Circadian Clock Dysregulation and Prostate Cancer: A Molecular and Clinical Overview

Clinical Medicine Insights Oncology, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 1, 2023

Circadian clock dysregulation has been implicated in various types of cancer and represents an area growing research. However, the role circadian prostate relatively unexplored. This literature review will highlight potential by examining molecular, epidemiologic, clinical data. The influence melatonin, light, night shift work, chronotherapy, androgen independence are discussed as they relate to existing on their cancer.

Language: Английский

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The role of circadian clock genes in colorectal carcinoma: Novel insights into regulatory mechanism and implications in clinical therapy

Life Sciences, Journal Year: 2023, Volume and Issue: 333, P. 122145 - 122145

Published: Oct. 4, 2023

Language: Английский

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Cancer Stem Cells and Their Vesicles, Together with Other Stem and Non-Stem Cells, Govern Critical Cancer Processes: Perspectives for Medical Development

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 625 - 625

Published: Jan. 6, 2022

Stem cells, identified several decades ago, started to attract interest at the end of nineties when families mesenchymal stem cells (MSCs), concentrated in stroma most organs, were found participate therapy many diseases. In cancer, however, high importance are specific another family, cancer (CSCs). This comprehensive review is focused on role and mechanisms CSCs their extracellular vesicles (EVs), which composed both exosomes ectosomes. Compared non-stem (normal) exist small populations that preferentially distributed niches, such as minor tissue sites corresponding non-cancer tissues. At niches marginal other masses, exhibits peculiar properties typical tumor microenvironment (TME) cancers. The matrix (ECM) includes components different from EVs, addition effects analogous those MSCs/EVs, processes key importance, cancer: generation distinct cell subtypes, proliferation, differentiation, progression, formation metastases, immune resistance, relapse. Many these, other, require CSC cooperation with surrounding especially MSCs. Filtered macrophages fibroblasts, contribute collaborative transition/integration processes. Therapy developments mentioned ongoing preclinical initiatives. preliminary state clinical medicine presented terms industrial development future treatments. latter will be administered patients together known drugs, aim eradicating growth metastases.

Language: Английский

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Chronomodulated Administration of Chemotherapy in Advanced Colorectal Cancer: A Systematic Review and Meta-Analysis

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: March 22, 2023

In this systematic review, the efficacy and safety of chronomodulated chemotherapy, defined as delivery chemotherapy timed according to human circadian rhythm, were assessed compared continuous infusion for patients with advanced colorectal cancer. Electronic English-language studies published until October 2020 searched. Randomised controlled trials (RCTs) comparing non-chronomodulated (conventional) management cancer included. The main outcomes objective response rate (ORR) system-specific overall toxicity related chemotherapy. databases including Ovid Medline, Embase, Cochrane Central Register Controlled Trials Database Systematic Review total, seven RCTs 1,137 analysed. Males represented 684 (60%) study population. median age was 60.5 (range = 47.2-64) years. There no significant difference between conventional in ORR (risk ratio (RR) 1.15; 95% confidence interval (CI) 0.87-1.53). Similarly, there gastrointestinal under random effect model (RR 1.02; CI 0.68-1.51). No found regarding neurological skin toxicities 0.64, 0.32-1.270 RR 2.11, 0.33-13.32, respectively). However, who received had less haematological 0.36, 0.27-0.48). conclusion, or haematologic used Chronomodulated can be considered at high risk toxicities.

Language: Английский

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Target-triggered CRISPR–Cas13a autocatalysis-driven amplification strategy for one-step detection of circadian clock gene

Sensors & Diagnostics, Journal Year: 2023, Volume and Issue: 2(3), P. 632 - 639

Published: Jan. 1, 2023

A CRISPR–Cas13a-powered autocatalytic cleavage circuit (CRISPR-ACC) for ultrasensitive and specific detection of a circadian clock gene was developed.

Language: Английский

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