Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Sept. 26, 2023
Psoriasis
is
a
complex,
chronic
autoimmune
disorder
predominantly
affecting
the
skin.
Accumulating
evidence
underscores
critical
role
of
localized
cellular
inflammation
in
development
and
persistence
psoriatic
skin
lesions,
involving
cell
types
such
as
keratinocytes,
mesenchymal
cells,
Schwann
cells.
However,
underlying
mechanisms
remain
largely
unexplored.
Long
non-coding
RNAs
(lncRNAs),
known
to
regulate
gene
expression
across
various
processes,
have
been
particularly
implicated
immune
regulation.
We
utilized
our
neural-network
learning
pipeline
integrate
106,675
cells
from
healthy
human
79,887
This
formed
most
extensive
transcriptomic
atlas
date.
The
robustness
reclassified
cell-types,
representing
full-layer
zonation
skin,
was
affirmed
through
learning-based
cross-validation.
then
developed
publicly
available
website
present
this
integrated
dataset.
carried
out
analysis
for
differentially
expressed
lncRNAs,
co-regulated
patterns,
GO-bioprocess
enrichment,
enabling
us
pinpoint
lncRNAs
that
modulate
psoriasis
at
single-cell
level.
Subsequent
experimental
validation
with
lines
primary
confirmed
these
lncRNAs'
functional
inflammation.
Our
study
provides
comprehensive
both
conditions,
unveiling
new
regulatory
mechanism
governs
highlights
therapeutic
potential
disease's
management.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 22, 2023
Endometriosis
is
a
complex
disorder
that
characterized
by
the
abnormal
growth
of
endometrial-like
tissue
outside
uterus.
It
associated
with
chronic
inflammation,
severe
pelvic
pain,
infertility,
and
significantly
reduced
quality
life.
Although
exact
mechanism
endometriosis
remains
unknown,
inflammation
altered
immunity
are
considered
key
factors
in
immunopathogenesis
disorder.
Disturbances
immune
responses
result
clearance
regurgitated
endometrial
cells,
which
elicits
oxidative
stress
progression
inflammation.
Proinflammatory
mediators
could
affect
cells’
recruitment,
fate,
function.
Reciprocally,
activation
cells
can
promote
Aberrant
expression
non-coding
RNA
(ncRNA)
patient
animal
lesions
be
suggestive
their
role
establishment.
The
engagement
these
RNAs
regulating
diverse
biological
processes,
including
inflammatory
inflammasomes,
immunity,
cell
proliferation,
migration,
invasion,
angiogenesis
widespread
far-reaching.
Therefore,
ncRNAs
identified
as
determining
candidate
system.
This
review
aims
addition
to
predict
through
based
on
previous
studies,
it
presents
comprehensive
view
pathogenesis
endometriosis.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(2), P. e41836 - e41836
Published: Jan. 1, 2025
The
immune
response
is
an
intricate
system
that
involves
the
complex
connection
of
cellular
and
molecular
components,
each
with
distinct
functional
specialisations.
It
has
a
capacity
to
adjust
mould
in
accordance
specific
stimuli,
influenced
by
both
genetic
environmental
factors.
presence
diversity,
particularly
across
different
ethnic
racial
groups,
significantly
contributes
impact
incidence
diseases,
disease
susceptibility,
autoimmune
disorders,
cancer
risks
regions
certain
populations.
Environmental
factors,
including
geography
socioeconomic
status,
further
modulate
variety
responses.
These,
turn,
affect
susceptibility
infectious
diseases
development
disorders.
Despite
complexity
relationship,
there
remains
gap
understanding
specificity
indices
races,
reference
ranges
among
populations,
highlighting
need
for
deeper
diversity
personalized
approaches
diagnostics
therapeutics.
This
review
systematically
organizes
these
findings,
goal
emphasizing
potential
targeted
interventions
address
health
disparities
advance
translational
research,
enabling
more
comprehensive
strategy.
approach
promises
significant
advancements
identifying
immunological
conditions,
focusing
on
interventions,
through
Clinical and Experimental Medicine,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: March 7, 2025
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
characterized
by
inflammatory
responses
in
the
joints,
synovial
hyperplasia,
persistent
abnormal
proliferation
of
fibroblast-like
synoviocytes
(FLSs),
and
cartilage
erosion,
leading
to
joint
swelling
destruction.
The
underlying
mechanisms
this
entail
complex
interplay
factors,
with
long
noncoding
RNAs
(lncRNAs)
serving
as
main
contributors.
These
lncRNAs,
which
are
over
200
bp
length,
involved
regulating
responses,
damage,
FLS
growth.
Studies
have
shown
that
lncRNAs
dual
function
progression
RA,
they
can
both
promote
control
reduce
symptoms.
Nevertheless,
our
current
understanding
development
RA
incomplete,
exact
molecular
process
remain
unclear.
This
study
aims
elucidate
exert
their
inhibitory
stimulatory
effects,
well
explore
potential
diagnosing,
predicting
prognosis,
targeting
therapy
for
RA.
