The gut ecosystem and immune tolerance

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103114 - 103114

Published: Sept. 23, 2023

The gastrointestinal tract is home to the largest microbial population in human body. gut microbiota plays significant roles development of immune system and has a substantial impact on maintenance tolerance beginning early life. These microbes interact with dynamic interdependent manner. They generate signals by presenting vast repertoire antigenic determinants metabolites that influence development, maturation immunological function homeostasis. At same time, both innate adaptive systems are involved modulating stable ecosystem between commensal pathogenic microorganisms. Hence, host work together maintain homeostasis synergistically. In susceptible hosts, disruption such harmonious state can greatly affect health lead various auto-inflammatory autoimmune disorders. this review, we discuss our current understanding interactions immunity an emphasis on: a) important players immunity; b) contribution metabolites; c) effect as well alteration microbiome molecular mechanisms driving autoimmunity diseases.

Language: Английский

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The influence and therapeutic effect of microbiota in systemic lupus erythematosus

Microbiological Research, Journal Year: 2024, Volume and Issue: 281, P. 127613 - 127613

Published: Jan. 14, 2024

Language: Английский

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Fecal microbiota transplantation in autoimmune diseases – An extensive paper on a pathogenetic therapy

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(7-8), P. 103541 - 103541

Published: April 7, 2024

Language: Английский

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Exploring the role of gut microbiome in autoimmune diseases: A comprehensive review

Autoimmunity Reviews, Journal Year: 2024, Volume and Issue: 23(12), P. 103654 - 103654

Published: Oct. 9, 2024

Language: Английский

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Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 101977 - 101977

Published: March 25, 2025

Language: Английский

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Exploring Gut Microbiota in Systemic Lupus Erythematosus: Insights and Biomarker Discovery Potential

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: April 11, 2025

Language: Английский

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The influence of the gut microbiota on B cells in autoimmune diseases

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: April 22, 2025

Abstract Mounting evidence shows that gut microbiota communities and the human immune system coexist influence each other, there are a number of reports correlation between specific changes in occurrence autoimmune diseases. B lymphocytes play central role regulation both Here, we summarize microbiota-B cell pathways on diseases how cells regulate microorganisms, which provides mechanistic insights with relevance for identification potential therapeutic targets related fields.

Language: Английский

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Translational strategies for oral delivery of faecal microbiota transplantation

Gut, Journal Year: 2025, Volume and Issue: unknown, P. gutjnl - 335077

Published: April 29, 2025

Faecal microbiota transplantation (FMT) has emerged as a transformative therapy for Clostridioides difficile infections and shows promise various GI systemic diseases. However, the poor patient acceptability accessibility of ‘conventional’ FMT, typically administered via colonoscopies or enemas, hinders its widespread clinical adoption, particularly chronic conditions. Oral administration FMT (OralFMT) overcomes these limitations, yet faces distinct challenges, including significant capsule burden, palatability concerns microbial viability during gastric transit. This review provides comprehensive analysis emerging strategies that aim to advance OralFMT by: (1) refining processing technologies (eg, lyophilisation) enable manufacturing low-volume formulations reducing burden (2) developing delivery improve organoleptic safeguard targeted colonic release. These advancements present opportunities expand therapeutic scope, beyond C. infections, towards conditions requiring frequent dosing regimens. While this primarily focuses on optimising delivery, it is important contextualise within broader shift defined consortia. Live biotherapeutic products (LBPs) offer an alternative approach, interplay between LBPs in practice remains unresolved. We postulate continued innovation multidisciplinary approach can further increase efficacy scalability by enabling disease site targeting, co-delivery compounds overcoming colonisation resistance. Realising goals positions cornerstone personalised care across range diseases rooted microbiome health.

Language: Английский

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Fecal microbiota transplantation in the treatment of systemic lupus erythematosus: What we learnt from the explorative clinical trial

Journal of Autoimmunity, Journal Year: 2023, Volume and Issue: 141, P. 103058 - 103058

Published: May 11, 2023

Language: Английский

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Single-cell RNA sequencing in autoimmune diseases: New insights and challenges

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108807 - 108807

Published: Jan. 1, 2025

Language: Английский

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