Immune and metabolic factors play an important role in the onset development of insomnia. This study aimed to investigate causal relationship between insomnia immune cells metabolites. Data for 731 cell phenotypes, 1400 metabolites, this were obtained from GWAS open-access database. Two-way Mendelian randomization was used (1) detect (2) identify potential mediating analysis identified eight phenotypes with a insomnia, two protective namely CD8br %T CD80 on CD62L + myeloid dendritic cells. The other six risk i.e., CD4/CD8br, CD16-CD56 NKT, CCR2 cells, CD40 monocytes, CD38 CD3-CD19-, CD25 CD45RA CD4 not Treg. Further revealed 11 metabolites that causally related Five 3-hydroxy-3-methylglutarate, cholate, dodecanedioate, N-formylmethionine, x-26054. Six 3-amino-2-piperidone, 6-oxopiperdine-2-carboxylate, caffeine theophylline ratio, leucine, maltose, x-24736. In addition, our showed leucine mediated association CD4/CD8br From genetic information, we confirmed eleven metabolite levels. Notably, found leucine-mediated providing evidence supporting plasma serving as mediators.

Language: Английский

Citations

0
Genome-wide association study of dry eye disease reveals shared heritability with systemic comorbidities DOI Creative Commons
Bryan R. Gorman,

Jaxon J. Huang,

Peter B. Barr

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Dry eye disease (DED) affects up to 25% of the adult population, with chronic symptoms pain and dryness often negatively impacting quality life. The genetic architecture DED is largely unknown. Here, we develop validate an algorithm for in Million Veteran Program using a combination diagnosis codes prescription records, resulting 132,657 cases 352,201 controls. In multi-ancestry genome-wide association study, identify ten significant loci nine susceptibility regions consistent effects across ancestries, including linked synapse maintenance ( EPHA5 , GRIA1 SYNGAP1 ) autoimmunity BLK ). Phenome-wide scans pleiotropy indicate substantial correlations comorbidities, fibromyalgia, post-traumatic stress disorder, Sjögren's disease. Finally, applying genomic structural equation modeling, derive latent factor underlying other traits which accounts 51% variance DED.

Language: Английский

Citations

0
Tear Film Conditions and Depression Symptoms in Persons with Obesity DOI Creative Commons
Anabel Socorro Sánchez Sánchez, MaGuadalupe Leon‐Verdin, S. Chávez-Cerda

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(16), P. 1768 - 1768

Published: Aug. 14, 2024

Most persons with obesity who have undergone gastric bypass surgery present depressive symptoms. Depression and anxiety been associated tear film disorders. This study aimed to investigate whether there is a correlation between conditions depression symptoms in patients subjected bariatric surgery. The participants completed Patient Health Questionnaire detect break-up time Schirmer test were subsequently applied; the measurements performed three times, average was recorded. results revealed that score PH-9 negatively correlated, but this not case for test. may correlate lower production from principal gland, they same effect on meibomian gland adults undergoing In addition routine control, should be periodically evaluated by an ophthalmologist and/or psychologist aware of potential comorbidities. Furthermore, observed association deficiencies highlights importance further investigations gain better understanding these mechanisms.

Language: Английский

Citations

0
Genetically predicted leucine level mediates association between CD4/CD8br T lymphocytes and insomnia DOI Creative Commons
Sumei Luo, Jianyin Yin, Ke Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Abstract Background Immune and metabolic factors play an important role in the onset development of insomnia. This study aimed to investigate causal relationship between insomnia immune cells metabolites. Methods Data for 731 cell phenotypes, 1,400 metabolites, this were obtained from GWAS open-access database. Two-way Mendelian randomization was used (1) detect insomnia, (2) identify potential mediating Results analysis identified eight phenotypes with a two protective namely CD8br %T CD80 on CD62L + myeloid dendritic cells. The other six risk i.e., CD4/CD8br, CD16-CD56 NKT, CCR2 cells, CD40 monocytes, CD38 CD3-CD19-, CD25 CD45RA CD4 not Treg. Further revealed 11 metabolites that causally related Five 3-hydroxy-3-methylglutarate, cholate, dodecanedioate, N-formylmethionine, x-26054. Six 3-amino-2-piperidone, 6-oxopiperdine-2-carboxylate, caffeine theophylline ratio, leucine, maltose, x-24736. In addition, our showed leucine mediated association CD4/CD8br Conclusions From genetic information, we confirmed eleven metabolite levels. Notably, found leucine-mediated providing evidence supporting plasma serving as mediators.

Language: Английский

Citations

0