PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna, Adina Boulos, Melany Abreu

et al.

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

Legacy and alternative per- and polyfluoroalkyl substances spatiotemporal distribution in China: human exposure, environmental media, and risk assessment DOI
Jing Li,

Wenjing Duan,

Ziwen An

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135795 - 135795

Published: Sept. 12, 2024

Language: Английский

Citations

11
A machine learning-based model for predicting paroxysmal and persistent atrial fibrillation based on EHR DOI Creative Commons
Yuqi Zhang, Sijin Li, Peibiao Mai

et al.

BMC Medical Informatics and Decision Making, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 3, 2025

Language: Английский

Citations

1
Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics DOI Creative Commons
Yán Wāng, Yang Jiang

Environment International, Journal Year: 2024, Volume and Issue: 192, P. 109012 - 109012

Published: Sept. 17, 2024

Language: Английский

Citations

6
Per- and polyfluoroalkyl substances in Chinese commercially available red swamp crayfish (Procambarus clarkii): Implications for human exposure and health risk assessment DOI
Junye Bian, Jiayi Xu, Zhihui Guo

et al.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 356, P. 124369 - 124369

Published: June 12, 2024

Language: Английский

Citations

4
PFAS Exposure and Kidney Health with Gut Microbiota, Blood Metabolites, and Multi-Organ Implications Across Medical Specialties DOI
Nicholas A Kerna, Adina Boulos, Melany Abreu

et al.

European journal of ecology, biology and agriculture., Journal Year: 2025, Volume and Issue: 2(2), P. 30 - 46

Published: March 1, 2025

PFAS (per- and polyfluoroalkyl substances) exposure has been linked to kidney damage through mechanisms involving gut microbiota dysbiosis alterations in blood metabolites. These disruptions trigger renal inflammation, oxidative stress, metabolic dysregulation, impairing function. significantly alters microbial communities, impacting metabolites like short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide (TMAO). imbalances contribute chronic inflammation fibrosis the gut-kidney axis. Additionally, disrupts related energy metabolism, mitochondrial function, lipid oxidation, amino acid metabolism. Biomarkers such as uric acid, creatinine, homocysteine indicate nephrotoxic stress. This paper explores potential by which impact health interactions with It also highlights its effects role affecting multiple body systems that may involve various medical specialists, internists, gastroenterologists, cardiologists, obstetricians, gynecologists, psychiatrists.

Language: Английский

Citations

0