Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload DOI Creative Commons
Wen‐Rui Hao, Chun‐Han Cheng, Huan‐Yuan Chen

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2847 - 2847

Published: Dec. 14, 2024

Background/Objectives: Fucoidan, a sulfated polysaccharide derived from marine algae, is known for its antioxidant and immunomodulatory properties. Galectin-3 (Gal-3), protein associated with cardiovascular fibrosis, has been identified as potential therapeutic target in cardiac remodeling. This study aimed to evaluate whether fucoidan could inhibit Gal-3 activity mitigate remodeling mouse model of pressure overload-induced hypertrophy. Methods: To test this hypothesis, we used transverse aortic constriction (TAC) surgery induce overload normotensive mice, replicating the pathological features Mice were treated at dose 1.5 or 7.5 mg/kg/day. In vivo assessments function, inflammation, expression performed. Results: Pressure led significant upregulation serum levels, increased collagen deposition, elevated markers fibrosis inflammation. mice fucoidan, these effects significantly attenuated. Fucoidan treatment prevented Gal-3, reduced decreased inflammatory cell infiltration, suggesting an inhibition both Conclusions: effectively mitigated adverse model, including expression, These findings suggest that holds promise agent preventing delaying complications, such Further research needed explore underlying mechanisms clinical applicability disease.

Language: Английский

Gradient experiment reveals physiological stress from heavy metal zinc on the economically valuable seaweed Sargassum fusiforme DOI
Yangfu Kuang,

Dongmei Bao,

Xingda Sheng

et al.

Marine Environmental Research, Journal Year: 2025, Volume and Issue: 204, P. 106958 - 106958

Published: Jan. 8, 2025

Language: Английский

Citations

0
Fucoidan Attenuates Cardiac Remodeling by Inhibiting Galectin-3 Secretion, Fibrosis, and Inflammation in a Mouse Model of Pressure Overload DOI Creative Commons
Wen‐Rui Hao, Chun‐Han Cheng, Huan‐Yuan Chen

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2847 - 2847

Published: Dec. 14, 2024

Background/Objectives: Fucoidan, a sulfated polysaccharide derived from marine algae, is known for its antioxidant and immunomodulatory properties. Galectin-3 (Gal-3), protein associated with cardiovascular fibrosis, has been identified as potential therapeutic target in cardiac remodeling. This study aimed to evaluate whether fucoidan could inhibit Gal-3 activity mitigate remodeling mouse model of pressure overload-induced hypertrophy. Methods: To test this hypothesis, we used transverse aortic constriction (TAC) surgery induce overload normotensive mice, replicating the pathological features Mice were treated at dose 1.5 or 7.5 mg/kg/day. In vivo assessments function, inflammation, expression performed. Results: Pressure led significant upregulation serum levels, increased collagen deposition, elevated markers fibrosis inflammation. mice fucoidan, these effects significantly attenuated. Fucoidan treatment prevented Gal-3, reduced decreased inflammatory cell infiltration, suggesting an inhibition both Conclusions: effectively mitigated adverse model, including expression, These findings suggest that holds promise agent preventing delaying complications, such Further research needed explore underlying mechanisms clinical applicability disease.

Language: Английский

Citations

0