Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 47(1), P. 4 - 4
Published: Dec. 25, 2024
Amino acid metabolism in breast cancer cells is unique for each molecular biological subtype of cancer. In this review, the features cell are considered terms changes amino composition due to activity transmembrane transporters. addition main signaling pathway PI3K/Akt/mTOR, oncogene c-Myc, HIF, p53, GATA2, NF-kB and MAT2A have a direct effect on cells, their growth proliferation, as well maintenance homeostatic equilibrium. A distinctive feature luminal subtypes from TNBC ability perform gluconeogenesis. Breast cancers with positive expression HER2 receptor, contrast subtype, active synthesis consumption fatty acids. It interesting note that transporters exhibit depending pH level inside cell. most aggressive forms or gradual progression disease, will also change, which directly affect Using lines presented we can trace characteristic inherent develop optimal therapeutic targets.
Language: Английский