Physiological Reviews,
Journal Year:
2022,
Volume and Issue:
103(2), P. 1059 - 1093
Published: Oct. 6, 2022
The
pathophysiology
of
chronic
obstructive
pulmonary
disease
(COPD)
and
the
undisputed
role
innate
immune
cells
in
this
condition
have
dominated
field
basic
research
arena
for
many
years.
Recently,
however,
compelling
data
suggesting
that
adaptive
may
also
contribute
to
progressive
nature
lung
destruction
associated
with
COPD
smokers
gained
considerable
attention.
histopathological
changes
lungs
can
be
limited
large
or
small
airways,
but
alveolar
loss
leading
emphysema,
which
occurs
some
individuals,
remains
its
most
significant
irreversible
outcome.
Critically,
question
why
emphysema
progresses
a
subset
former
remained
mystery
recognition
activated
organized
tertiary
T-
B-lymphoid
aggregates
emphysematous
provided
first
clue
play
crucial
pathophysiology.
Based
on
these
findings
from
human
translational
studies,
experimental
animal
models
were
used
determine
mechanisms
through
smoke
exposure
initiates
orchestrates
autoreactive
inflammation
lungs.
These
revealed
T
helper
(Th)1
Th17
subsets
promote
positive
feedback
loop
activates
cells,
confirming
their
pathogenesis.
Results
genetic
studies
immune-based
discoveries
further
strong
evidence
autoimmunity
induction
emphysema.
new
offer
novel
opportunity
explore
underlying
inflammatory
landscape
insights
development
precision-based
treatment
halt
destruction.
Nutrients,
Journal Year:
2019,
Volume and Issue:
11(9), P. 2039 - 2039
Published: Sept. 1, 2019
The
Mediterranean
diet
is
considered
as
the
foremost
dietary
regimen
and
its
adoption
associated
with
prevention
of
degenerative
diseases
an
extended
longevity.
preeminent
features
have
been
agreed
upon
consumption
olive
oil
stands
out
most
peculiar
one.
Indeed,
use
nearly
exclusive
fat
what
mostly
characterizes
area.
Plenty
epidemiological
studies
correlated
that
was
better
overall
health.
extra
virgin
contains
(poly)phenolic
compounds
are
being
actively
investigated
for
their
purported
biological
pharma-nutritional
properties.
On
18
19
May
2018,
several
experts
convened
in
Jaen
(Spain)
to
discuss
recent
research
on
benefits
components.
We
reported
a
summary
meeting
(reviewing
topics
related
oil,
not
limited
health)
concluded
substantial
evidence
accruing
support
widespread
opinion
should,
indeed,
be
choice
when
it
comes
human
health
sustainable
agronomy.
Cell Research,
Journal Year:
2023,
Volume and Issue:
33(2), P. 97 - 115
Published: Jan. 5, 2023
Abstract
Autoimmunity
and
autoinflammation
arise
from
aberrant
immunological
inflammatory
responses
toward
self-components,
contributing
to
various
autoimmune
diseases
autoinflammatory
diseases.
RNA-binding
proteins
(RBPs)
are
essential
for
immune
cell
development
function,
mainly
via
exerting
post-transcriptional
regulation
of
RNA
metabolism
function.
Functional
dysregulation
RBPs
abnormities
in
closely
associated
with
multiple
or
disorders.
Distinct
play
critical
roles
autoreactive
orchestrating
a
complex
regulatory
network
consisting
DNAs,
RNAs
within
cells.
In-depth
characterizations
RBP–RNA
interactomes
during
autoimmunity
will
lead
better
understanding
pathogenesis
facilitate
the
effective
therapeutic
strategies.
In
this
review,
we
summarize
discuss
functions
interactions
controlling
inflammation
their
potential
as
biomarkers
targets.
Oncotarget,
Journal Year:
2017,
Volume and Issue:
8(14), P. 23650 - 23663
Published: Feb. 21, 2017
Despite
increasing
evidence
that
long
non-coding
RNAs
(lncRNAs)
widely
take
part
in
human
diseases,
the
role
of
lncRNAs
systemic
lupus
erythematosus
(SLE)
is
largely
unknown.
In
this
study,
we
performed
a
two-stage
study
to
explore
plasma
levels
five
(GAS5,
linc0949,
linc0597,
HOTAIRM1
and
lnc-DC)
their
potential
as
SLE
biomarkers.
Compared
with
healthy
controls,
GAS5
lnc-DC
were
significantly
decreased
(P
<
0.001
P
=
0.002,
respectively)
while
linc0597
overexpressed
patients
0.001).
When
divided
into
without
nephritis
(LN),
higher
LN
compared
0.018),
but
no
significant
difference
found
between
nephritis;
linc0949
level
showed
all
comparisons.
Further
evaluation
on
biomarkers
GAS5,
may
specifically
identify
SLE,
combination
provided
better
diagnostic
accuracy;
discriminate
from
nephritis.
summary,
could
be
for
SLE.
Cellular and Molecular Immunology,
Journal Year:
2018,
Volume and Issue:
15(7), P. 676 - 684
Published: Jan. 29, 2018
B
cells
have
a
critical
role
in
the
initiation
and
acceleration
of
autoimmune
diseases,
especially
those
mediated
by
autoantibodies.
In
peripheral
lymphoid
system,
mature
are
activated
self
or/and
foreign
antigens
signals
from
helper
T
for
differentiating
into
either
memory
or
antibody-producing
plasma
cells.
Accumulating
evidence
has
shown
that
epigenetic
regulations
modulate
somatic
hypermutation
class
switch
DNA
recombination
during
B-cell
activation
differentiation.
Any
abnormalities
these
complex
regulatory
processes
may
contribute
to
aberrant
antibody
production,
resulting
pathogenesis
such
as
systemic
lupus
erythematosus.
Newly
generated
knowledge
advanced
modern
technologies
next-generation
sequencing,
single-cell
sequencing
methylation
enabled
us
better
understand
biology
its
development.
Thus
this
review
aims
summarize
current
research
progress
modifications
contributing
differentiation,
under
conditions
lupus,
rheumatoid
arthritis
type
1
diabetes.
