Frontiers in Ophthalmology,
Journal Year:
2024,
Volume and Issue:
4
Published: Dec. 2, 2024
Accommodation
is
the
process
of
changing
ocular
lens'
refractive
power
and
focal
distance.
This
involves
application
biomechanical
forces
on
lens
by
surrounding
musculature.
Previous
studies
have
demonstrated
that
epithelium
demonstrates
mechanotransduction
tension
influences
its
chemical
activity.
It
not
yet
known
how
these
affect
structure
permeability
lens.
study
aimed
to
identify
influence
molecular
transport
dyes
through
Cells,
Journal Year:
2023,
Volume and Issue:
12(12), P. 1580 - 1580
Published: June 7, 2023
BFSP1
(beaded
filament
structural
protein
1)
is
a
plasma
membrane,
Aquaporin
0
(AQP0/MIP)-associated
intermediate
expressed
in
the
eye
lens.
myristoylated,
post-translation
modification
that
requires
caspase
cleavage
at
D433.
Bioinformatic
analyses
suggested
sequences
434-452
were
α-helical
and
amphipathic.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(35)
Published: Oct. 28, 2023
Positioned
within
the
eye,
lens
supports
vision
by
transmitting
and
focusing
light
onto
retina.
As
an
adaptive
glassy
material,
is
constituted
primarily
densely-packed,
polydisperse
crystallin
proteins
that
organize
to
resist
aggregation
crystallization
at
high
volume
fractions,
yet
details
of
how
crystallins
coordinate
with
one
another
template
maintain
this
transparent
microstructure
remain
unclear.
The
role
individual
subtypes
(α,
β,
γ)
paired
subtype
compositions,
including
they
experience
crowding-induced
turbidity
in
solution,
explored
using
combinations
spectrophotometry,
hard-sphere
simulations,
surface
pressure
measurements.
After
assaying
combinations,
β-crystallins
emerged
as
a
principal
component
all
mixtures
enabled
dense
fluid-like
packing
short-range
order
necessary
for
transparency.
These
findings
helped
inform
design
lens-like
hydrogel
systems,
which
are
used
monitor
manipulate
loss
transparency
under
different
crowding
conditions.
When
taken
together,
illustrate
characterization
materials
made
from
can
be
better
understand
mechanisms
regulating
Advances in Redox Research,
Journal Year:
2022,
Volume and Issue:
7, P. 100057 - 100057
Published: Dec. 14, 2022
Ionising
radiation
(IR)
is
a
cause
of
lipid
peroxidation,
and
epidemiological
data
have
revealed
correlation
between
exposure
to
IR
the
development
eye
lens
cataracts.
Cataracts
remain
leading
blindness
around
world.
The
plasma
membranes
fibre
cells
are
one
most
cholesterolrich
in
human
body,
forming
rafts
contributing
biophysical
properties
membrane.
Liquid
chromatography
followed
by
mass
spectrometry
was
used
analyse
bovine
membrane
fractions
after
5
50
Gy
lenses
taken
from
wholebody
2
Gy-irradiated
mice.
Although
cholesterol
levels
do
not
change
significantly,
dose-dependant
formation
oxysterols
7β-hydroxycholesterol,
7-ketocholesterol
5,
6-epoxycholesterol
nucleus
extracts
observed.
Whole-body
X-ray
(2
Gy)
12-week
old
mice
resulted
an
increase
7β-hydroxycholesterol
their
lenses.
Their
regressed
over
24
h
living
cortex
exposure.
This
study
also
demonstrated
that
IR-induced
fold
greater
mouse
than
nucleus.
Further
work
required
elucidate
mechanistic
link(s)
cataract,
but
these
evidence
for
first
time
results
oxysterol
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 13, 2024
ABSTRACT
Summary
Statement
This
study
illustrates
a
vital
role
for
ankyrin-B
in
lens
architecture,
growth
and
function
through
its
involvement
membrane
protein
spectrin-actin
cytoskeletal
organization
stability
The
transparent
ocular
is
essential
vision
by
focusing
light
onto
the
retina.
Despite
recognizing
importance
of
unique
cellular
architecture
mechanical
properties,
molecular
mechanisms
governing
these
attributes
remain
elusive.
aims
to
elucidate
(AnkB),
scaffolding
protein,
cytoarchitecture,
using
conditional
knockout
(cKO)
mouse
model.
AnkB
cKO
has
no
defects
morphogenesis,
but
exhibited
changes
that
supported
global
maintenance
clarity,
size,
stiffness.
Notably,
absence
led
nuclear
cataract
formation,
evident
from
P16.
fibers
exhibit
progressive
disruption
cytoskeleton,
channel
proteins,
cell-cell
adhesion,
shape
change,
loss
degradation
several
proteins
(e.g.,
NrCAM.
N-cadherin
aquaporin-0)
along
with
disorganized
plasma
impaired
ball-and-socket
interdigitations.
Furthermore,
decreased
Collectively,
results
illustrate
organization.
Frontiers in Ophthalmology,
Journal Year:
2024,
Volume and Issue:
4
Published: Dec. 2, 2024
Accommodation
is
the
process
of
changing
ocular
lens'
refractive
power
and
focal
distance.
This
involves
application
biomechanical
forces
on
lens
by
surrounding
musculature.
Previous
studies
have
demonstrated
that
epithelium
demonstrates
mechanotransduction
tension
influences
its
chemical
activity.
It
not
yet
known
how
these
affect
structure
permeability
lens.
study
aimed
to
identify
influence
molecular
transport
dyes
through
