Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 264 - 264
Published: Feb. 25, 2025
Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays crucial role in cancer biology, including tumor progression, metastasis, therapeutic resistance. Oxidative stress, similarly, key to maintaining balance oxidants antioxidants, with its disruption leading molecular damage. The interplay between autophagy oxidative particularly significant, as reactive oxygen species (ROS) act both inducers by-products of autophagy. While can function suppressor early stages, it often shifts pro-tumorigenic advanced disease, aiding cell survival under adverse conditions such hypoxia nutrient deprivation. This dual mediated several signaling pathways, PI3K/AKT/mTOR, AMPK, HIF-1α, which coordinate the autophagic activity ROS production. In this review, we explore mechanisms interact across different hematological malignancies. We discuss how triggers autophagy, creating feedback loop promotes survival, dysregulation leads increased accumulation, exacerbating tumorigenesis. also examine implications targeting autophagy-oxidative axis cancer. Current strategies involve modulating through specific inhibitors, enhancing levels pro-oxidant compounds, combining these approaches conventional therapies overcome drug Understanding complex relationship provides critical insights into novel aimed at improving treatment outcomes.
Language: Английский
Citations
1
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(5), P. 189171 - 189171
Published: Aug. 9, 2024
Language: Английский
Citations
6
ACS Omega, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: July 25, 2024
The average lifespan of humans has been increasing, resulting in a rapidly rising percentage older individuals and high morbidity aging-associated diseases, especially cardiovascular diseases (CVDs). Diverse intracellular extracellular factors that interrupt homeostatic functions the endoplasmic reticulum (ER) induce ER stress. Cells employ dynamic signaling pathway unfolded protein response (UPR) to buffer Recent studies have demonstrated stress triggers various cellular processes associated with aging many including CVDs. Autophagy is conserved process involving lysosomal degradation recycling cytoplasmic components, proteins, organelles, pathogens invade cytoplasm. vital for combating adverse influence on heart. present report summarizes recent mechanism autophagy their overlap CVD pathogenesis context aging. It also discusses possible therapeutic interventions targeting might delay prevent or treat
Language: Английский
Citations
3
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 16, 2024
Language: Английский
Citations
1
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Aug. 30, 2024
Circular RNAs (circRNAs) lack the 5'-end methylated guanine cap structure and 3' polyadenylate tail structure, classifying it as a non-coding RNA. With extensive investigation of circRNA, its role in regulating cell death has garnered significant attention recent years, establishing recognized participant cancer's biological processes. Autophagy, an essential pathway programmed (PCD), involves formation autophagosomes using lysosomes to degrade cellular contents under regulation various autophagy-related (ATG) genes. Numerous studies have demonstrated that circRNA can modulate activity cancer cells by influencing autophagy pathway, exhibiting dualistic suppressing or promoting carcinogenesis. In this review, we comprehensively analyze how impacts progression gastrointestinal (GIC). Additionally, discuss drug resistance phenomena associated with GIC. This review offers valuable insights into exploring potential targets for prognosis treatment strategies related
Language: Английский
Citations
1
Journal of Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 74(4)
Published: Nov. 8, 2024
Language: Английский
Citations
1
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 855 - 879
Published: Dec. 7, 2024
Language: Английский
Citations
1
Genes to Cells, Journal Year: 2024, Volume and Issue: 30(1)
Published: Dec. 18, 2024
Aggregation of alpha-synuclein (α-Syn) is implicated in the pathogenesis several neurodegenerative disorders, such as Parkinson's disease and Dementia with Lewy bodies, collectively termed synucleinopathies. Thus, tremendous efforts are being made to develop strategies prevent or inhibit α-Syn aggregation. Here, we genetically engineered fission yeast express human C-terminally fused green fluorescent protein (GFP) at low high levels. was localized cell tips septa low-level expression. At high-level expression, observed form cytoplasmic aggregates. Notably, rapamycin, a natural product that allosterically inhibits mammalian target rapamycin (mTOR) by forming complex FKBP12, Torin1, synthetic mTOR inhibitor blocks ATP binding mTOR, markedly reduced number cells harboring These inhibitors abrogate aggregation without affecting expression Rapamycin, but not failed reduce deletion fkh1
Language: Английский
Citations
1
Methods in molecular biology, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0