A glimpse into the world of microRNAs and their putative roles in hard ticks DOI Creative Commons

Brenda Leal-Galvan,

Deepak Kumar, Shahid Karim

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 23, 2024

Ticks are important blood feeding ectoparasites that transmit pathogens to wildlife, domestic animals, and humans. Hard ticks can feed for several days weeks, nevertheless they often go undetected. This phenomenon be explained by a tick’s ability release analgesics, immunosuppressives, anticoagulants, vasodilators within their saliva. Several studies have identified extracellular vesicles (EVs) as carriers of some these effector molecules. Further, EVs, contents, enhance pathogen transmission, modulate immune responses, delay wound healing. EVs double lipid-membrane transport intracellular cargo, including microRNAs (miRNAs) recipient cells. miRNAs involved in regulating gene expression post-transcriptionally. Interestingly, tick-derived been shown transmission affect vital biological processes such oviposition, digestion, molting. found tick salivary EVs. review focuses on current knowledge miRNA loading into homologies reported ticks. We also describe findings profiles, packed Although no functional done investigate the role EV-derived feeding, we discuss characterization biology transmission. Lastly, propose possible uses develop management tools control prevent The identification conserved tick-specific targeting molecular immunological pathways host could lead discovery new therapeutics treatment tick-borne non-tick-borne human diseases.

Language: Английский

A glimpse into the world of microRNAs and their putative roles in hard ticks DOI Creative Commons

Brenda Leal-Galvan,

Deepak Kumar, Shahid Karim

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Sept. 23, 2024

Ticks are important blood feeding ectoparasites that transmit pathogens to wildlife, domestic animals, and humans. Hard ticks can feed for several days weeks, nevertheless they often go undetected. This phenomenon be explained by a tick’s ability release analgesics, immunosuppressives, anticoagulants, vasodilators within their saliva. Several studies have identified extracellular vesicles (EVs) as carriers of some these effector molecules. Further, EVs, contents, enhance pathogen transmission, modulate immune responses, delay wound healing. EVs double lipid-membrane transport intracellular cargo, including microRNAs (miRNAs) recipient cells. miRNAs involved in regulating gene expression post-transcriptionally. Interestingly, tick-derived been shown transmission affect vital biological processes such oviposition, digestion, molting. found tick salivary EVs. review focuses on current knowledge miRNA loading into homologies reported ticks. We also describe findings profiles, packed Although no functional done investigate the role EV-derived feeding, we discuss characterization biology transmission. Lastly, propose possible uses develop management tools control prevent The identification conserved tick-specific targeting molecular immunological pathways host could lead discovery new therapeutics treatment tick-borne non-tick-borne human diseases.

Language: Английский

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