Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Dec. 27, 2024

Abstract Green tea has garnered increasing attention across age groups due to its numerous health benefits, largely attributed Epigallocatechin 3-gallate (EGCG), key polyphenol. EGCG exhibits a wide spectrum of biological activities, including antioxidant, anti-inflammatory, antibacterial, anticancer, and neuroprotective properties, as well benefits for cardiovascular oral health. This review provides comprehensive overview recent findings on the therapeutic potential in various human diseases. Neuroprotective effects include safeguarding neurons from damage enhancing cognitive function, primarily through antioxidant capacity reduce reactive oxygen species (ROS) generated during physiological stress. Additionally, modulates signaling pathways such JAK/STAT, Delta-Notch, TNF, all which play critical roles neuronal survival, growth, function. Furthermore, is involved regulating apoptosis cell cycle progression, making it promising candidate treatment metabolic diseases, cancer diabetes. Despite potential, further clinical trials are essential validate efficacy safety optimize delivery target tissues. While many reviews have addressed anticancer properties EGCG, this focuses molecular mechanisms by used specific particularly cancer, neurodegenerative It serves valuable resource researchers, clinicians, healthcare professionals, revealing managing disorders, diseases highlighting broader values.

Language: Английский

Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.

Language: Английский

Isolation, characterization, and activity of the polysaccharides in Bulbophyllum kwangtumgense Schltr

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 137382 - 137382

Published: Nov. 1, 2024

Language: Английский