Dietary Flavonoid Intake and Anemia Risk in Children and Adolescents: Insights from National Health and Nutrition Examination Survey

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 395 - 395

Published: March 27, 2025

Anemia, a global health concern, significantly impacts children and adolescents, impairing their physical cognitive development. While nutritional deficiencies are primary contributors, oxidative stress has emerged as key factor in anemia pathogenesis. Flavonoids, known for antioxidant properties, may play protective role, but relationship with pediatric populations remains underexplored. Using data from the National Health Nutrition Examination Survey (NHANES) cycles (2007–2008, 2009–2010, 2017–2018), we analyzed 6815 participants aged ≤20 years to investigate association between dietary flavonoid intake risk. Flavonoid was assessed via two 24 h recalls, defined using WHO hemoglobin thresholds. Multivariable logistic regression restricted cubic spline (RCS) models were employed, adjusting sociodemographic, dietary, lifestyle factors. The results showed that lower associated increased High-intake groups of total flavonoids flavan-3-ols linked reduced prevalence compared low-intake groups, odds ratios (ORs) OR = 0.641 (95% CI: 0.439, 0.935) 0.612 0.406, 0.921), respectively. This study highlights potential role flavonoids, particularly flavan-3-ols, reducing risk among underscoring importance flavonoid-rich diets prevention.

Language: Английский

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Flavonoid-Based Nanogels: A Comprehensive Overview

Gels, Journal Year: 2025, Volume and Issue: 11(4), P. 267 - 267

Published: April 4, 2025

The growing field of nanotechnology has recently given much attention to nanogels, which are versatile formulas and have promising biomedical applications. Nanogels or nanohydrogels undergone significant development in various fields industrial research meet increasing demands, such as pharmaceuticals, cosmetics, food, genetic engineering. that contain flavonoids, secondary metabolites found plants, starting become distinctive reveal their unique characteristics. objective the article is provide a comprehensive overview recent articles on flavonoid-based emphasizing general aspects regarding nanogel formulation structural characterization, well advancements made field. In conclusion, this outlines up-to-date developments synthesis, formulation, therapeutic applications important role nanotechnology.

Language: Английский

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Natural Compounds in Cancer Therapy: Revealing the Role of Flavonoids in Renal Cell Carcinoma Treatment

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 620 - 620

Published: April 25, 2025

Renal cell carcinoma (RCC) is the most lethal malignancy of urinary system, with limited treatment options due to drug resistance and adverse effects associated current therapies. This review aims systematically examine therapeutic potential flavonoids, which are natural polyphenolic compounds possessing anti-inflammatory, antioxidant, anticancer properties, in context RCC treatment. We summarize activities 26 classified into six subclasses, explore their mechanisms action, including inhibition tumor proliferation, migration, invasion, as well induction apoptosis, autophagy, ferroptosis. Particular attention paid modulation key signaling pathways such JAK/STAT3, PI3K/Akt/mTOR, miRNA-related axes, miR-21/YAP1 miR-324-3p/GPX4, providing a molecular basis for anti-RCC activity. also address several pharmacological challenges that limit clinical application poor bioavailability, metabolic instability, toxicity. Emerging solutions novel flavonoid derivatives, advanced delivery systems, rational combination therapy strategies discussed. Current evidence, phase II trial flavopiridol RCC, highlights but need further validation. In conclusion, flavonoids offer promising approach improving Future research should focus on optimizing efficacy ensuring safe translation, goal achieving personalized minimally invasive cancer

Language: Английский

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